Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chen Huang, Jiayi Li, Ruiyan Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 3, 2025

Pyroptosis is a distinct form of programmed cell death characterized by the rupture membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects tumor microenvironment antitumor immunity releasing damage-associated molecular patterns (DAMPs) pro-inflammatory mediators, thereby establishing it as pivotal target in cancer immunotherapy. This review thoroughly explores mechanisms underlying pyroptosis, with particular focus on inflammasome activation gasdermin family proteins (GSDMs). It examines role pyroptotic reshaping immune (TIME) involving both cells, discusses recent advancements targeting pathways through therapeutic strategies such small molecule modulators, engineered nanocarriers, combinatory treatments checkpoint inhibitors. We also advances future directions to enhance immunotherapy inhibitors, adoptive therapy, vaccines. study suggested offers promising avenue amplify responses surmount resistance existing immunotherapies, potentially leading more efficacious treatments.

Language: Английский

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers DOI Creative Commons
Simona Premcheska, André G. Skirtach, Anna M. Kaczmarek

et al.

Advanced NanoBiomed Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Lanthanide‐based luminescence nanothermometry has demonstrated unprecedented advantages in the development of nanotheranostic platforms for potential medical applications, yet despite exponential research progress and great enthusiasm across various related disciplines, a swift bench‐to‐bedside translation seems to be still out reach. This is predominantly fundamental issues at preclinical stage, such as complex nanomaterials design, incomplete optimization, fragmented characterization, insufficient validation nanothermometer performance physiological environments. The main impediments currently are important biophysicochemical that must addressed comprehensively, first foremost available vitro systems, before going on vivo investigations. review outlines critical perspective, well route suggestions underexplored aspects address significantly minimize existing translational gap.

Language: Английский

Citations

0
Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives DOI Creative Commons
Chen Huang, Jiayi Li, Ruiyan Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 3, 2025

Pyroptosis is a distinct form of programmed cell death characterized by the rupture membrane and robust inflammatory responses. Increasing evidence suggests that pyroptosis significantly affects tumor microenvironment antitumor immunity releasing damage-associated molecular patterns (DAMPs) pro-inflammatory mediators, thereby establishing it as pivotal target in cancer immunotherapy. This review thoroughly explores mechanisms underlying pyroptosis, with particular focus on inflammasome activation gasdermin family proteins (GSDMs). It examines role pyroptotic reshaping immune (TIME) involving both cells, discusses recent advancements targeting pathways through therapeutic strategies such small molecule modulators, engineered nanocarriers, combinatory treatments checkpoint inhibitors. We also advances future directions to enhance immunotherapy inhibitors, adoptive therapy, vaccines. study suggested offers promising avenue amplify responses surmount resistance existing immunotherapies, potentially leading more efficacious treatments.

Language: Английский

Citations

0