Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods DOI

Nusrath Yasmeen,

Anis Ahmad Chaudhary,

Salauddin Khan

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: 29(1), P. 215 - 239

Published: April 28, 2024

Language: Английский

Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations DOI
Haytham O. Tawfik, Mai H. A. Mousa, Mohamed Y. Zaky

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 149, P. 107483 - 107483

Published: May 21, 2024

Language: Английский

Citations

7
Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy DOI

Norhan A. Abdelrahman,

Ahmed A. Al‐Karmalawy, Maiy Y. Jaballah

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(3), P. 981 - 997

Published: Jan. 1, 2024

Novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Language: Английский

Citations

6
Synthesis of some new nanoparticles mixed metal complexes of febuxostat in presence of 2,2′-bipyridine: Characterization, DFT, antioxidant and molecular docking activities DOI
Leila M. Abbass,

Sadeek Atia Sadeek,

Maged A. Aziz

et al.

Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 386, P. 122460 - 122460

Published: June 29, 2023

Language: Английский

Citations

15
Pyrazole, Pyrazoline, and Fused Pyrazole Derivatives: New Horizons in EGFR‐Targeted Anticancer Agents DOI
Ketan R Hosamani, K. Hemalatha, Rohit Pal

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(11)

Published: July 26, 2024

Pyrazole and its derivatives remain popular heterocycles in drug research, design, development. Several drugs include the pyrazole scaffold, such as ramifenazone, ibipinabant, antipyrine, axitinib, etc. They have been extensively studied by scientific community are said to a wide range of biological activity, especially anticancer agents targeting EGFR. Overexpression EGFR signalling promotes tumor growth inhibiting apoptosis. dysfunction has described multiple cancers, including colon, head neck, NSCLC, liver, breast, ovarian cancer. As result, represents prospective target for cancer treatment. anti-EGFR thriving, notably dacomitinib, afatinib, erlotinib, gefitinib, osimertinib. However, almost all currently available limited therapeutic effectiveness due lack selectivity well substantial side effects. Furthermore, aberrant across numerous human malignancies/carcinomas is impeded gene amplification, protein overexpression, mutations, or in-frame deletions, making EGFR-induced treatment challenging. To overcome such, novel with high efficacy minimal toxicity required. battle resistance inhibitors, pyrazole, pyrazoline, their investigated viable pharmacophore development new better potency, lesser toxicity, favourable pharmacokinetic characteristics. The present investigation covers examination progress toward anti-cancer therapies via fused pyrazole-based compounds. current study also inclusive data on marketed candidates undergoing preclinical clinical Lastly, we discussed recent advances medicinal chemistry significance eradication various cancers provide direction structure-activity relationship (SAR), mechanistic studies.

Language: Английский

Citations

5
Antiangiogenic potential of phytochemicals from Clerodendrum inerme (L.) Gaertn investigated through in silico and quantum computational methods DOI

Nusrath Yasmeen,

Anis Ahmad Chaudhary,

Salauddin Khan

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: 29(1), P. 215 - 239

Published: April 28, 2024

Language: Английский

Citations

4