Heliyon,
Journal Year:
2024,
Volume and Issue:
10(4), P. e26351 - e26351
Published: Feb. 1, 2024
Alzheimer's
disease
is
a
neurological
disorder
that
causes
increased
memory
loss,
mood
swings,
behavioral
disorders,
and
disruptions
in
daily
activities.
Polymer
scaffolds
for
the
brain
have
been
grown
under
laboratory,
physiological,
pathological
circumstances
because
of
limitations
conventional
treatments
patients
with
central
nervous
system
diseases.
The
blood-brain
barrier
prevents
medications
from
entering
brain,
challenging
AD
treatment.
Numerous
biomaterials
such
as
biomolecules,
polymers,
inorganic
metals,
metal
oxide
nanoparticles
used
to
transport
therapeutic
medicines
into
system.
Incorporating
biocompatible
materials
support
neurogenesis
through
combination
topographical,
pharmacological,
mechanical
stimuli
has
also
shown
promise
transfer
cells
replenish
dopaminergic
neurons.
Components
made
naturally
occurring
biodegradable
polymers
are
appropriate
regeneration
nerve
tissue.
ability
natural-based
(biomaterials)
promote
endogenous
cell
development
after
implantation.
Also,
strategic
functionalization
polymeric
nanocarriers
could
be
employed
treating
AD.
In
particular,
resolve
Aβ
aggregation
thus
help
cure
disease.
Drug
moieties
can
effectively
directed
by
utilizing
nano-based
systems
diverse
colloidal
carriers,
including
hydrogels
scaffolds.
Notably,
early
investigations
employing
neural
stem
yielded
promising
results,
further
emphasizing
potential
advancements
this
field.
Few
studies
fully
leveraged
cutting-edge
biomaterials.
This
study
provides
comprehensive
overview
prior
research,
highlighting
pivotal
role
sophisticated
drug
carriers.
It
delves
various
intelligent
delivery
systems,
encompassing
pH
thermo-triggered
mechanisms,
lipid
nanoparticles,
other
vectors.
discussion
synthesizes
existing
knowledge
underscores
transformative
impact
these
devising
innovative
strategies,
augmenting
current
methodologies,
shaping
new
paradigms
realm
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(11)
Published: Sept. 25, 2023
The
novel
benzothiazole
sulfonate
hybrid
derivatives
containing
azomethine
group
were
synthesized
and
characterized
using
1
H-NMR,
13
C-NMR,
HR-MS
analysis.
potential
enzyme
inhibition
activities
against
pancreatic
lipase
of
the
screened
with
in
vitro
silico
methods.
IC50
values
compounds
5
b
(23.89
μM),
i
(28.87
f
(30.13±4.32)
found
to
be
more
effective
inhibitors
than
orlistat
(57.75
μM)
studies.
Also,
binding
affinities
(-8.7
kcal/mol),
(-8.6
(-8.9
kcal/mol)
for
In
addition,
absorption
distribution,
metabolism,
excretion
properties
(ADME),
molecular
properties,
toxicity
estimation,
bioactivity
scores
scanned.
It
was
have
ability
cross
brain-blood
barrier
a,
b,
c,
d.
All
calculated
taken
orally
as
drugs,
suitable
intestinal
tract
not
carcinogenic,
well
very
strongly
bound
plasma
proteins.
Finally,
compound
observed
best
inhibitor
according
