Considering
the
importance
of
field
green
chemistry
and
its
evolution
in
past
decades,
use
water
as
a
solvent
for
organic
transformations
has
become
more
relevant.
This
arises
from
fact
that
is
cheap,
nontoxic,
nonflammable,
readily
available
solvent.
Furthermore,
utilization
chemical
processes
additional
benefits
due
to
advantageous
physiochemical
properties,
such
hydrogen
bonding,
hydrophobic
effect,
polarity,
trans-phase
interactions,
high
cohesive
energy,
negative
activation
volume.
These
properties
render
compelling
attractive
candidate
viable
alternative
processes.
Notably,
water's
role
especially
pronounced
context
multicomponent
reactions
(MCRs),
it
been
shown
enhance
reaction
rates.
reduction
steps
hence
decrease
unit
operations,
MCRs
are
known
reduce
manpower,
costs,
time,
while
they
also
promote
atom
economy.
Performing
offers
sustainable
environmentally
friendly
approach
synthesis
bioactive
heterocyclic
compounds.
review
highlights
latest
advancements
isocyanide-
Knoevenagel-initiated
toward
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(50), P. 35500 - 35524
Published: Jan. 1, 2023
The
pandemic
caused
by
the
coronavirus
SARS-CoV-2
led
to
a
global
crisis
in
world
healthcare
system.
Despite
some
progress
creation
of
antiviral
vaccines
and
mass
vaccination
population,
number
patients
continues
grow
because
spread
new
mutations.
There
is
an
urgent
need
for
direct-acting
drugs
capable
suppressing
or
stopping
main
mechanisms
reproduction
SARS-CoV-2.
Several
studies
have
shown
that
successful
replication
virus
cell
requires
proteolytic
cleavage
protein
structures
virus.
Two
proteases
are
crucial
replicating
other
coronaviruses:
protease
(Mpro)
papain-like
(PLpro).
In
this
review,
we
summarize
essential
viral
proteins
required
its
life
cycle
as
targets
chemotherapy
infection
provide
critical
summary
development
against
COVID-19
from
drug
repurposing
strategy
up
molecular
design
novel
covalent
non-covalent
agents
inhibiting
replication.
We
overview
choice
Mpro
PLpro
promising
pharmacological
impact
on
cycle.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(15), P. 3961 - 3977
Published: Jan. 1, 2024
In
this
research,
new
catalytic
applications
of
the
Fe
3
O
4
/
f
-MWCNT-CS-Glu/Ni
II
nanocomposite
have
been
introduced
for
efficient
reduction
and
one-pot
two-step
reductive
Schotten–Baumann-type
acetylation
nitroarenes
in
water.
Journal of Heterocyclic Chemistry,
Journal Year:
2023,
Volume and Issue:
60(11), P. 1838 - 1863
Published: July 31, 2023
Abstract
Pyrimidine
annulated
five‐membered
heterocyclic
scaffolds
containing
oxygen
as
furopyrimidine,
particularly
furo[2,3‐
d
]pyrimidine
derivatives
are
an
important
class
of
compounds
in
pharmaceutical
discovery
research.
Furo[2,3‐
]pyrimidines
generally
synthesized
either
from
a
pyrimidine
derivative
by
constructing
furan
ring
on
the
parent
or
suitably
functionalized
generating
ring.
Moreover,
there
is
wide
range
multicomponent
reactions
that
include
barbituric
acids
starting
material
for
synthesis
these
compounds.
Also,
reaction
with
alkenes,
alkynes,
aldehydes,
ketones,
ninhydrin,
and
chloroacetylchloride,
Cloke–Wilson
rearrangement
spirocyclopropyl
barbiturates
afforded
derivatives.
This
review
attempt
to
compile
literature
various
synthetic
procedures
toward
acids‐based
spirofuro[2,3‐
]pyrimidines.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(2), P. 263 - 263
Published: Feb. 19, 2024
Recent
research
has
uncovered
a
promising
approach
to
addressing
the
growing
global
health
concern
of
obesity
and
related
disorders.
The
inhibition
inositol
hexakisphosphate
kinase
1
(IP6K1)
emerged
as
potential
therapeutic
strategy.
This
study
employs
multiple
ligand-based
in
silico
modeling
techniques
investigate
structural
requirements
for
benzisoxazole
derivatives
IP6K1
inhibitors.
Firstly,
we
developed
linear
2D
Quantitative
Structure–Activity
Relationship
(2D-QSAR)
models
ensure
both
their
mechanistic
interpretability
predictive
accuracy.
Then,
pharmacophore
was
performed
identify
essential
features
responsible
compounds’
high
activity.
To
gain
insights
into
3D
enhanced
potency
against
enzyme,
employed
alignment
set
up
3D-QSAR
models.
Given
absence
an
available
X-ray
crystal
structure
IP6K1,
reliable
homology
model
enzyme
structurally
validated
order
perform
structure-based
analyses
on
selected
dataset
compounds.
Finally,
molecular
dynamic
simulations,
using
docked
poses
these
compounds,
provided
further
insights.
Our
findings
consistently
supported
interpretations
derived
from
analyses.
offers
valuable
guidance
design
novel
Importantly,
our
work
exclusively
relies
non-commercial
software
packages,
ensuring
accessibility
reproducing
reported
