Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan-ZnO, and chitosan-ZnO/PVP nanoparticles DOI Creative Commons

Abdelatif Aouadi,

Djamila Hamada Saoud,

Abdelkrim Rebiai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Abstract The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability procedure for synthesizing such is inadequate. Consequently, green biosynthesis, which employs biopolymers, gaining attraction as an environmentally sound alternative to less sustainable approaches. Chitosan-encapsulated exhibit exceptional antibacterial properties, offering a wide range uses. Chitosan, obtained from shrimp shells, aided friendly synthesis high-purity zinc oxide (ZnO NPs) with desirable features extraction yield (41%), deacetylation (88%), crystallinity index (74.54%). particle size ZnO NPs was 12 nm, while that chitosan-ZnO 21 bandgap energies these were 2.5 2.3, respectively. strong action demonstrated NPs, chitosan-ZnO/PVP, particularly against Gram-positive bacteria, making them appropriate therapeutic use. photocatalytic degradation abilities also assessed all nanoparticles. At concentration 6×10− 5 M, chitosan removed 90.5% methylene blue (MB) dye, 97.4%, chitosan-coated 99.6%, chitosan-ZnO/PVP 100%. In case toluidine (TB), at 4×10− 3 respective efficiencies 96.8%, 99.5%, 100%, Moreover, in sillico studies conducted predict organ-specific through ProTox II software. results three tested samples completely safe showed no toxicity.

Language: Английский

Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles DOI Creative Commons

Abdelatif Aouadi,

Djamila Hamada Saud,

Abdelkrim Rebiai

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 26, 2024

The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability procedure for synthesizing such is inadequate. Consequently, green biosynthesis, which employs biopolymers, gaining attraction as an environmentally sound alternative to less sustainable approaches. Chitosan-encapsulated exhibit exceptional antibacterial properties, offering a wide range uses. Chitosan, obtained from shrimp shells, aided friendly synthesis high-purity zinc oxide (ZnO NPs) with desirable features extraction yield (41%), deacetylation (88%), crystallinity index (74.54%). particle size ZnO NPs was 12 nm, while that chitosan-ZnO 21 bandgap energies these were 3.98 3.48, respectively. strong action demonstrated NPs, chitosan-ZnO/PVP, particularly against Gram-positive bacteria, making them appropriate therapeutic use. photocatalytic degradation abilities also assessed all nanoparticles. At concentration 6 × 10

Language: Английский

Citations

17
Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles DOI
Salma M. Hefny, Tarek F. El‐Moselhy,

Nabaweya Sharaf El-Din

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(9), P. 7406 - 7430

Published: April 20, 2024

A dual-targeting approach is predicted to yield better cancer therapy outcomes. Consequently, a series of coumarin-based thiazoles (5a–h, 6, and 7a–e) were designed constructed as potential carbonic anhydrase (CA) VEGFR-2 suppressors. The inhibitory actions the target compounds assessed against CA isoforms IX VEGFR-2. assay results showed that 5a, 5d, 5e can effectively inhibit both targets. cytotoxic effects tested on pancreatic, breast, prostate cells (PANC1, MCF7, PC3). Further mechanistic investigation disclosed ability interrupt PANC1 cell progression in S stage by triggering apoptotic cascade, seen increased levels caspases 3, 9, BAX, alongside Bcl-2 decline. Moreover, vivo efficacy compound an antitumor agent was evaluated. Also, molecular docking dynamics displayed distinctive interactions between binding pockets.

Language: Английский

Citations

13
Novel imidazolone derivatives as potential dual inhibitors of checkpoint kinases 1 and 2: Design, synthesis, cytotoxicity evaluation, and mechanistic insights DOI

Yasmin S. Sheta,

Marwa T. Sarg, Fatma G. Abdulrahman

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 149, P. 107471 - 107471

Published: May 19, 2024

Language: Английский

Citations

4
Exploring 1,2,3-triazole-Schiff’s base hybrids as innovative EGFR inhibitors for the treatment of breast cancer: In vitro and in silico study DOI

Nareman A. Nawareg,

Asmaa S. A. Yassen, Ebtehal M. Husseiny

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108106 - 108106

Published: Jan. 4, 2025

Language: Английский

Citations

0
A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules DOI
Hamada S. Abulkhair, Khaled El‐Adl

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Because of its importance in medicinal chemistry, scientific researchers have been interested incorporating sulfamethazine developing biologically active candidates. To achieve this, several synthetic approaches adopted. The adopted included condensation with electrophilic reactants, coupling nucleophilic aromatics and methylene compounds, Knoevenagel condensation, Doebner Miller reaction, microwave‐assisted click cycloaddition, green reaction routes, multicomponent reaction. Linking this molecular scaffold to a variety heterocycles the last 10 years furnished set potential anti‐inflammatory, antiviral, anticancer, antiparkinsonian, neuroprotective, antidiabetic candidates targeting H5N1 NA, epidermal growth factor receptor, acetylcholinesterase (AChE), butylcholinesterase (BChE), human carbonic anhydrase ( h CA), α‐amylase, α‐glucosidase. This review reports all approaches, biological activities studied, structure‐activity relationship analyses, mechanistic investigations reported organic sulfamethazine‐incorporating molecules throughout 2015–2024, based on information retrieved from three search engines: Scopus, PubMed, Google Scholar.

Language: Английский

Citations

0
Comparison between conventional, grinding, and microwave synthesis of methylpyrazoles as VEGFR-2/HSP90 dual inhibitors DOI
Ebtehal M. Husseiny, Rana M. Abdelnaby, Najla Altwaijry

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 31, 2025

Aim Embracing structure extension and substitution variation, methylpyrazolones 2–6 dimethylpyrazoles 8–14 were synthesized as VEGFR-2/HSP90 dual inhibitors.

Language: Английский

Citations

0
In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties DOI
Ebtehal M. Husseiny, Hamada S. Abulkhair, Samiha A. El‐Sebaey

et al.

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Nov. 12, 2024

The structural optimization of our recently reported CDK9 inhibitor to furnish novel aminopyrazolones and methylpyrazolones with improved pharmacokinetics.

Language: Английский

Citations

3
Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan-ZnO, and chitosan-ZnO/PVP nanoparticles DOI Creative Commons

Abdelatif Aouadi,

Djamila Hamada Saoud,

Abdelkrim Rebiai

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Abstract The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability procedure for synthesizing such is inadequate. Consequently, green biosynthesis, which employs biopolymers, gaining attraction as an environmentally sound alternative to less sustainable approaches. Chitosan-encapsulated exhibit exceptional antibacterial properties, offering a wide range uses. Chitosan, obtained from shrimp shells, aided friendly synthesis high-purity zinc oxide (ZnO NPs) with desirable features extraction yield (41%), deacetylation (88%), crystallinity index (74.54%). particle size ZnO NPs was 12 nm, while that chitosan-ZnO 21 bandgap energies these were 2.5 2.3, respectively. strong action demonstrated NPs, chitosan-ZnO/PVP, particularly against Gram-positive bacteria, making them appropriate therapeutic use. photocatalytic degradation abilities also assessed all nanoparticles. At concentration 6×10− 5 M, chitosan removed 90.5% methylene blue (MB) dye, 97.4%, chitosan-coated 99.6%, chitosan-ZnO/PVP 100%. In case toluidine (TB), at 4×10− 3 respective efficiencies 96.8%, 99.5%, 100%, Moreover, in sillico studies conducted predict organ-specific through ProTox II software. results three tested samples completely safe showed no toxicity.

Language: Английский

Citations

1