Chemical Physics Letters, Journal Year: 2024, Volume and Issue: 857, P. 141725 - 141725
Published: Oct. 25, 2024
Language: Английский
Chemical Biology & Drug Design, Journal Year: 2025, Volume and Issue: 105(3)
Published: March 1, 2025
Infections caused by Gram-negative bacteria within the ESKAPE group pose significant treatment challenges. These feature effective efflux pumps and possess lipopolysaccharides in their outer membranes, as well a thin peptidoglycan layer measuring 5-10 nm thickness. Acinetobacter baumannii (A. baumannii), bacterium, is contributor to serious infections acquired hospitals communities, representing substantial risk human health. This bacterium has developed resistance nearly all existing antibiotics, past 50 years, no new antibacterial class been introduced for treating A. infections, highlighting an urgent necessity development of antibacterials. The unique structural framework adaptable features pyrazole ring attract researchers develop antibiotics. present study outlines advancements made over last decade pyrazole-containing derivatives that exhibit wide range activity against various bacterial strains. Specifically, we discuss effectiveness diverse multidrug-resistant strains explore aspects structure-activity relationship (SAR). compilation data could serve excellent platform designing developing pyrazole-based small molecules target growth baumannii.
Language: Английский
Citations
0
Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)
Published: March 1, 2025
Acinetobacter baumannii is one of the major causes severe hospital- and community-acquired infections, posing a significant threat to human lives. A. has already generated resistance almost all currently available antibiotics, but no new class antibacterials have been launched for treatment infections caused by in last half century, creating an urgent need develop novel antibacterials. Azoles as broad five-membered nitrogen-containing aromatic heterocycles are privileged pharmacophores widely found pharmaceuticals. could target on diverse enzymes, proteins, receptors via various noncovalent interactions. Particularly, azole hybrids potential advantages increasing therapeutic efficacy circumventing drug resistance, representing useful scaffolds discovery anti-A. agents. This review outlines current scenario antibacterial against baumannii, developed from 2020 onwards, aiming provide candidates further preclinical/clinical evaluations facilitate rational design more effective candidates.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 20, 2025
Public health is seriously threatened by the rise of antibiotic-resistant strains bacteria, especially methicillin resistant Staphylococcus aureus (MRSA). This study investigated phytochemical compounds, and possible antibacterial effects a methanolic extract cactus species Opuntia monacantha Haw. against MRSA. The powdered substance was extracted with methanol filtered, filtrate partitioned n-hexane, chloroform ethyl acetate. fractions higher percentage yields such as n-hexane went through GC-MS analysis. They consist various compounds that are known to have strong antioxidant antimicrobial activities. activity plant measured via diffusion assay. On basis these results, crude extract, significantly inhibited all MRSA used in test at 100, 75 50 mg/mL. Furthermore, minimum inhibitory concentrations were also examined. Therefore, could be promising candidate for strengthening existing formulations pharmaceutical science treatment However, additional research necessary before its therapeutic use recommended. results intended provide important new information creation sustainable alternative agents.
Language: Английский
Citations
0
ChemistryOpen, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract This review manuscript examines magnetic nanocatalysts and their pivotal role in forming carbon‐sulfur (C−S) carbon‐selenium (C−Se) bonds. The study delves into the latest advancements synthesis, characterization, application of nanocatalysts, highlighting unique advantages, including enhanced catalytic activity, superior selectivity, easy recovery through separation, which align with principles green chemistry. Through a critical analysis recent research findings, this also explores mechanistic pathways facilitated by these offering insights operational efficiency potential for recyclability. aims not only to catalog current achievements burgeoning field but identify challenges propose future directions developing more efficient, sustainable, versatile systems C−S C−Se bond formation. By encompassing broad spectrum ranging from bare magnets functionalized composite materials, is comprehensive resource researchers engaged organic catalysis, sustainable
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
The study aims to synthesize, characterize, and evaluate a series of novel compounds for their potential anticancer activity targeting the A549 lung cancer cell line. hydrazonothiazole-based pyridine (2a-2o) were characterized through melting point analysis, 1H NMR, 13C high-resolution mass spectrometry (HRMS). Their physicochemical properties evaluated using in silico tools, all found comply with Lipinski's drug-likeness rule, suggesting favorable drug-like characteristics. Biological studies revealed that synthesized exhibited potent cytotoxicity against line, several showing greater efficacy than standard drug, cisplatin. Selectivity indices also calculated, revealing 2b, 2c, 2f, 2m enhanced selectivity cells relative healthy cells. Mechanistic flow cytometry demonstrated these induced apoptosis, compound demonstrating highest apoptotic activity. Mitochondrial membrane assay caspase-3 activation confirmed involvement mitochondrial pathways apoptosis induction. Furthermore, MMP-9 enzyme inhibition assays identified 2f as most effective inhibitor, molecular docking dynamics simulation confirming its strong binding interactions key residues enzyme's active site. Overall, this suggests compounds, particularly 2m, hold promise agents further development optimization treatment cancer.
Language: Английский
Citations
0
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 292, P. 117715 - 117715
Published: May 1, 2025
Language: Английский
Citations
0
American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(7), P. 2814 - 2827
Published: Jan. 1, 2024
To assess the efficacy of targeted therapy based on drug sensitivity testing (DST) results in patients with acute pulpitis (AP).
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 107986 - 107986
Published: Nov. 22, 2024
Language: Английский
Citations
0
Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(10)
Published: July 10, 2024
Acinetobacter baumannii with the capability to "escape" almost all currently available antibacterials is eroding safety of basic medical interventions and an increasing cause mortality globally, prompting a substantial requirement for new classes antibacterial agents. Indoles participate in regulation persistent bacterial formation, biofilm plasmid stability, drug resistance. In particular, indole hybrids demonstrated promising activity against both drug-sensitive drug-resistant A. pathogens, representing fertile source discovery novel therapeutic agents clinical deployment controlling infections. This mini-review outlines current innovations covering articles published from 2020 present, open avenues exploring anti-A. candidates.
Language: Английский
Citations
0
Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(11)
Published: Oct. 14, 2024
ABSTRACT Burns are one of the most common injuries in both civilian and combat settings difficult to treat. This is particularly true when wounds infected with antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). A new generation safe, broadly effective, easily applied anti-infection agents needed successfully prevent treat infections. Nanoemulsions (NEs) nanometer-sized particles a positively charged surfactant at their oil-water interface. In current study, we further investigated antimicrobial NEs treatment address burn by MRSA. Specifically, using porcine skin model, partial thickness thermal MRSA then treated it nanoemulsion formulation (NB-201) or placebo controls. Bacterial viability after was determined, inflammation indexes were scored histopathology. Topical NB-201 resulted reduced colony-forming units (CFUs) compared treatment. addition, effective significantly alleviating promoting wound healing. These results indicate that promising agent IMPORTANCE The findings this study focused on therapeutic applications nanotechnology. demonstrated could effectively kill (MRSA) infection wounds. Infection threat public health usually due limited therapies available. Therefore, finding has great potential make novel against
Language: Английский
Citations
0