Investigating the Antiproliferative Activity of Novel 4‐Chloro‐8‐Nitro‐1,2‐Dihydro‐3‐Quinoline Acylhydrazones on Human Cervical Cancer Cell Lines DOI Open Access
Vandana Nandakumar, Sentamil Selvi Ramasamy,

Kaviyarasu Adhigaman

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

A new series of acyl hydrazones have been synthesized from 4-chloro-8-nitro-1,2-dihydroquinoline-3-carbaldehyde. These compounds were characterized using various spectroscopic techniques. Density functional theoretical (DFT) studies conducted to understand the correlation between electronic parameters and biological activity. The activity was theoretically examined through molecular docking ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) analysis. demonstrated high absorption rates found be non-hepatotoxic. Preliminary cytotoxicity screenings against HeLa cell lines identified compound 7 as most potent, with an IC

Language: Английский

Novel purine derivatives as selective CDK2 inhibitors with potential anticancer activities: Design, synthesis and biological evaluation DOI

Alpesh D. Shah,

Nishith Teraiya, Jignesh H. Kamdar

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107841 - 107841

Published: Sept. 24, 2024

Language: Английский

Citations

4
Discovery of new pyrazole-4-carboxamide analogues as potential anticancer agents targeting dual Aurora kinase A and B DOI

Digambar Yevale,

Nishith Teraiya,

Twinkle Lalwani

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116917 - 116917

Published: Oct. 4, 2024

Language: Английский

Citations

4
Bio-functionalization of Chitosan@Ag nanoparticles using Terminalia arjuna and their antioxidant, antibacterial and cytotoxic activity DOI

Sangeeta Khichar,

Shubham Dashora,

Dharti Patel

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140507 - 140507

Published: Jan. 29, 2025

Language: Английский

Citations

0
Discovery of novel benzoxazole analogues as potential anticancer agent selectively targeting aromatase DOI

Sandip Gadakh,

Balasaheb D. Aghav, Nishith Teraiya

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118142 - 118142

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis of Novel Pyridazine and Pyrimidine linked Pyrazole derivatives as DNA Ligase 1 and IV inhibitors that induce apoptosis DOI

S. Aishwarya,

Gabriela C Torres,

Jose A Lopez-Saenz

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111509 - 111509

Published: April 1, 2025

Language: Английский

Citations

0
2-Ferrocene-4-amine-1H-benzo[d]imidazole and their derivatives: Synthesis, biological and docking study DOI
Mukesh Kawad,

Sagar R. Sangani,

Jigneshkumar Parmar

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: unknown, P. 117242 - 117242

Published: Oct. 1, 2024

Language: Английский

Citations

0
Non-nucleophilic base promoted synthesis of azo-linked oxazolone-pyrazole hybrids: Antimicrobial, antitubercular, anticancer evaluations and in-silico modeling insights DOI Creative Commons
Bonny Y. Patel,

Vidhi Joshi,

Sangeetha Subramanian

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 12, P. 101887 - 101887

Published: Nov. 7, 2024

Language: Английский

Citations

0
Investigating the Antiproliferative Activity of Novel 4‐Chloro‐8‐Nitro‐1,2‐Dihydro‐3‐Quinoline Acylhydrazones on Human Cervical Cancer Cell Lines DOI Open Access
Vandana Nandakumar, Sentamil Selvi Ramasamy,

Kaviyarasu Adhigaman

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

A new series of acyl hydrazones have been synthesized from 4-chloro-8-nitro-1,2-dihydroquinoline-3-carbaldehyde. These compounds were characterized using various spectroscopic techniques. Density functional theoretical (DFT) studies conducted to understand the correlation between electronic parameters and biological activity. The activity was theoretically examined through molecular docking ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) analysis. demonstrated high absorption rates found be non-hepatotoxic. Preliminary cytotoxicity screenings against HeLa cell lines identified compound 7 as most potent, with an IC

Language: Английский

Citations

0