SYNTHESIS OF NEW IMINE COMPOUNDS BEARING INDOLE AND 1,3,4-THIADIAZOLE MOIETIES: SPECTRAL PROPERTIES, DFT STUDIES, TAUTOMERISM AND BOND ANALYSIS DOI
Sevil Özkınalı, M. Serdar Çavuş,

Tuğçe Tosun

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140901 - 140901

Published: Nov. 1, 2024

Language: Английский

Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands DOI
X. Ben Wu, Lifang Wu,

Z. W. Li

et al.

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

1
Synthesis of Novel α-Carboxylate-β-Bismethylsulfanyl Pyrazolyl Schiff Base Derivatives: Targeting DNA gyrase in Antibacterial activity DOI
Ankita Garg,

Dolar Dureja,

Anjali Vijeata

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141954 - 141954

Published: March 1, 2025

Language: Английский

Citations

1
Stereoselective synthesis and antibacterial potential of C-3 chloro β-lactams: Insights into DNA gyrase inhibition using in silico molecular docking DOI
Ankita Garg,

Preety Saini,

Anjali Vijeata

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142713 - 142713

Published: March 1, 2025

Language: Английский

Citations

1
Recent progress in synthetic strategies for novel β-lactams linked with five-membered heterocycles (N/O/S): advances in medicinal chemistry (2020–2025) DOI

Ankita Garg,

Dolar Dureja,

Raaina Pasricha

et al.

Medicinal Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

Citations

0
Design, Synthesis and Biological Evaluation of C3‐Indolyl/(3‐chloro‐indolyl)‐C4‐aryl/heteroaryl‐azetidin‐2‐ones DOI
Pooja Yadav,

Nasreen Fatimah,

Subash Chandra Sahoo

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(17)

Published: May 31, 2024

Abstract Herein, trans‐ and cis‐ azetidin‐2‐ones 3–6 were strategically synthesized, capitalizing on the bioactivity of indole pharmacophore, followed by a comprehensive characterization using diverse array spectroscopic techniques. The sixteen examined for antimicrobial activities against both Gram‐negative ( P. aeruginosa , E. coli A. baumannii ) Gram‐positive bacteria (S . aureus, faecium, B. cereus ), as well C. albicans tropicalis fungal strains. highly potent compounds 5 6 b d demonstrated maximum inhibition all multidrug‐resistant strains, with minimum inhibitory concentrations ranging from 0.97–3.9 μg/mL, surpassing potency standard ampicillin (MIC: 3.12–50 μg/mL). Moreover, exhibited significant effects 0.97 μg/mL), comparable to fluconazole. presence C3 ‐(3‐chloro‐indolyl) scaffold, combined electronic at N1/C4 ‐centers, particularly inclusion thiophen‐2‐yl motif, greatly influenced activity target compounds. Assessment 4 i–k THLE‐2 cell lines revealed their preferential safety. Molecular docking studies seven active dual targeting DNA GyrB PBP2a proteins, demonstrating broad‐spectrum antibacterial effect. In silico ADME analysis affirms positive drug‐likeness favorable pharmacokinetic characteristics indole‐derived hybrids, indicating promising potential addressing challenges in evolving multidrug resistance.

Language: Английский

Citations

3
An insights into structural diversity of β-lactam scaffold towards varied medicinal applications: A comprehensive update (2020–2024) DOI
Ankita Garg,

Teesha Thakral,

Radhakrishan Dhiman

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 153, P. 155383 - 155383

Published: Nov. 16, 2024

Language: Английский

Citations

2
Emerging Trends in Microwave and Ultrasound/Visible Light/ Carbene Intermediates & Carbonylation/Metal-Catalyzed Mediated Synthesis of β-Lactams (2021-2024) DOI

Ankita Garg,

Radhakrishan Dhiman,

Teesha Thakral

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: unknown, P. 134429 - 134429

Published: Dec. 1, 2024

Language: Английский

Citations

1
SYNTHESIS OF NEW IMINE COMPOUNDS BEARING INDOLE AND 1,3,4-THIADIAZOLE MOIETIES: SPECTRAL PROPERTIES, DFT STUDIES, TAUTOMERISM AND BOND ANALYSIS DOI
Sevil Özkınalı, M. Serdar Çavuş,

Tuğçe Tosun

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140901 - 140901

Published: Nov. 1, 2024

Language: Английский

Citations

0