COVID-19 drugs: a critical review of physicochemical properties and removal methods in water

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: 13(1), P. 115310 - 115310

Published: Jan. 5, 2025

Language: Английский

Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 491 - 491

Published: Jan. 23, 2025

The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage immune evasion, making it prime target for therapeutic intervention. Numerous compounds have been identified as inhibitors of SARS-CoV-2 PLpro, with many characterized through crystallographic studies. To date, over 70 three-dimensional (3D) structures PLpro complexed ligands deposited Protein Data Bank, offering valuable insight into ligand-binding features that could aid discovery development effective treatments targeting PLpro. In this study, we reviewed analyzed these 3D structures, focusing on key residues involved ligand interactions. Our analysis revealed most bind to PLpro’s substrate recognition sites S3/S4 SUb2. While are highly attractive extensively explored, other potential binding regions, such SUb1 Zn(II) domain, less explored may hold untapped future drug development. structural provides insights molecular accelerate therapeutics essential enzyme.

Language: Английский

Inhibition of hostN-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 3, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which caused the disease 2019 (COVID-19) pandemic, remains a global health concern despite vaccines, neutralizing antibodies, and antiviral drugs. Emerging mutations can reduce effectiveness of these treatments, suggesting that targeting host cell factors may be valuable alternative. N -myristoyltransferases (NMT) are essential enzymes for protein -myristoylation, affecting stability, interaction, localization, function numerous proteins. We demonstrate selective inhibition NMT decreases SARS-CoV-2 infection by 90% in human lung primary nasal epithelial cells, choroid plexus-cortical neuron organoids. does not affect viral entry, replication or release, but impairs maturation incorporation envelope proteins into newly assembled virions, leading to compromised infectivity released virions. The triggers Golgi-bypassing pathway progeny virion egress, occurs through endoplasmic reticulum lysosomal intermediates.

Language: Английский