Synthesis of new 1,4-benzodioxin derivatives containing thiazolidin-4-one skeleton, molecular modelling and docking as antibacterial agents DOI

Xiao‐Meng Guo,

Cai‐Shi Liu,

Jin-Peng Tong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140424 - 140424

Published: Oct. 1, 2024

Language: Английский

Synthesis of polysubstituted spiroazepines via [4 + 3] annulation reaction of ninhydrin-derived Morita−Baylis−Hillman carbonates with 1‑heterodienes DOI
Kai‐Kai Wang, Yafei Li, R. Bi

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141478 - 141478

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synthesis, In Vitro Antimicrobial Activities, Molecular Docking, and ADMET Studies of Hydrazone‐Schiff Bases Bearing Ibuprofen Scaffold DOI
Muhammad Ayaz, Aftab Alam,

Zainab Zainab

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract In this research, we explore the synthesis and in vitro antibacterial activity of hydrazone Schiff base derivatives bearing ibuprofen nucleus. These were synthesized by treating with hydrazine hydrate presence 1,1‐carbonyldiimidazole (CDI) tetrahydrofuran (THF). The obtained hydrazide was further treated various benzaldehydes ethanol solvent containing acetic acid as a catalyst to get desired bases good yields. Structures these have been structurally deduced means modern spectroscopic techniques (FT‐IR, mass, 1 H‐NMR, 13 C‐NMR) screened against Gram‐positive andGram‐negative strains (ATCC) including Escherichia coli (ATCC 25922), Klebsiella pneumoniae BAA‐1705), Staphylococos aureus 33862), Pseudomonas aeruginosa 15442) quiet diverse results observed. All compounds series presented significant levels inhibition all tested (MIC range 0.019 1.25 mg/mL). Most active reported 2a 0.78 mg/mL) 2d (0.019 g/mL). Molecular docking investigation performed know binding interactions targeted enzyme's site.

Language: Английский

Citations

0
Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents DOI
Mehran Ghasemi, Aida Iraji, Maryam Dehghan

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107908 - 107908

Published: Oct. 30, 2024

Language: Английский

Citations

3
Novel Quinolin-4-ylcarbonylhydrazine Having N-(3-Arylacryloyl) Moiety: Design, Synthesis and Biological Evaluation as Potential Cytotoxic Agents against MDA-MB-231 via Tubulin Assembly Inhibition DOI
Hany M. Abd El‐Lateef,

Tahani H. Alharbi,

Eman Fayad

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 140214 - 140214

Published: Sept. 27, 2024

Language: Английский

Citations

1
Synthesis of new 1,4-benzodioxin derivatives containing thiazolidin-4-one skeleton, molecular modelling and docking as antibacterial agents DOI

Xiao‐Meng Guo,

Cai‐Shi Liu,

Jin-Peng Tong

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140424 - 140424

Published: Oct. 1, 2024

Language: Английский

Citations

1