Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 11, 2025

ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.

Language: Английский

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Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 114, P. 129992 - 129992

Published: Oct. 18, 2024

Language: Английский

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Electron-reservoir applications of ferrocenes and other late transition-metal sandwich complexes: Flow batteries, sensing, catalysis, and biomedicine

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 524, P. 216300 - 216300

Published: Nov. 9, 2024

Language: Английский

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