Enhancing antimicrobial activity through structural modification of Rip-thanatin with amino acid substitution
Microbial Pathogenesis,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107501 - 107501
Published: March 1, 2025
Language: Английский
Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides
Biotechnology and Bioengineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
ABSTRACT
Antibacterial
resistance
has
emerged
as
a
significant
global
concern,
necessitating
the
urgent
development
of
new
antibacterial
drugs.
Antimicrobial
peptides
(AMPs)
are
naturally
occurring
found
in
various
organisms.
Coupled
with
wide
range
activity,
AMPs
less
likely
to
develop
drug
and
can
act
potential
agents
for
treating
bacterial
infections.
However,
their
characteristics,
such
low
instability,
toxicity,
hinder
clinical
application.
Consequently,
researchers
inclined
towards
artificial
design
optimization
based
on
natural
AMPs.
This
review
discusses
research
advancements
field
designing
Moreover,
it
highlights
strategies
peptides,
aiming
provide
valuable
insights
developing
novel
Language: Английский
Propolis extract and Hermetia illucens larval proteins synergistically inhibit the growth of Aspergillus niger
Food Bioscience,
Journal Year:
2024,
Volume and Issue:
61, P. 104661 - 104661
Published: July 5, 2024
Language: Английский
Stapled Peptides: An Innovative and Ultimate Future Drug Offering a Highly Powerful and Potent Therapeutic Alternative
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(9), P. 537 - 537
Published: Sept. 5, 2024
Peptide-based
therapeutics
have
traditionally
faced
challenges,
including
instability
in
the
bloodstream
and
limited
cell
membrane
permeability.
However,
recent
advancements
α-helix
stapled
peptide
modification
techniques
rekindled
interest
their
efficacy.
Notably,
these
developments
ensure
a
highly
effective
method
for
improving
stability
enhancing
penetration.
Particularly
realm
of
antimicrobial
peptides
(AMPs),
application
has
significantly
increased
been
successfully
applied
to
many
peptides.
Furthermore,
constraining
secondary
structure
also
proven
enhance
biological
activity.
In
this
review,
entire
process
through
which
hydrocarbon-stapled
attain
improved
drug-like
properties
is
examined.
First,
essential
structural
elements
required
activity
as
drugs
are
validated,
specific
residues
identified
using
alanine
scanning,
stapling
strategically
incorporated
at
precise
locations.
Additionally,
mechanisms
by
structure-based
function
AMPs
explored,
providing
comprehensive
engaging
discussion.
Language: Английский
Effects of the Tobacco Defensin NaD1 Against Susceptible and Resistant Strains of Candida albicans
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1092 - 1092
Published: Dec. 10, 2024
Today,
Candida
albicans
is
still
the
most
common
cause
of
both
local
and
life-threatening
systemic
candidiasis.
The
spread
resistant
fungal
strains
has
resulted
in
an
urgent
need
to
search
for
new
promising
antimycotics.
Here,
we
investigated
antifungal
action
tobacco
defensin
NaD1
against
susceptible
azoles
echinocandins
C.
albicans.
We
demonstrated
that
was
equally
effective
fungicidal
all
tested
strains.
MIC
MFC
values
were
6.25
12.5
µM,
respectively.
showed
first
time
could
act
synergistically
not
only
with
caspofungin
but
also
human
host
defense
antimicrobial
peptides
cathelicidin
LL-37
β-defensin-2
(HBD2)
Using
flow
cytometry,
combinations
or
HBD2
can
reinforce
each
other
by
enhancing
membrane
disruption.
Caco-2
cell
monolayer
model,
impaired
adhesion
cells
epithelium.
Moreover,
inhibited
formation
biofilms
Sabouraud
broth
less
markedly
nutrient-rich
RPMI-1640
medium,
enhanced
antibiofilm
activity
caspofungin.
Thus,
hypothesized
might
affect
development
candidiasis
vivo,
including
caused
Language: Английский