Discovery and optimization of 4-(imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine derivatives as novel phosphodiesterase 4 inhibitors DOI

Zongmin Wu,

Furong Zhang,

Zhexin Chen

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers DOI
Heba K. Abd El-Mawgoud, Asmaa M. AboulMagd, Mohamed T. M. Nemr

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107622 - 107622

Published: July 9, 2024

Language: Английский

Citations

13
Novel benzenesulfonamide derivatives as potential selective carbonic anhydrase IX, XII inhibitors with anti-proliferative activity: Design, synthesis and in silico studies DOI

Wael A.A. Fadaly,

Fatma El Zahraa Ammar Mohamed, Mohamed T. M. Nemr

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107881 - 107881

Published: Oct. 10, 2024

Language: Английский

Citations

11
Synthesis of tetra-substituted thiophene derivatives as potential Hits combating antibiotic resistant bacteria ESKAPE DOI
Heba K. Abd El-Mawgoud, Asmaa M. AboulMagd, Ahmed Shaker

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108101 - 108101

Published: Jan. 8, 2025

Language: Английский

Citations

1
Design, synthesis, and in-Silco ADME prediction of some novel bis(1,3,4-thiadiazoles) encapsulated lipid chitosan nano capsule decorative with magnetic nanoparticles and their potential anti-helicobacter pylori activity DOI
Mostafa E. Salem, Ahmed H. M. Elwahy, Hamdi M. Hassaneen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139746 - 139746

Published: Jan. 1, 2025

Language: Английский

Citations

1
Insight Study For Repurposing Of Certain Anti‐Inflammatory Drugs Based On Aspirin and Salicylic Acid Scaffolds For The Treatment of Cancer as CDKs Inhibitors: Cheminformatics and Anticancer Studies DOI
Mohnad Abdalla, Ahmed E. Elmasry, Mohamed T. M. Nemr

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract The highly increased and global mortality due to cancer has created an urgent need discover promising targets for its treatment. Where drug repurposing was considered as attractive approach that can facilitate the lead generation optimization phases of discovery by existing agents target diseases other than their primary uses. Cheminformatics studies represented in molecular docking well dynamic simulation salicylic acid / aspirin analogues sulindac indomethacin anti‐inflammatory drugs were carried out be used cyclin‐dependent kinases (CDKs) namely CDK2, CDK6, CDK12 inhibitors. Sulindac displayed best binding ligand all receptors. CDKs inhibition effects three sulindac, anthranilic demonstrated good inhibitory activity against ranging from 0.48 1.78 µM. Likewise, cytotoxicity revealed potent anticancer 0.155 1.278 µM cell lines: HCT‐116, MCF‐7, HeLa cells. As a result, this technique saves lot time money order new agents.

Language: Английский

Citations

1
Nitrogen, Oxygen, and Sulphur Heterocycles as Potent Anti‐Inflammatory Agents: Insight Into the Synthetic Routes DOI Open Access

Mariam Khadri,

Uday Shashikumar, Pei‐Chien Tsai

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(9)

Published: March 1, 2025

Abstract Nitrogen, oxygen, and sulfur‐containing heterocyclic compounds are broadly established as key scaffolds with potential chemical biological properties. Benzimidazole, indole, benzoxazole, benzothiazole, pyrazole, thiophene analogs significant motifs that bear almost all pharmacological activities. Anti‐inflammatory activity is one of the most commonly associated activities these heterocycles thus has attracted interest researchers to synthesize study them in‐depth. The present review highlights mainly various synthetic methodologies utilized prepare diverse their properties limited anti‐inflammatory Further, this will provide a comprehensive idea used biologically active nitrogen, sulfur‐bearing possibly invoke new thoughts in search for rational designs developing more promising agents.

Language: Английский

Citations

0
Friedländer reactions for annulated pyrido[2,3-d]pyrimidines: Synthesis, structure characterization, anticancer and computational studies DOI
Al‐Shimaa Badran, Magdy A. Ibrahim,

Zeinab Hussain

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134608 - 134608

Published: March 1, 2025

Language: Английский

Citations

0
Recent advancements of pyrimidine chemistry thriving deeper into drug discovery DOI
Glanish Jude Martis,

O Sneha,

Rajkumar Bhat D

et al.

Synthetic Communications, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: April 3, 2025

Language: Английский

Citations

0
Synthesis and evaluation of carmofur analogs as antiproliferative agents, inhibitors to the main protease (Mpro) of SARS-CoV-2, and membrane rupture-inducing agents DOI Creative Commons

Tiffany Gu,

Ailing Lu, Xina Wang

et al.

Discover Chemistry., Journal Year: 2025, Volume and Issue: 2(1)

Published: April 7, 2025

Language: Английский

Citations

0
Design and synthesis of new pyrazole hybrids linked to oxime and nitrate moieties as COX-2, EGFRL858R/T790M inhibitors and nitric oxide donors with dual anti-inflammatory/anti-proliferative activities DOI

Wael A.A. Fadaly,

Mohamed T. M. Nemr, Abeer M. Abd El-Hameed

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 161, P. 108563 - 108563

Published: May 9, 2025

Language: Английский

Citations

0