Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107776 - 107776
Published: Sept. 3, 2024
Language: Английский
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 13, 2024
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence observed in patients treated with paclitaxel due resistance emergence. Resistant mechanisms are cells paclitaxel, docetaxel, cabazitaxel including changes the target molecule β-tubulin of mitosis, molecular that activate efflux drug out cells, alterations regulatory proteins apoptosis. This review discusses new taxane resistance, such as overexpression genes like multidrug EDIL3, ABCB1, MRP1, TRAG-3/CSAG2 genes. Moreover, significant lncRNAs detected lncRNA H19 cross-resistance between taxanes. contributed discovering treatment strategies for increasing responsiveness toward chemotherapeutic drugs.
Language: Английский
Citations
16
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354
Published: Oct. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Language: Английский
Citations
13
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 26, 2025
Background Chronic heart failure (CHF) is one of the leading causes high mortality worldwide. It characterized by pathological hypertrophy and poses a major threat to human health. Aconiti Lateralis Radix Praeparata widely used in ancient China treat CHF. However, pathology obscured, necessitating further exploration. Methods Prospective targets were predicted network analysis. A transverse aortic constriction (TAC) mice model was subsequently constructed determine effects aqueous extract (AEA) on The echocardiography performed investigate cardiac function. Histopathological analysis tissue conducted assess myocardial fibrosis. Nontargeted metabolomics analyze serum metabolites. phosphorylation level PI3K AKT, downstream such as Bnip3, p62, Atg5, LC3II measured Western blotting. In vitro , norepinephrine (NE) stimulate hypertrophy. Parameters reactive oxygen species levels, mitochondrial membrane potential, ATP concentration, CK/MB content detected H9c2 cells. Results AEA significantly alleviated Network indicated participation AKT CHF, modulated Praeparata. vivo administration effectively ameliorated performance, evidenced elevation ejection fraction. displayed diminishment collagen fiber. Metabolomics showed that several metabolites tetrahydroxycorticosterone, decylubiquinone taurocholic acid increased TAC serum. Additionally, levels expression Drp1, Opa1, Atg5 altered group. NE stimulation cell surface area deteriorated functions partially reversed results, mechanism associated with mitophagy. Conclusion This study revealed improved function via PI3K/AKT/Bnip3 pathway.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4673 - 4673
Published: May 14, 2025
Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that constantly expanding, with fast-growing prevalence, and it affects about quarter of the world’s population. This condition significant risk factor for cardiovascular, hepatic, oncologic diseases, such as hypertension, hepatoma, atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, acknowledged secondarily related chronic diseases metabolic cardiovascular conditions, liver among other comorbidities associated insulin resistance inflammation, besides inactivity poor nutrition. The physiopathology involving MAFLD sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, seem some keys this relationship since hormone target mainly skeletal muscle. review aimed comprehensively discuss main physiological pathways involved in these conditions. are interconnected by complex network pathophysiological mechanisms, resistance, muscle tissue production capacity, inflammatory state, which contributors relationship. In addition, clinical analysis, patients manifest more severe hepatitis fibrosis when compared only MAFLD. These patients, both disorders, also present improvement their treated sarcopenia, reinforcing association between them. Lifestyle changes accompanied non-pharmacological interventions, dietary therapy increased physical activity, undoubtedly improve scenario.
Language: Английский
Citations
0
Future Oncology, Journal Year: 2024, Volume and Issue: 21(5), P. 593 - 603
Published: Dec. 29, 2024
Breast cancer (BC) is a global women's health concern, with ongoing research to address diagnostic and treatment challenges. Understanding the developmental mechanisms vital for improved clinical prevention strategies. Mitochondria, undergo dynamic processes like fission fusion, regulated by proteins Dynamic-related protein 1 (DRP1). DRP1 plays key role in mitochondrial fission, process associated BC development. This study aims explore impact of on growth, assessing its potential as therapeutic target. The findings could contribute better understanding mitochondria-related molecular development guide identification drug targets.
Language: Английский
Citations
1
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107776 - 107776
Published: Sept. 3, 2024
Language: Английский
Citations
0