Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives DOI Creative Commons

Teresa Glomb,

Joe O. Minta,

Michalina Nowosadko

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6036 - 6036

Published: Dec. 21, 2024

Compounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulating pro-inflammatory cytokine levels, or having effects on other specific enzymes. Some also display activities vivo. In many publications, new 1,2,4-triazole-based exceed those reference drugs, suggesting promising potential therapeutic agents. This review active derivatives with is based literature published from 2015–2024.

Language: Английский

Design and synthesis of novel pyrimidine-pyrazole hybrids with dual anticancer and anti-inflammatory effects targeting BRAFV600E and JNK DOI Creative Commons
Mohammed S. Abdel‐Maksoud, Hebatollah E. Eitah, Rasha M. Hassan

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Two new series of pyrimidinyl ethyl pyrazoles derivatives 13a–f and 14a–f were designed synthesized to possess both anticancer effect by inhibiting BRAFV600E anti-inflammatory JNK isoforms. The structure the compounds was generated from hybridization two main moieties. moiety reported inhibitors, pyrazole isoforms inhibitors. final tested on BRAFV600E, JNK1, JNK2, JNK3 measure their kinases inhibitory effect. Compound 14c showed highest activity with IC 50 = 0.51 μM, 0.53 1.02 0.009 μM JNK3,and respectively. All over four cancer cell lines related target enzymes. 14d most potent all 0.87 0.91, 0.42 0.63 MOLT-4, K-562, SK-MEL-28, A375 lines, ability inhibit MEK1/2 ERK1/2 phosphorylation performed using western blot. cycle analysis compound line revealed that arrested growth at G0-G1 phase. remarkably decreased migration compared control group in traditional test. Compounds significant nitric oxide release PGE2 production raw 264.7 macrophages. 13d 1 4d exhibited high iNOS COX-2 COX-1. Finally, TNF-alpha IL-6 determined. Graphical abstract synthesized. able BRAFV600E. play a key role inflammatory disorders. Final for activities.

Language: Английский

Citations

0
Design and synthesis of novel cyclohexanecarboxamides with anticonvulsant effect by activating Nrf2-ARE pathway DOI
Walaa Hamada Abd‐Allah, Mohammed S. Abdel‐Maksoud, Marawan A. Elbaset

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 159, P. 108357 - 108357

Published: March 10, 2025

Language: Английский

Citations

0
Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives DOI Creative Commons

Teresa Glomb,

Joe O. Minta,

Michalina Nowosadko

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6036 - 6036

Published: Dec. 21, 2024

Compounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulating pro-inflammatory cytokine levels, or having effects on other specific enzymes. Some also display activities vivo. In many publications, new 1,2,4-triazole-based exceed those reference drugs, suggesting promising potential therapeutic agents. This review active derivatives with is based literature published from 2015–2024.

Language: Английский

Citations

1