Chemodynamic Therapy Enhanced 131I‐Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis DOI

Caiting Deng,

Jingjing Zhang, Yuchen Yang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Iodine‐131 ( 131 I), a cornerstone of thyroid cancer therapy, suffers from limited efficacy in other cancers due to poor tumor accumulation and hypoxia‐driven radiotherapy resistance. To overcome these challenges, I‐M@HI, theranostic nanoparticle was engineered that synergizes with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin indocyanine green self‐assembled on albumin, enabling dual‐mode fluorescence/MRI‐guided imaging, tumor/sentinel lymph node‐targeted accumulation, hypoxia modulation. The catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating amplify I radiotherapy. In subcutaneous tumors, I‐M@HI achieved >85% inhibition by inducing immunogenic cell death, marked calreticulin exposure high mobility group box 1 release, triggered systemic anti‐tumor immunity. Strikingly, breast metastasis model, selectively eradicated sentinel node metastases, reducing lung metastatic nodules >90%, representing critical advancement preventing spread. work pioneers multifunctional nanoplatform not only enhances but also redefines precision inhibition, offering transformative strategy advanced therapy.

Language: Английский

Chemodynamic Therapy Enhanced 131I‐Radiotherapy for Efficient Inhibition on Cancer Growth and Metastasis DOI

Caiting Deng,

Jingjing Zhang, Yuchen Yang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Iodine‐131 ( 131 I), a cornerstone of thyroid cancer therapy, suffers from limited efficacy in other cancers due to poor tumor accumulation and hypoxia‐driven radiotherapy resistance. To overcome these challenges, I‐M@HI, theranostic nanoparticle was engineered that synergizes with chemodynamic therapy (CDT). This platform integrated Mn(III) porphyrin indocyanine green self‐assembled on albumin, enabling dual‐mode fluorescence/MRI‐guided imaging, tumor/sentinel lymph node‐targeted accumulation, hypoxia modulation. The catalyzes intratumoral hydrogen peroxide into cytotoxic hydroxyl radicals for CDT while alleviating amplify I radiotherapy. In subcutaneous tumors, I‐M@HI achieved >85% inhibition by inducing immunogenic cell death, marked calreticulin exposure high mobility group box 1 release, triggered systemic anti‐tumor immunity. Strikingly, breast metastasis model, selectively eradicated sentinel node metastases, reducing lung metastatic nodules >90%, representing critical advancement preventing spread. work pioneers multifunctional nanoplatform not only enhances but also redefines precision inhibition, offering transformative strategy advanced therapy.

Language: Английский

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