Aging: a Struggle for Beneficial to Overcome Negative Factors made by Muscle and Bone
Mechanisms of Ageing and Development,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112039 - 112039
Published: Feb. 1, 2025
Language: Английский
TGF-β: elusive target in diabetic kidney disease
Renal Failure,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: April 3, 2025
Transforming
growth
factor-beta
(TGF-β),
a
cytokine
with
near
omnipresence,
is
an
integral
part
of
many
vital
cellular
processes
across
the
human
body.
The
family
includes
three
isoforms:
1,
2,
and
3.
These
cytokines
play
significant
role
in
fibrosis
cascade.
Diabetic
kidney
disease
(DKD),
major
complication
diabetes,
increasing
prevalence
daily,
classical
diagnosis
diabetes
based
on
presence
albuminuria.
occurrence
nonalbuminuric
DKD
has
provided
new
insight
into
pathogenesis
this
disease.
emphasis
multifactorial
pathways
involved
developing
highlighted
some
markers
associated
tissue
fibrosis.
In
diabetic
nephropathy,
TGF-β
significantly
its
pathology.
Its
serum
urine
means
that
it
could
be
diagnostic
tool
while
regulation
provides
potential
therapeutic
targets.
Completely
blocking
signaling
reach
untargeted
regions
cause
unanticipated
effects.
This
paper
reviews
basic
details
as
cytokine,
DKD,
updates
research
carried
out
to
validate
candidacy.
Language: Английский
Recent Stem-Cell-Based and Stem-Cell-Free Possibilities for the Therapeutic Management of the Osteonecrosis of the Jaw
Merita Mazreku,
No information about this author
Ľuboš Danišovič,
No information about this author
Martin Klein
No information about this author
et al.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 595 - 595
Published: April 16, 2025
Osteonecrosis
of
the
jaw
(ONJ),
including
maxilla
and
mandible,
is
considered
a
challenging
therapeutic
problem,
mainly
due
to
lack
understanding
its
pathogenesis.
It
well
known
that
ONJ
severe
side
effect
caused
by
certain
medications
used
treat
bone
metastasis
osteoporosis,
such
as
bisphosphonates,
which
inhibit
resorption.
Other
therapeutics
with
similar
effects
are,
for
instance,
receptor
activators
nuclear
factor
kappa-B
ligand
(RANK-L)
inhibitor
(denosumab),
tyrosine
kinase
inhibitors
(sunitinib),
antiangiogenics
(bevacizumab).
The
conservative
or
surgical
treatment
these
medication-related
osteonecroses
(MRONJs)
generally
effortful
still
not
entirely
effective.
Therefore,
research
seeks
alternative
options
like
tissue
engineering
stem
cell
therapy,
predominantly
represent
mesenchymal
cells
(MSCs)
their
derivatives,
extracellular
vesicles.
Moreover,
it
was
published
novel
therapy
could
even
prevent
onset
MRONJ.
On
other
hand,
administration
may
also
be
accompanied
some
health
risks,
an
increased
chance
cancer
occurrence
in
patients.
current
review
paper
summarizes
most
recent
progress
stem-cell-based
stem-cell-free
ONJ.
Similarly,
we
discuss
this
approach’s
future
perspectives
possible
obstacles.
Language: Английский
Effects of Temperature and Time on the Denaturation of Transforming Growth Factor Beta-1 and Cytokines from Bovine Platelet-Rich Gel Supernatants
Gels,
Journal Year:
2024,
Volume and Issue:
10(9), P. 583 - 583
Published: Sept. 11, 2024
There
is
a
lack
of
information
about
transforming
growth
factor
beta-1
(TGF-β
Language: Английский