New Binary Adducts of Panobinostat with Different Carboxylic Acid Based NSAIDs: Structural Analysis and Physicochemical Properties Investigation DOI Open Access

Gowtham Kenguva,

Smruti Rekha Rout, Ananya Kar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(42)

Published: Nov. 1, 2024

Abstract Adoption of multitarget, cost‐effective fixed‐dose medication combinations can help lower the pill load without increasing risk adverse events. In this study, three new 1:1 drug‐drug binary solid forms panobinostat (PNB) and nonsteroidal anti‐inflammatory drugs (NSAIDs) were effectively synthesized by liquid‐assisted grinding slow evaporation crystallization techniques. The obtained extensively characterized various analytical structural investigation revealed that all molecular adducts formed salt with a comparable (10) graph set pattern created heteromeric interactions between PNB corresponding formers. To determine dissolving behavior newly developed adducts, solubility tests performed at pH levels (pH 1.2 7), results indicated is increased 7.0, particularly PNB.NIF has 0.195 mg/mL, which seven times higher than parent drug. Furthermore, PXRD was used to assess stability adduct varied temperature humidity it found are stable. Based on findings, we hope have possible potential broaden use drug changing chemical structures.

Language: Английский

Structural landscape of new salts of the antihistamine drug bilastine: implications in physicochemical properties and anticancer activity against skin cancer DOI

Manimurugan Kanagavel,

Rajan Marystella Sparjan Samuvel,

Vaikundamoorthy Ramalingam

et al.

CrystEngComm, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Seven new salts of the antihistamine drug bilastine were prepared with inorganic acid counter ions and demonstrated modified solubility & dissolution along study anti-cancer activity against skin cancer.

Language: Английский

Citations

0
New Binary Adducts of Panobinostat with Different Carboxylic Acid Based NSAIDs: Structural Analysis and Physicochemical Properties Investigation DOI Open Access

Gowtham Kenguva,

Smruti Rekha Rout, Ananya Kar

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(42)

Published: Nov. 1, 2024

Abstract Adoption of multitarget, cost‐effective fixed‐dose medication combinations can help lower the pill load without increasing risk adverse events. In this study, three new 1:1 drug‐drug binary solid forms panobinostat (PNB) and nonsteroidal anti‐inflammatory drugs (NSAIDs) were effectively synthesized by liquid‐assisted grinding slow evaporation crystallization techniques. The obtained extensively characterized various analytical structural investigation revealed that all molecular adducts formed salt with a comparable (10) graph set pattern created heteromeric interactions between PNB corresponding formers. To determine dissolving behavior newly developed adducts, solubility tests performed at pH levels (pH 1.2 7), results indicated is increased 7.0, particularly PNB.NIF has 0.195 mg/mL, which seven times higher than parent drug. Furthermore, PXRD was used to assess stability adduct varied temperature humidity it found are stable. Based on findings, we hope have possible potential broaden use drug changing chemical structures.

Language: Английский

Citations

0