Fluorescent probes in autoimmune disease research: current status and future prospects DOI Creative Commons
Junli Chen, Mingkai Chen, Xiaolong Yu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 9, 2025

Autoimmune diseases (AD) present substantial challenges for early diagnosis and precise treatment due to their intricate pathogenesis varied clinical manifestations. While existing diagnostic methods strategies have advanced, sensitivity, specificity, real-time applicability in settings continue exhibit significant limitations. In recent years, fluorescent probes emerged as highly sensitive specific biological imaging tools, demonstrating potential AD research.This review examines the response mechanisms historical evolution of various types probes, systematically summarizing latest research advancements application autoimmune diseases. It highlights key applications biomarker detection, dynamic monitoring immune cell functions, assessment drug efficacy. Furthermore, this article analyzes technical currently encountered probe development proposes directions future research. With ongoing materials science, nanotechnology, bioengineering, are anticipated achieve higher sensitivity enhanced functional integration, thereby facilitating monitoring, innovative Overall, possess scientific significance value both related diseases, signaling a new era personalized precision medicine.

Language: Английский

A potent fluorescent probe for HOCl with dual NIR emissions: achieving the early diagnosis of polystyrene microplastics-induced liver injury involved in ferroptosis DOI
Jianwei Cui,

James T. C. Teng,

Peini Xiang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138087 - 138087

Published: March 1, 2025

Language: Английский

Citations

0
Fluorescent probes in autoimmune disease research: current status and future prospects DOI Creative Commons
Junli Chen, Mingkai Chen, Xiaolong Yu

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 9, 2025

Autoimmune diseases (AD) present substantial challenges for early diagnosis and precise treatment due to their intricate pathogenesis varied clinical manifestations. While existing diagnostic methods strategies have advanced, sensitivity, specificity, real-time applicability in settings continue exhibit significant limitations. In recent years, fluorescent probes emerged as highly sensitive specific biological imaging tools, demonstrating potential AD research.This review examines the response mechanisms historical evolution of various types probes, systematically summarizing latest research advancements application autoimmune diseases. It highlights key applications biomarker detection, dynamic monitoring immune cell functions, assessment drug efficacy. Furthermore, this article analyzes technical currently encountered probe development proposes directions future research. With ongoing materials science, nanotechnology, bioengineering, are anticipated achieve higher sensitivity enhanced functional integration, thereby facilitating monitoring, innovative Overall, possess scientific significance value both related diseases, signaling a new era personalized precision medicine.

Language: Английский

Citations

0