
Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)
Published: April 10, 2025
ABSTRACT In this study, N‐phenylortho‐phenylenediamine and N‐phenyl ethylenediamine were utilized as amines, two novel ligands, benzimidazole (LI) Schiff base (LII), synthesized through condensation reactions with 3‐methoxy‐4‐benzyloxybenzaldehyde. Furthermore, using these same LIII (benzimidazole) 3‐phenoxybenzaldehyde LIV (Schiff base) 4‐benzyloxybenzaldehyde in accordance the literature. Then, Pt (II) complexes (Ia, Ib, II, III, IV) prepared it was determined that Ia Ib are geometric isomers. The ligands characterized 1 H‐NMR, 13 C‐NMR, FT‐IR, elemental analysis methods. cytotoxic effects of evaluated on SH‐SY5Y neuronal cells. Low‐toxicity Ia, IV then tested for their ability to inhibit amyloid beta (Aβ 1–42 ) aggregation. Thioflavin T fluorescence analysis, AFM imaging, MALDI‐TOF mass spectrometry demonstrated complexes, particularly at a 1:1 complex‐to‐amyloid molar ratio, effectively inhibited Aβ These findings suggest containing may be effective against Alzheimer's disease by alleviating toxicity.
Language: Английский