Synthesis and modification of novel thiazole-fused quinoxalines as new insecticidal agents against the cotton leafworm Spodoptera litura: design, characterization, in vivo bio-evaluation, toxicological effectiveness, and study their mode of action
Doaa M. Elsisi,
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Moustafa S. Abusaif,
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Eman El-Said
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et al.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(2), P. 1391 - 1406
Published: Jan. 1, 2025
New
insecticidal
agents
based
on
quinoxaline
derivatives
targeting
the
cotton
leafworm,
Spodoptera
litura
.
Language: Английский
Novel Pyrrolidine-bearing quinoxaline inhibitors of DNA Gyrase, RNA polymerase and spike glycoprotein
Maha A. Ebrahim,
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Triveena M. Ramsis,
No information about this author
Nirvana A. Gohar
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et al.
Bioorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
156, P. 108218 - 108218
Published: Jan. 27, 2025
Language: Английский
Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 21, 2025
This
study
systematically
investigated
the
molecular
mechanisms
underlying
tetrahydrocannabinol
(THC)-induced
hepatotoxicity
in
humans
through
an
integrated
approach
combining
network
toxicology,
docking,
and
experimental
validation.
Our
analysis
identified
22
core
targets
associated
with
THC-mediated
hepatotoxicity.
Protein-protein
interaction
(PPI)
revealed
significant
functional
associations
among
these
potential
target
proteins.
KEGG
pathway
GO
term
analyses
demonstrated
that
THC
potentially
exerts
hepatotoxic
effects
multiple
biological
processes,
including
endocrine
resistance,
bile
secretion,
negative
regulation
of
apoptosis,
cellular
oxidant
detoxification.
Disease
enrichment
further
several
pathological
conditions
closely
THC-induced
hepatic
damage.
Molecular
docking
simulations
strong
binding
affinities
between
domains
17
proteins
participated
aforementioned
enriched
pathways.
An
vitro
model
hepatocyte
injury
was
successfully
established
subsequently
validated
RT-qPCR
experiment.
exposure
significantly
altered
expression
patterns
10
critical
genes:
ERBB2,
GPX1,
MAPK14,
NR1H4,
SOD1,
CXCR2,
PPARG,
EGFR,
TYMS
KDR.
The
appear
to
arise
from
synergistic
interplay
pathways
coordinated
dysfunction
various
gene
products.
These
findings
elucidate
key
therapeutic
hepatotoxicity,
providing
a
theoretical
foundation
for
developing
clinical
interventions
hepatoprotective
strategies
against
cannabis-related
liver
Language: Английский
Discovery of Novel Bicyclic and Tricyclic Cyclohepta[b]thiophene Derivatives as Multipotent AChE and BChE Inhibitors, In-Vivo and In-Vitro Assays, ADMET and Molecular Docking Simulation
European Journal of Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
284, P. 117201 - 117201
Published: Dec. 24, 2024
Language: Английский