The role of fructose-1,6-bisphosphatase 1 on regulating the cancer progression and drug resistance DOI Creative Commons
Mengmeng Wang,

Xiaoju Huang,

Dan Zhang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

Abstract Fructose-1,6-bisphosphatase 1 (FBP1) is the enzyme that limits process of gluconeogenesis as it facilitates hydrolysis fructose-1,6-bisphosphate(F-1,6-BP) to produce fructose-6-phosphate(F6P) and inorganic phosphate. Gluconeogenesis production glucose from small carbohydrate substrates. The gluconeogenic typically suppressed in cancer because inhibits glycolysis. Apart its involvement cellular metabolism, FBP1 also plays a role gene transcription, mRNA translation stability regulation, immune microenvironment tumors. Because multifaceted functions, mechanisms by which involved tumor development are complex. Moreover, deficiency associated with radiation chemotherapy resistance poor prognosis patients. Restoration expression cells expected hold promise for therapy. However, up now few reviews have systematically summarized important functional tumorigenesis molecule compounds restore expression. Therefore, this article addresses question “How does contribute progression, can targeting be potential therapeutic approach?” summarizing effects on progression well mediated drug future clinical applications modulators FBP1.

Language: Английский

The role of fructose-1,6-bisphosphatase 1 on regulating the cancer progression and drug resistance DOI Creative Commons
Mengmeng Wang,

Xiaoju Huang,

Dan Zhang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 18, 2025

Abstract Fructose-1,6-bisphosphatase 1 (FBP1) is the enzyme that limits process of gluconeogenesis as it facilitates hydrolysis fructose-1,6-bisphosphate(F-1,6-BP) to produce fructose-6-phosphate(F6P) and inorganic phosphate. Gluconeogenesis production glucose from small carbohydrate substrates. The gluconeogenic typically suppressed in cancer because inhibits glycolysis. Apart its involvement cellular metabolism, FBP1 also plays a role gene transcription, mRNA translation stability regulation, immune microenvironment tumors. Because multifaceted functions, mechanisms by which involved tumor development are complex. Moreover, deficiency associated with radiation chemotherapy resistance poor prognosis patients. Restoration expression cells expected hold promise for therapy. However, up now few reviews have systematically summarized important functional tumorigenesis molecule compounds restore expression. Therefore, this article addresses question “How does contribute progression, can targeting be potential therapeutic approach?” summarizing effects on progression well mediated drug future clinical applications modulators FBP1.

Language: Английский

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