Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(4), P. 449 - 465

Published: Jan. 31, 2025

The study of chalcone-1,2,3-triazole hybrids for anticancer activity is quite a recent area focus, primarily because the increasing demand developing new drugs to treat cancer. chalcones and 1,2,3-triazole rings in hybrid compounds has recently emerged as promising strategy novel agents. ring, known its stability hydrogen bonding capabilities, enhances target binding affinity these hybrids. Chalcones possess an α,β-unsaturated carbonyl system crucial their synergistic effect two moieties results with potent properties. This review explores structure-activity relationship studies which revealed that electronic lipophilic properties substituents on phenyl significantly influence activity. Electron-donating electron-withdrawing groups can affect cellular uptake engagement. Incorporating various into ring improve selectivity potency against specific cancer cell lines. These often exert effects through apoptosis cycle disruption. Recent research indicates chalcone hold therapeutic promise Further optimization SAR in-depth mechanistic investigations could lead development highly selective agents minimal toxicity.

Language: Английский

Network pharmacology and experimental verification to explore the molecular mechanisms of Astragaloside IV against diabetic encephalopathy

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151778 - 151778

Published: April 1, 2025

Language: Английский