Novel 2,5‐dihydro‐3H‐[1,2,4]triazino[5,6‐b]indole derivatives decorated with disulfide moiety are effective for treating bacterial infections by inducing reactive oxygen species DOI
Guoqing Wang,

Hong‐Wu Liu,

Ya Zhou

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract BACKGROUND Infectious diseases caused by pathogenic bacteria are the main causes of death in humans, and responsible for reduced yield quality quantity plants globally. This underscores need developing bactericide alternatives with novel modes‐of‐action. RESULTS Herein, we devised a series 2,5‐dihydro‐3 H ‐[1,2,4]triazino[5,6‐ b ]indole derivatives decorating disulfide moiety ( W 1 –W 36 ). Bioassay results indicated their antibacterial activity against three [ Xoo Xanthomonas oryzae pv. ), Xac axonopodis citri ) Psa Pseudomonas syringae actinidiae )]. Compound demonstrated eminent anti‐ vitro , median effecgtive concentration (EC 50 value 0.77 μg mL −1 which was considerably higher than that reference agent thiodiazole copper (TC, EC = 104 At 200 compound better vivo control efficiency (46.09% curative activity; 51.26% protective activity) toward rice bacterial blight diseases, >20% increase relative to TC. Mechanistic studies revealed enabled suppression activities oxidoreductases including superoxide dismutase catalase, disrupted redox balance, ultimately induced cell apoptosis. CONCLUSION Overall, these new molecules were characterized high ability, reactive oxygen species targeting performance, low toxicity. They unprecedented potential controlling infection. © 2025 Society Chemical Industry.

Language: Английский

Novel 2,5‐dihydro‐3H‐[1,2,4]triazino[5,6‐b]indole derivatives decorated with disulfide moiety are effective for treating bacterial infections by inducing reactive oxygen species DOI
Guoqing Wang,

Hong‐Wu Liu,

Ya Zhou

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract BACKGROUND Infectious diseases caused by pathogenic bacteria are the main causes of death in humans, and responsible for reduced yield quality quantity plants globally. This underscores need developing bactericide alternatives with novel modes‐of‐action. RESULTS Herein, we devised a series 2,5‐dihydro‐3 H ‐[1,2,4]triazino[5,6‐ b ]indole derivatives decorating disulfide moiety ( W 1 –W 36 ). Bioassay results indicated their antibacterial activity against three [ Xoo Xanthomonas oryzae pv. ), Xac axonopodis citri ) Psa Pseudomonas syringae actinidiae )]. Compound demonstrated eminent anti‐ vitro , median effecgtive concentration (EC 50 value 0.77 μg mL −1 which was considerably higher than that reference agent thiodiazole copper (TC, EC = 104 At 200 compound better vivo control efficiency (46.09% curative activity; 51.26% protective activity) toward rice bacterial blight diseases, >20% increase relative to TC. Mechanistic studies revealed enabled suppression activities oxidoreductases including superoxide dismutase catalase, disrupted redox balance, ultimately induced cell apoptosis. CONCLUSION Overall, these new molecules were characterized high ability, reactive oxygen species targeting performance, low toxicity. They unprecedented potential controlling infection. © 2025 Society Chemical Industry.

Language: Английский

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