Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: June 15, 2021
Mast
cells
(MCs)
are
strategically
located
in
tissues
close
to
the
external
environment,
being
one
of
first
immune
interact
with
invading
pathogens.
They
long
living
effector
equipped
different
receptors
that
allow
microbial
recognition.
Once
activated,
MCs
release
numerous
biologically
active
mediators
site
pathogen
contact,
which
induce
vascular
endothelium
modification,
inflammation
development
and
extracellular
matrix
remodeling.
Efficient
direct
antimicrobial
mechanisms
involve
phagocytosis
oxidative
non-oxidative
destruction,
trap
formation,
substances.
also
contribute
host
defense
through
attraction
activation
phagocytic
inflammatory
cells,
shaping
innate
adaptive
responses.
However,
as
part
their
response
pathogens
under
an
impaired,
sustained,
or
systemic
activation,
may
tissue
damage.
This
review
will
focus
on
current
knowledge
about
indirect
contribution
clearance.
Antimicrobial
addressed
special
attention
signaling
pathways
involved
molecular
weapons
implicated.
The
role
a
dysregulated
can
increase
morbidity
mortality
is
reviewed
discussed,
highlighting
complexity
biology
context
host-pathogen
interactions.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(15), P. 8255 - 8255
Published: July 31, 2021
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
is
the
virus
responsible
for
COVID-19
pandemic.
Patients
may
present
as
asymptomatic
or
demonstrate
mild
to
severe
and
life-threatening
symptoms.
Although
has
a
respiratory
focus,
there
are
major
cardiovascular
complications
(CVCs)
associated
with
infection.
The
reported
CVCs
include
myocarditis,
heart
failure,
arrhythmias,
thromboembolism
blood
pressure
abnormalities.
These
occur,
in
part,
because
of
dysregulation
Renin–Angiotensin–Aldosterone
System
(RAAS)
Kinin–Kallikrein
(KKS).
A
route
by
which
SARS-CoV-2
gains
cellular
entry
via
docking
viral
spike
(S)
protein
membrane-bound
angiotensin
converting
enzyme
(ACE2).
roles
ACE2
within
immune
systems
vital
ensure
homeostasis.
key
routes
development
recently
described
long
COVID
have
been
hypothesised
direct
consequences
S
protein/ACE2
axis,
downregulation
resulting
damage
inflicted
response.
Here,
we
review
impact
on
system,
mechanisms
RAAS
KKS
can
occur
following
infection
future
implications
pharmacological
therapies.
Foods,
Journal Year:
2022,
Volume and Issue:
11(4), P. 571 - 571
Published: Feb. 16, 2022
Population
growth
is
the
driving
change
in
search
for
new,
alternative
sources
of
protein.
Macroalgae
(otherwise
known
as
seaweeds)
do
not
compete
with
other
food
space
and
resources
they
can
be
sustainably
cultivated
without
need
arable
land.
are
significantly
rich
protein
amino
acid
content
compared
to
plant-derived
proteins.
Herein,
physical
chemical
extraction
methods
well
novel
techniques
including
enzyme
hydrolysis,
microwave-assisted
ultrasound
sonication
discussed
strategies
this
resource.
The
generation
high-value,
economically
important
ingredients
such
bioactive
peptides
explored
application
macroalgal
proteins
human
foods
animal
feed.
These
that
have
been
shown
inhibit
enzymes
renin,
angiotensin-I-converting
(ACE-1),
cyclooxygenases
(COX),
α-amylase
α-glucosidase
associated
hypertensive,
diabetic,
inflammation-related
activities
explored.
This
paper
discusses
significant
uses
seaweeds,
which
range
from
utilising
their
anthelmintic
anti-methane
properties
feed
additives,
techno-functional
formulation
ice
creams,
health
beneficial
reduce
high
blood
pressure
prevent
inflammation.
information
was
collated
following
a
review
206
publications
on
use
seaweeds
feeds
processing
extract
seaweed
Journal of Translational Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: June 11, 2022
Conventional
and
unconventional
lipid
parameters
are
associated
with
diabetes
risk,
the
comparative
studies
on
for
predicting
future
however,
still
extremely
limited,
value
of
conventional
in
has
not
been
evaluated.
This
study
was
designed
to
determine
predictive
development
diabetes.The
a
longitudinal
follow-up
15,464
participants
baseline
normoglycemia.
At
baseline,
such
as
low-density
lipoprotein
cholesterol
(LDL-C),
triglyceride
(TG),
total
(TC),
high-density
(HDL-C)
were
measured/calculated,
non-HDL-C,
remnant
(RC),
LDL/HDL-C
ratio,
TG/HDL-C
non-HDL/HDL-C
TC/HDL-C
ratio
RC/HDL-C
calculated.
Hazard
(HR)
95%
confidence
interval
(CI)
estimated
by
Cox
proportional
hazard
regression
adjusting
demographic
diabetes-related
risk
factors.
The
threshold
fluctuation
intervals
evaluated
time-dependent
receiver
operator
characteristics
(ROC)
curve.The
incidence
rate
3.93
per
1000
person-years
during
an
average
period
6.13
years.
In
non-diabetic
population,
only
TG
HDL-C
among
while
all
except
non-HDL-C
significantly
risk.
contrast,
reflected
better
than
parameters,
best
parameter
reflect
(HR:
6.75,
CI
2.40-18.98).
Sensitivity
analysis
further
verified
robustness
this
result.
Also,
ROC
curve
showed
that
RC,
medium-and
long-term
diabetes.Unconventional
generally
outperform
assessing
It
is
suggested
should
also
be
routinely
clinical
practice.
