Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health

Oxidative Medicine and Cellular Longevity, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 19

Published: March 10, 2019

The prevalence of cardiovascular disease (CVD) is increasing over time. CVD a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities have emerged as efficient therapeutics for the treatment CVD. scavenge free radicals, improve glucose tolerance insulin sensitivity, modulate lipid metabolism adipocyte differentiation, suppress inflammation apoptosis, endothelial dysfunction. intake citrus has been associated with improved outcomes. Although exerted multiple beneficial effects, their mechanisms action are not completely established. In this review, we summarized recent findings advances understanding underlying protective effects against oxidative stress, inflammation, diabetes, dyslipidemia, dysfunction, atherosclerosis. Further studies clinical trials assess efficacy explore mechanism(s) recommended.

Language: Английский

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Quercetin and metabolic syndrome: A review

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(10), P. 5352 - 5364

Published: June 8, 2021

Metabolic syndrome (MetS) is a complex of diseases that lead to mortality due the development cardiovascular problems. Quercetin, as an important flavonoid, has various properties such decreasing blood pressure, anti‐hyperlipidemia, anti‐hyperglycemia, anti‐oxidant, antiviral, anticancer, anti‐inflammatory, anti‐microbial, neuroprotective, and cardio‐protective effects. In this review article, we collected original articles from different sources Google Scholar, Medline, Scopus, Pubmed, which related effect quercetin on improvement signs MetS, including elevated glucose level, hyperlipidemia, obesity, pressure. According these data, may also have role in management metabolic disorders via mechanisms increasing adiponectin, leptin, anti‐oxidant activity, reduction insulin resistance, elevation blocking calcium channel. We attempted make some recommendations application patients. However, it needs do further clinical trials more investigations show real value syndrome.

Language: Английский

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Obesity II: Establishing causal links between chemical exposures and obesity

Biochemical Pharmacology, Journal Year: 2022, Volume and Issue: 199, P. 115015 - 115015

Published: April 5, 2022

Language: Английский

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Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 938 - 961

Published: Jan. 1, 2021

In this fast-food era, people depend on ready-made foods and engage in minimal physical activities that ultimately change their food habits. Majorities of such have harmful effects human health due to higher percentages saturated fatty acids, trans-fatty hydrogenated fats the form high lipid diet (HLD). Moreover, manufacturers add monosodium glutamate (MSG) enhance taste palatability HLD. Both MSG HLD induce generation reactive oxygen species (ROS) thereby alter redox-homeostasis cause systemic damage. However, mixed (MH) consumption leads dyslipidemia, silently develops non-alcoholic liver disease followed by metabolic alterations anomalies, even malignancies, via modulating different signaling pathways. This comprehensive review formulates care strategies create global awareness about impact MH body recommends daily more natural rich antioxidants instead toxic ingredients counterbalance MH-induced anomalies.

Language: Английский

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Long-Term Resistance–Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity

Sports, Journal Year: 2023, Volume and Issue: 11(3), P. 54 - 54

Published: Feb. 27, 2023

A sedentary lifestyle and an unhealthy diet increase the risk of obesity. People with obesity experience adipocyte hypertrophy hyperplasia, which increases production proinflammatory cytokines, thereby increasing morbidity mortality. Lifestyle modification using non-pharmacological approaches such as physical exercise prevents increased through its anti-inflammatory effects. The purpose this study was to examine effects different types on decreased cytokines in young adult females total 36 female students from Malang City aged 21.86 ± 1.39 years body mass index (BMI) 30.93 3.51 kg/m2 were recruited followed three interventions: moderate-intensity endurance training (MIET), resistance (MIRT), combined (MICT). performed at a frequency 3x/week for 4 weeks. Statistical analysis Package Social Science (SPSS) version 21.0, paired sample t-test. results revealed that serum IL-6 TNF-α levels significantly between pre-training post-training (MIET, MIRT, MICT) (p ≤ 0.001). percentage change CTRL (0.76 13.58%), MIET (-82.79 8.73%), MIRT (-58.30 18.05%), MICT (-96.91 2.39%), There (6.46 12.13%), (-53.11 20.02%), (-42.59 21.64%), (-73.41 14.50%), All consistently reduced TNF-α.

Language: Английский

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Natural products as safeguards against monosodium glutamate-induced toxicity.

DOAJ (DOAJ: Directory of Open Access Journals), Journal Year: 2020, Volume and Issue: 23(4), P. 416 - 430

Published: April 1, 2020

Monosodium glutamate is a sodium salt of nonessential amino acid, L-glutamic which widely used in food industry. Glutamate plays an important role principal brain functions including formation and stabilization synapses, memory, cognition, learning, as well cellular metabolism. However, ingestion foodstuffs rich monosodium can result the outbreak several health disorders such neurotoxicity, hepatotoxicity, obesity diabetes. The usage medicinal plants their natural products therapy against MSG industry has been suggested to be protective. Calendula officinalis, Curcuma longa, Green Tea, Ginkgo biloba vitamins are some main with protective effect mentioned toxicity through different mechanisms. This review provides summary on effects -induced toxicity.

Language: Английский

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Role of ultra-processed food in fat mass index between 6 and 11 years of age: a cohort study

International Journal of Epidemiology, Journal Year: 2020, Volume and Issue: 50(1), P. 256 - 265

Published: July 17, 2020

Abstract Background Ultra-processed food consumption and obesity have been highlighted as an important relationship to public health. We aimed evaluate the association between ultra-processed body fat from 6 11 years of age. Methods assessed (from frequency questionnaires) (measured by air displacement plethysmography) age among participants Pelotas-Brazil 2004 Birth Cohort. The NOVA classification was used classify foods according processing degree. Body evaluated relative height using mass index (FMI). Generalized estimating equations were answer main research question mediation analyses run assess direct indirect effect in fat. Results At fully adjusted analysis, increase 100 g contribution daily intake at associated with a gain 0.14 kg/m² FMI same period; 58% total (in grams) over change mediated its calorie content. Conclusions childhood early adolescence, this not just due on

Language: Английский

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A metagenome-wide association study of gut microbiome and visceral fat accumulation

Computational and Structural Biotechnology Journal, Journal Year: 2020, Volume and Issue: 18, P. 2596 - 2609

Published: Jan. 1, 2020

Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome visceral fat.We recruited 32 obese adults 30 healthy controls at baseline. Among subjects, 14 subjects underwent laparoscopic sleeve gastrectomy (LSG) were followed 6 months after surgery. Abdominal area (VFA) subcutaneous (SFA) measured by magnetic resonance imaging. Waist, hipline, waist-to-hip ratio (WHR) body mass index (BMI) included as simple parameters. Gut was analyzed metagenomic sequencing.Among parameters, VFA had largest number of correlations with species that differentially enriched following waist, WHR, BMI, SFA. Within negatively correlated VFA, Eubacterium eligens strongest correlation, Clostridium citroniae, C. symbiosum, Bacteroides uniformis, E. ventriosum, Ruminococcaceae bacterium D16, hathewayi, etc. hathewayi citroniae increased LSG. Functional analyses showed among all correlation coefficients obesity-related microbial pathways. Microbial pathways involved in carbohydrate fermentation biosynthesis L-glutamate L-glutamine might contribute accumulation.Visceral more closely compared fat, suggesting intrinsic connection diseases. Specific which associated accumulation new targeted therapies disorders.

Language: Английский

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The interplay between monosodium glutamate (MSG) consumption and metabolic disorders

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19675 - e19675

Published: Sept. 1, 2023

Monosodium glutamate (MSG) is one of the most popular food additives in world and often ingested with commercially processed foods. It can be described as a sodium salt glutamic acid IUPAC name - Sodium 2-aminopentanedioate ionized by water to produce free ions acid. MSG use has significantly increased over past 30 years, its global demand stands huge at three million metric tons which worth $4.5 billion. Asia was responsible for more than quarter consumption country China also leading well production export other countries. Prior year 2020, almost four percent each highest significant increase predicted rise Thailand, Indonesia, Vietnam China, followed Brazil Nigeria. However, several researches featured this review identified major contributor development progression some metabolic disorders such obesity, risk factor syndromes like hypertension, diabetes mellitus cancer initiation. The mechanism induce obesity involves induction hypothalamic lesion, hyperlipidemia, oxidative stress, leptin resistance expression peroxisome proliferator-activated receptors (PPARs) Gamma Alpha. Similarly mellitus, resulted decreased pancreatic beta cell mass, stress rates, reduced glucose insulin transport adipose tissue skeletal muscles, insensitivity, induced severe hyperinsulinemia. Dietary salt, an active component found high blood pressure (which may lead hypertension). used enhance taste tobacco, causing smokers consume product excess thereby increasing development. Depending on amount consumed, both positive negative effects. Despite controversy surrounding MSG's safety probable contribution disorders, still very high. Therefore, article will sensitize public need cautious foods aid regulatory agencies further daily limit based toxicities observed varied dosages reported review.

Language: Английский

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High-fat diet-induced obesity and impairment of brain neurotransmitter pool

Translational Neuroscience, Journal Year: 2020, Volume and Issue: 11(1), P. 147 - 160

Published: Jan. 1, 2020

Abstract Obesity and the brain are linked since can control weight of body through its neurotransmitters. The aim present study was to investigate effect high-fat diet (HFD)-induced obesity on functioning measurement glutamate, dopamine, serotonin metabolic pools. In study, two groups rats served as subjects. Group 1 fed a normal named lean group. 2 an HFD for 4 weeks obese Markers oxidative stress (malondialdehyde, glutathione, glutathione- s -transferase, vitamin C), inflammatory cytokines (interleukin [IL]-6 IL-12), leptin along with lipid profile (cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein levels) were measured in serum. Neurotransmitters serotonin, glutamate tissue. Fecal samples collected observing changes gut flora. tissue, significantly high levels dopamine well low found group compared those ( P > 0.001) discussed relation biochemical It also noted that affected bacterial composition comparison gram-positive cocci dominance obese. results confirm is inflammation, stress, dyslipidemic processes, altered neurotransmitter cause obesity-related neuropsychiatric complications.

Language: Английский

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