Molecules,
Journal Year:
2023,
Volume and Issue:
28(14), P. 5357 - 5357
Published: July 12, 2023
Being
overweight
or
obese
can
predispose
people
to
chronic
diseases
and
metabolic
disorders
such
as
cardiovascular
illnesses,
diabetes,
Alzheimer’s
disease,
cancer,
which
are
costly
public
health
problems
leading
causes
of
mortality
worldwide.
Many
hope
solve
this
problem
by
using
food
supplements,
they
be
self-prescribed,
contain
molecules
natural
origin
considered
incapable
causing
damage
health,
the
only
sacrifice
require
is
economic.
The
market
offers
supplements
containing
plant-derived
(e.g.,
primary
secondary
metabolites,
vitamins,
fibers),
microbes
(probiotics),
microbial-derived
fractions
(postbiotics).
They
control
lipid
carbohydrate
metabolism,
reduce
appetite
(interacting
with
central
nervous
system)
adipogenesis,
influence
intestinal
microbiota
activity,
increase
energy
expenditure.
Unfortunately,
copious
choice
products
different
legislation
on
worldwide
confuse
consumers.
This
review
summarizes
activity
toxicity
dietary
for
weight
clarify
their
potentiality
adverse
reactions.
A
lack
research
regarding
commercially
available
has
been
noted.
Supplements
postbiotic
moieties
particular
interest.
easier
store
transport
safe
even
a
deficient
immune
system.
Health Science Reports,
Journal Year:
2024,
Volume and Issue:
7(2)
Published: Feb. 1, 2024
Abstract
Background
and
Aims
Overweight
obesity
have
become
global
health
challenges
with
increasing
prevalence.
Several
drugs
received
Food
Drug
Administration
approval
for
nonsyndromic
treatment,
but
most
limitations,
including
gastrointestinal
side
effects
limited
weight
loss
efficacy.
Body
Retatrutide,
a
novel
incretin
mimetic
agent,
has
shown
promise
in
clinical
trials
significant
reduction.
It
demonstrated
dosage‐dependent
pharmacokinetics
favorable
safety
profiles.
The
primary
focus
of
this
paper
is
to
explore
retatrutide
critically
assess
its
justify
use
feasibility
while
highlighting
shortcomings.
This
also
delves
into
the
subject
manifestations.
Conclusion
expected
that
retatrutide,
triple
agonist,
will
result
among
individuals
who
are
obese
or
overweight.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(6)
Published: June 24, 2024
Abstract
Diabetic
kidney
disease,
known
as
a
glomerular
arises
from
metabolic
disorder
impairing
renal
cell
function.
Mitochondria,
crucial
organelles,
play
key
role
in
substance
metabolism
via
oxidative
phosphorylation
to
generate
ATP.
Cells
undergo
reprogramming
compensatory
mechanism
fulfill
energy
needs
for
survival
and
growth,
attracting
scholarly
attention
recent
years.
Studies
indicate
that
mitochondrial
significantly
influences
the
pathophysiological
progression
of
DKD.
Alterations
lead
abnormal
expression
signaling
molecules
activation
pathways,
inducing
stress-related
cellular
damage,
inflammatory
responses,
apoptosis,
autophagy
irregularities,
culminating
fibrosis
insufficiency.
This
review
delves
into
impact
on
DKD
pathogenesis,
emphasizing
regulation
regulators
downstream
pathways.
Therapeutic
interventions
targeting
can
potentially
delay
progression.
The
findings
underscore
importance
focusing
develop
safer
more
effective
therapeutic
approaches.
Current Diabetes Reports,
Journal Year:
2023,
Volume and Issue:
23(7), P. 165 - 171
Published: May 6, 2023
Abstract
Purpose
of
Review
To
synthesize
the
existing
literature
regarding
complex
interplay
between
sleep
disturbance,
obesity,
and
diabetes.
The
review
emphasizes
three
pillars
health
being
diet,
exercise,
sleep,
with
notion
that
if
one
is
ignored,
then
other
two
could
suffer.
Recent
Findings
Sleep
deprivation
associated
incident
perhaps
mediated
by
dysregulation
in
leptin
ghrelin
—
hormones
important
regulation
appetite.
apnea
very
common
particularly
among
obese
people
type
2
diabetes
mellitus.
Treatment
has
clear
symptomatic
benefits
although
its
impact
on
long-term
cardiometabolic
less
clear.
Summary
disturbance
may
be
an
modifiable
risk
for
patients
at
disease.
An
assessment
component
comprehensive
care
obesity
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 1, 2023
Obesity
and
diabetes
are
closely
related
metabolic
disorders
that
have
become
major
public
health
concerns
worldwide.
Over
the
past
few
decades,
numerous
studies
explored
underlying
mechanisms
of
these
identified
various
risk
factors,
including
genetics,
lifestyle,
dietary
habits.
Traditional
Chinese
Medicine
(TCM)
has
been
increasingly
recognized
for
its
potential
to
manage
obesity
diabetes.
Weight
loss
is
difficult
sustain,
several
diabetic
therapies,
such
as
sulfonylureas,
thiazolidinediones,
insulin,
might
make
it
harder
lose
weight.
While
lifestyle
changes
should
be
primary
approach
people
interested
in
lowering
weight,
drugs
also
worth
investigating.
Since
some
newer
glucose-lowering
medications
cause
weight
loss,
glucagon-like
peptide-1
receptor
agonists
(GLP-1
RAs)
sodium-glucose
cotransporter
2
inhibitors
(SGLT2i),
additionally
utilized
or
under
consideration
use
anti-obesity
drugs,
frontier
between
medication
appears
shifting.
This
review
provides
an
overview
literature
on
prospect
TCM
their
management.
We
discuss
interventions,
acupuncture,
herbal
medicine,
therapy,
effects
health.
highlight
regulating
gut
microbiota,
reducing
inflammation,
improving
insulin
sensitivity.
The
findings
suggest
may
provide
a
promising
preventing
managing
However,
further
well-designed
needed
confirm
efficacy
safety
interventions
elucidate
action.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
200, P. 107058 - 107058
Published: Jan. 11, 2024
Cardiovascular
disease
(CVD)
remains
the
leading
cause
of
death
and
disability
worldwide.
While
many
factors
can
contribute
to
CVD,
atherosclerosis
is
cardinal
underlying
pathology,
its
development
associated
with
several
metabolic
risk
including
dyslipidemia
obesity.
Recent
studies
have
definitively
demonstrated
a
link
between
low-grade
systemic
inflammation
two
relevant
abnormalities:
hypercholesterolemia
Interestingly,
both
disorders
are
also
endothelial
dysfunction/activation,
proinflammatory
prothrombotic
phenotype
endothelium
that
involves
leukocyte
infiltration
into
arterial
wall,
one
earliest
stages
atherogenesis.
This
article
reviews
current
literature
on
intricate
relationship
obesity
dysfunction,
discusses
effectiveness
present,
emerging
in-development
pharmacological
therapies
used
treat
these
focus
their
effects
inflammatory
state
cardiovascular
risk.
The Journal of Headache and Pain,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Feb. 12, 2024
Migraine
is
a
disabling
neurovascular
disorder
among
people
of
all
ages,
with
the
highest
prevalence
in
fertile
years,
and
women.
impacts
quality
life
affected
individuals
tremendously
and,
addition,
it
associated
highly
prevalent
metabolic
diseases,
such
as
obesity,
diabetes
mellitus
thyroid
dysfunction.
Also,
clinical
response
to
drugs
might
be
patients
disease
due
body
composition
change.
Therefore,
efficacy
antimigraine
could
altered
both
migraine
disease.
However,
knowledge
pharmacology
related
effects
are
limited.
given
relevance,
this
article
provides
comprehensive
overview
current
research
hypotheses
influence
state
on
action
drugs.
In
functioning
vice
versa,
diseases
its
hormonal
modulating
medication
activity
outlined.
Future
exploration
personalizing
treatment
individual
characteristics
necessary
enhance
therapeutic
strategies,
especially
increasing
significance
recent
decades.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(1), P. 212 - 212
Published: Jan. 4, 2022
Drugs
and
food
interact
mutually:
drugs
may
affect
the
nutritional
status
of
body,
acting
on
senses,
appetite,
resting
energy
expenditure,
intake;
conversely,
or
one
its
components
bioavailability
half-life,
circulating
plasma
concentrations
resulting
in
an
increased
risk
toxicity
adverse
effects,
therapeutic
failure.
Therefore,
knowledge
these
possible
interactions
is
fundamental
for
implementation
a
treatment
presence
pharmacological
therapy.
This
case
chronic
kidney
disease
(CKD),
which
medication
burden
could
be
problem,
therapy
plays
important
role
patient's
treatment.
The
aim
this
paper
was
to
review
that
take
place
between
foods
can
potentially
used
renal
patients,
changes
induced
by
drugs.
A
proper
definition
amount
food/nutrient
intake,
adequate
timing
meal
consumption,
adjustment
drug
dosing
schedule
avoid
interactions,
safeguarding
quality
life
patients
guaranteeing
effectiveness
Hence,
close
collaboration
nephrologist,
dietitian,
patient
crucial.
Dietitians
should
consider
with
status,
order
provide
dietary
suggestions,
allow
maximum
safety
therapy,
while
preserving/correcting
status.
