Lycopene Modulates Oxidative Stress and Inflammation in Hypercholesterolemic Rats DOI Creative Commons
Tarfa Albrahim

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(11), P. 1420 - 1420

Published: Nov. 17, 2022

The complicated disorder of hypercholesterolemia has several underlying factors, including genetic and lifestyle factors. Low LDL cholesterol elevated serum total are its defining features. A carotenoid with antioxidant quality is lycopene. Examining lycopene activity in an animal model induced using food was the aim this investigation. Triglycerides, cholesterol, HDL plasma were all measured. Biomarkers renal cardiac function also examined. Apoptotic indicators, pro-inflammatory markers, oxidative stress assessed. Additionally, mRNA expression paraoxonase 1 (PON-1), peroxisome proliferator-activated receptor gamma (PPAR-γ), PPAR-γ coactivator alpha (PGC-1α) tissues Rats showed lipid levels, dysfunction, significant stress, apoptotic markers at end study. Treatment significantly corrected restored these changes. markedly increased PGC-1α PON-1, decreased expression. It determined that capacity to modulate PON-1 signaling pathway order preserve cellular energy metabolism heart kidney, which turn reduces tissue inflammatory response apoptosis. According findings, may be utilized as a medication treat hypercholesterolemia. However, further studies should conducted first determine appropriate dose any adverse effects appear after usage humans.

Language: Английский

Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system DOI Creative Commons
Yu Wang, Zhihui Liu, Jun Ma

et al.

Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102494 - 102494

Published: Sept. 28, 2022

Lycopene (LYC) is a carotenoid, has antioxidant properties. This study investigated whether lycopene attenuates aristolochic acids (AAs) -induced chronic kidney disease. In this experiment, was used to intervene C57BL/6 mice with renal injury induced by acid exposure. The histomorphological changes and serological parameters of the were measured in order assess alleviating effect on nephropathy. vitro vivo experiments carried out verify main mechanism action drug targets improving nephropathy (AAN) various experimental methods such as ELISA, immunohistochemistry, immunofluorescence, Western-blot qRT-PCR. results showed that oxidative stress after AAI exposure, resulting inflammatory response tubular epithelial cell apoptosis. Nrf2/HO-1 signaling pathway inhibited induces kidney, which ultimately leads inflammation After LYC intervened body, it activated Nrf2 nuclear translocation its downstream HO-1 NQO1 pathways. ROS production cells, alleviated mitochondrial damage. further modulated TNF-α/NF-κB cascade, thereby reduced accumulation factors interstitium. Moreover, able up-regulate expression Bcl-2, down-regulate Bax inhibit activation cleaved forms Caspase-9 Caspase-3, finally attenuated apoptosis It concluded activate maintain homeostasis These suggested can be relieve AAN.

Language: Английский

Citations

57
The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism DOI Open Access
Chindiana Khutami, Sri Adi Sumiwi, Nur Kusaira Khairul Ikram

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(4), P. 2056 - 2056

Published: Feb. 12, 2022

Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, treatment requires many drugs. Antioxidant compounds have been reported activities against obesity, diabetes via several mechanisms. This review aims discuss antioxidant activity together with their molecular signaling mechanism. The literature discussed in this was obtained from PUBMED database. Based on collection obtained, having (obesity, diabetes) were identified. supported by various pathways are influenced these compounds, further study which would be useful predicting drug targets for more optimal effect. provides insights utilizing one opposed It hoped future, number drugs treating altogether minimized consequently reducing side effects.

Language: Английский

Citations

56
Protective effects of lycopene on TiO2 nanoparticle‐induced damage in the liver of mice DOI
Hongmei Chang,

Li Li,

Yaxin Deng

et al.

Journal of Applied Toxicology, Journal Year: 2023, Volume and Issue: 43(6), P. 913 - 928

Published: Jan. 12, 2023

Titanium dioxide nanoparticles (nano-TiO2 ) is one of the most widely used and produced nanomaterials. Studies have demonstrated that nano-TiO2 could induce hepatotoxicity through oxidative stress, lycopene has strong antioxidant capacity. The present study aimed to explore if protects liver mice from damage. Ninety-six ICR were randomly divided into eight groups. They control group, -treated group (50 mg/kg BW), lycopene-treated groups (5, 20, 40 50 BW - lycopene-co-treated + 5 lycopene, 20 lycopene). After treated by gavage for 30 days, histopathology was observed. Liver function evaluated using changes in serum biochemical indicators (AST, ALT, ALP); level ROS indirectly reflected SOD, GSH-Px, MDA, GSH, T-AOC. TUNEL assay performed examine apoptosis hepatocytes. Proteins p53, cleaved-caspase 9, 3, Bcl-2, Bax as well p38 detected. Results showed alleviated pathological damage reduced injury induced , decreased -induced ROS. Meanwhile, mitigated resulting accompanied reversed expression apoptosis-related proteins. Furthermore, significantly upregulation p-p38 . In conclusion, this resulted hepatocyte ROS/ROS-p38 MAPK pathway led injury. Lycopene protected against property.

Language: Английский

Citations

36
Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview DOI Creative Commons
Tabussam Tufail,

Huma Bader Ul Ain,

Sana Noreen

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 8715 - 8741

Published: Oct. 16, 2024

Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.

Language: Английский

Citations

15
Lycopene: A Potent Antioxidant with Multiple Health Benefits DOI Creative Commons
Mercy Omoye Shafe,

Nontobeko Myllet Gumede,

Trevor Tapiwa Nyakudya

et al.

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Language: Английский

Citations

13
E Se tea extract ameliorates CCl4 induced liver fibrosis via regulating Nrf2/NF-κB/TGF-β1/Smad pathway DOI
Zhengxuan Wang,

Pengzhen Sun,

Tianrui Zhao

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 115, P. 154854 - 154854

Published: May 4, 2023

Language: Английский

Citations

21
Pharmacological potentials of lycopene against aging and aging‐related disorders: A review DOI Creative Commons
Mehedy Hasan Abir, A.G.M.Sofi Uddin Mahamud, Sadia Haque Tonny

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 11(10), P. 5701 - 5735

Published: June 27, 2023

Aging and aging-related chronic disorders are one of the principal causes death worldwide. The prevalence these is increasing gradually globally. Considering this unwavering acceleration global burden, seeking alternatives to traditional medication prevent risk aging needed. Among them, lycopene, a carotenoid, abundant in many fruits vegetables, including tomatoes, grapefruits, watermelons, it has unique chemical structure be potent antioxidant compound. This nutraceutical also possesses several anti-aging actions, combating biomarkers ameliorating disorders. However, no systematic evaluation yet been carried out that can comprehensively elucidate effectiveness lycopene halting course emergence diseases linked aging. review, therefore, incorporates previous pre-clinical, clinical, epidemiological studies on understand its potency treating role as mimic caloric restriction. Lycopene-rich foods found or attenuate various research. Based evidence, review suggests clinical application improve human health alleviate

Language: Английский

Citations

17
Can Nutraceuticals Support the Treatment of MASLD/MASH, and thus Affect the Process of Liver Fibrosis? DOI Open Access
Aneta Sokal, Sara Jarmakiewicz-Czaja, Katarzyna Ferenc

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5238 - 5238

Published: May 11, 2024

Currently, metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) are considered to be the main causes of fibrosis. In turn, fibrosis may lead development hepatocellular carcinoma or advanced cirrhosis, i.e., potentially life-threatening conditions. It is likely that therapy aimed at reducing risk developing hepatic steatosis inflammation could helpful in minimizing threat/probability organ recent years, increasing attention has been paid influence nutraceuticals prevention treatment diseases. Therefore, aim this review was describe precise role selected ingredients such as vitamin C, beta-carotene, omega-3 fatty acids, curcumin. use these patients with MASLD/MASH, along behavioral pharmacological therapy, have a beneficial effect on combating inflammation, oxidative stress, thereby preventing damage.

Language: Английский

Citations

7
Physicochemical properties, mechanism of action of lycopene and its application in poultry and ruminant production DOI Creative Commons
Yong Long, Siwaporn Paengkoum, Shengyong Lu

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: March 18, 2024

Lycopene is a kind of natural carotenoid that could achieve antioxidant, anti-cancer, lipid-lowering and immune-improving effects by up-regulating or down-regulating genes related to immunity. Furthermore, lycopene natural, pollution-free, has no toxic side effects. The application in animal production shown it improve livestock performance, slaughter immunity, antioxidant capacity, intestinal health, meat quality. Therefore, as new type feed additive, broader prospects many antibiotic-forbidden environments. This article serves reference for the use health additive going over its physical chemical characteristics, lipid-lowering, production.

Language: Английский

Citations

6
Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-κB/Nrf2 DOI
Ali‐Mohammad Rousta, Seyed‐Mohamad‐Sadegh Mirahmadi, Alireza Shahmohammadi

et al.

Drug Research, Journal Year: 2022, Volume and Issue: 72(05), P. 245 - 254

Published: March 31, 2022

Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of failure (ALF) in some countries including United States and with few available treatments. Isorhamnetin a bioflavonoid that found medicinal plants like Hippophae rhamnoides L. Ginkgo biloba promising potential to regulate inflammatory responses. In this study, we evaluated possible effect isorhamnetin prevention APAP-induced ALI analyzed further involvement oxidative stress inflammation-associated factors. Male C57BL/6 mice were given (25 or 100 mg/kg b.w., p.o.) three times at 48, 24, 1 h before APAP administration (300 i.p.). Functional indicators measured as well analysis stress- indices histopathology was also conducted. higher dose significantly lowered serum levels ALT, ALP, AST addition reduction ROS, TBARS, IL-6, TNFα, NF-kB, NLRP3, caspase 1, MPO prevented GSH, SOD activity, sirtuin Nrf2. Additionally, alleviated pathological changes tissue suitably reversed NF-kB Nrf2 immunoreactivity. These findings show protective against acetaminophen-induced through reducing stress, inflammation, pyroptosis which attributed its regulation Nrf2, 1.

Language: Английский

Citations

25