A Possible Synergistic Herbal Solution for COVID-19 DOI Creative Commons

Ephraim Shmaya Lansky

Frontiers in Bioscience-Scholar, Journal Year: 2022, Volume and Issue: 14(2), P. 12 - 12

Published: May 6, 2022

The COVID-19 pandemic has provided an opportunity for repurposing of drugs, including complex, natural to meet the global need safe and effective antiviral medicines which do not promote multidrug resistance nor inflate medical costs. author herein describes his own herbal tinctures, previously prepared oncology, into a possibly synergistic, anti-COVID 41 "herb" formula extracts derived from 36 different plants medicinal mushrooms. A method multi-sample in vitro testing green monkey kidney vero cells is proposed Hypothesis that even such large combination, potency may be preserved, along with therapeutic synergy, smoothness, complexity. possibility formula's improve age considered, suitable it. Collaborative research inquiries are welcome.

Language: Английский

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review DOI Creative Commons

Hadi Al-Jamal,

Sara Idriss,

Rabih Roufayel

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 320 - 320

Published: Feb. 20, 2024

In 2020, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) challenged the world with a global outbreak that led to millions of deaths worldwide. Coronavirus disease 2019 (COVID-19) is symptomatic manifestation this virus, which can range from flu-like symptoms utter clinical complications and even death. Since there was no clear medicine could tackle infection or lower its minimal adverse effects on patients’ health, health organization (WHO) developed awareness programs rate limit fast spread virus. Although vaccines have been as preventative tools, people still prefer going back traditional herbal medicine, provides remarkable benefits either prevent viral progression through different mechanistic pathways relatively insignificant side effects. This comprehensive review scientific evidence elucidating effect 10 plants against SARS-CoV-2, paving way for further studies reconsider plant-based extracts, rich in bioactive compounds, into more advanced assessments order identify their impact patients suffering COVID-19.

Language: Английский

Citations

4
Introduction to cinnamon: production, processing, and functional properties DOI

Mohamed Fawzy Ramadan,

Mohamed A. Farag

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 1, 2025

Language: Английский

Citations

0
An overview on medicinal plants used for combating coronavirus: Current potentials and challenges DOI Creative Commons
Doha H. Abou Baker,

Emad M. Hassan,

Souad El Gengaihi

et al.

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 13, P. 100632 - 100632

Published: May 20, 2023

Worldwide, Severe acute respiratory syndrome Coronavirus (SARS-CoV-2) pandemic crisis, causing many morbidities, mortality, and devastating impact on economies, so the current outbreak of CoV-2 is a major concern for global health. The infection spread quickly caused chaos in countries around world. slow discovery limited treatment options are among main challenges. Therefore, development drug that safe effective against urgently needed. present overview briefly summarizes targets ex: RNA-dependent RNA polymerase (RdRp), papain-like protease (PLpro), 3-chymotrypsin-like (3CLpro), transmembrane serine enzymes (TMPRSS2), angiotensin-converting enzyme 2 (ACE2), structural protein (N, S, E, M), virulence factors (NSP1, ORF7a, NSP3c) which design perspective can be considered. In addition, summarize all anti-COVID-19 medicinal plants phytocompounds their mechanisms action to used as guide further studies.

Language: Английский

Citations

10
The potential role of essential oils in boosting immunity and easing COVID-19 symptoms DOI Creative Commons
Vivek P. Chavda, Pankti C. Balar,

Gargi Jogi

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 5(1), P. 200135 - 200135

Published: March 1, 2024

Several trials have been conducted since the beginning of COVID-19 pandemic because SARS-CoV-2 to establish possible clinical treatments for critical COVID-19-infected individuals. However, many these approaches failed demonstrate positive results in human trials. In middle this investigation, essential oils attracted interest due their numerous benefits and role management illness. Essential virucidal effects at nontoxic quantities tiny molecular size, high lipophilicity, quick commencement action. Furthermore, pulmonary exhalation, lower respiratory tropism, deep lung transport properties increase potential medicinal usefulness. Additionally, popularity as supplementary or preventative agents is influenced by low first-pass metabolism, simplicity formulation, affordability. To evaluate efficacy oil Following Preferred Reporting Items Systematic Review Meta-Analysis (PRISMA) guidelines, studies published English up January 2024 were searched PubMed, Scifinder, Scopus database, using relevant keywords. Those non-English articles, abstracts, conference papers, book chapters, reviews excluded. A total 108 potentially articles included full-text review. manuscript, emphasize on scrutinizing probable antiviral action inhibit replication viruses tried provide an opinion based different performed same concept corners world. Various hold a great work adjuvant therapy prevention COVID-19.

Language: Английский

Citations

3
Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trial DOI
Ramtin Hajibeygi, Sayid Mahdi Mirghazanfari, Naseh Pahlavani

et al.

European Journal of Integrative Medicine, Journal Year: 2022, Volume and Issue: 55, P. 102179 - 102179

Published: Aug. 20, 2022

Language: Английский

Citations

15
Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses DOI Creative Commons
Agieshkumar Balakrishna Pillai, Aashika Raagavi JeanPierre, Vignesh Mariappan

et al.

Cell Stress and Chaperones, Journal Year: 2022, Volume and Issue: 27(3), P. 189 - 195

Published: April 3, 2022

Language: Английский

Citations

14
Strategies for the Management of Spike Protein-Related Pathology DOI Creative Commons
Matthew Halma,

Christof Plothe,

Paul E. Marik

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(5), P. 1308 - 1308

Published: May 17, 2023

In the wake of COVID-19 crisis, a need has arisen to prevent and treat two related conditions, vaccine injury long COVID-19, both which can trace at least part their aetiology spike protein, cause harm through several mechanisms. One significant mechanism is vascular, it mediated by common element illness, receiving vaccine. Given number people experiencing these imperative develop treatment protocols, as well consider diversity injury. This review summarizes known options for injury, mechanisms, evidentiary basis.

Language: Английский

Citations

9
Development of a functional cake with probiotics and micro-encapsulated essential oils: Evaluation of nutritional properties, liver protection, and immune boosting DOI Creative Commons
Manal M. Ramadan,

Eman F. El Haggar,

Rasha S. Mohamed

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e22918 - e22918

Published: Dec. 3, 2023

This study used probiotics and micro-encapsulated clove cinnamon oils to develop a functional cream-stuffed cake based on sweet potatoes flour rice instead of wheat flour. The was evaluated for its physical, chemical, sensory properties antioxidant capacity. protective effect the against liver injury immunosuppression induced by thioacetamide injection in male rats also evaluated. found that eugenol cinnamaldehyde were majority volatile compounds essential cake, with values 78.73 % 81.57 %, respectively, as determined GC-MS analysis. viable counts added ranged from 13.15 11.21 log CFU/g still above threshold health benefits. had an increased dietary fiber protein content while containing low-fat percentage compared commercial sample. innovative contained higher levels water-soluble fat-soluble vitamins minerals such iron, calcium, potassium, zinc. capacity evaluated, it contain 1827.23 mg GAE/100 g total phenols 97.13 QE/100 flavonoids. have activity effective protecting oxidative stress inflammation reducing immunodeficiency associated damage.

Language: Английский

Citations

8
DNA barcoding of herbal supplements on the US commercial market associated with the purported treatment of COVID‐19 DOI

Calin M. Harris,

Diane Y. Kim, C. Jordan

et al.

Phytochemical Analysis, Journal Year: 2024, Volume and Issue: 35(4), P. 664 - 677

Published: Jan. 15, 2024

Abstract Introduction The COVID‐19 pandemic was associated with an increased global use of traditional medicines, including Ayurvedic herbal preparations. Due to their growing demand, processed nature, and the complexity supply chain, there is risk adulteration in these products. Objectives objective this study assess DNA barcoding for species identification supplements on US market treatment respiratory symptoms. Methods A total 54 commercial products containing herbs were tested four regions (i.e., rbcL , matK ITS2, mini‐ITS2) using two composite samples per product. Nine categories targeted: amla, ashwagandha, cinnamon, ginger, guduchi, tribulus, tulsi, turmeric, vacha. Results At least one identified 64.8% expected detected 38.9% Undeclared plant species, other herbs, rice, pepper, 19 products, fungal 12 presence undeclared may be a result intentional substitution or contamination during harvest processing, while likely material environment. greatest sequencing success (42.6–46.3%) obtained primers. Conclusion results indicate that combination genetic loci should used supplements. limitations future research incorporate chemical characterization techniques.

Language: Английский

Citations

2
Effectiveness of Fortified Garlic Extract Oral Capsules as Adjuvant Therapy in Hospitalized Patients with Coronavirus Disease 2019: A Triple-Blind Randomized Controlled Clinical Trial DOI Creative Commons
Mohammad Reza Taghavi, Taraneh Tavanaei Tamanaei, Mohammad Bagher Oghazian

et al.

Current Therapeutic Research, Journal Year: 2023, Volume and Issue: 98, P. 100699 - 100699

Published: Jan. 1, 2023

Herbal medicines have been extensively used to treat coronavirus disease 2019 (COVID-19). Garlic, known exert antiviral and anti-inflammatory effects, can be coadministered with standard treatments combat COVID-19.The aim of the study was evaluate efficacy safety profile Gallecina oral capsules (Samisaz Pharmaceutical Company, Mashhad, Iran), a fortified garlic extract, as adjunctive therapy improve clinical status symptoms in noncritically ill patients hospitalized for COVID-19.This triple-blind randomized, placebo-controlled trial conducted on COVID-19 nonintensive care wards Imam Hassan Hospital. Patients received remdesivir plus 90 mg capsule or placebo every 8 hours 5 days until discharge. The status, respiratory symptoms, laboratory parameters were recorded during period.Patients enrolled between April 24 July 18, 2021. Data from 72 group 69 analyzed. Oxygen saturation, C-reactive protein levels, distribution distress cough similar groups day Although body temperature significantly lower than that discharge (P = 0.04), it within normal range both groups. proportion requiring supplemental oxygen at least 1 reduced 3 4 < 0.05). Gastrointestinal complaints more prevalent but difference not statistically significant 0.12).There no effect primary outcome 6. Gallecina-treated who needed decreased discharge, there other days. possible beneficial effects requirements may warrant further investigation. (Curr Ther Res Clin Exp. 2023; 84:XXX-XXX). Clinical registration: IRCT20201111049347N1.

Language: Английский

Citations

6