Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114546 - 114546

Published: March 21, 2023

As a devastating disease, breast cancer has been responsible for decrease in life expectancy of females and its morbidity mortality are high. Breast is the most common tumor treatment based on employment surgical resection, chemotherapy radiotherapy. The changes biological behavior relies genomic epigenetic mutations depletions as well dysregulation molecular mechanisms that autophagy among them. Autophagy function can be oncogenic increasing tumorigenesis, when it pro-death function, causes reduction viability cells. carcinogenic an impediment towards effective therapy patients, cause drug resistance radio-resistance. important hallmarks such glucose metabolism, proliferation, apoptosis metastasis regulated by autophagy. Oncogenic inhibit apoptosis, while promotes stemness tumor. Moreover, demonstrates interaction with microenvironment components macrophages level anti-tumor compounds therapy. reasons considering pleiotropic dual role (pro-survival pro-death) crosstalk apoptosis. current review provides pre-clinical clinical evaluation

Language: Английский

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Exosomes‐mediated crosstalk between glioma and immune cells in the tumor microenvironment

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(8), P. 2074 - 2085

Published: May 11, 2023

Abstract Gliomas are the most common primary malignant tumors in central nervous system. However, conventional treatments, such as surgical resection and postoperative combined chemo‐ radio‐therapy, ineffective improving patients' long‐term survival. The tumor microenvironment (TME) consists of stromal cells, components, innate acquired immune these along with extracellular matrix, regulate communicate intercellularly to promote TME formation. plays a vital role development glioma. Exosomes, which vesicles (EVs), facilitate intercellular communication regulation within TME. Tumor cells can release exosomes transmit messages, induce macrophage polarization, inhibit cell activity, ultimately promoting metastasis evasion. Moreover, tumorigenesis progression through exosomes. This review summarized biological properties their effects on provides an overview interactions between glioma cells.

Language: Английский

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Long Non-Coding RNAs as Emerging Targets in Lung Cancer

Cancers, Journal Year: 2023, Volume and Issue: 15(12), P. 3135 - 3135

Published: June 10, 2023

Long non-coding RNAs (LncRNAs) are mRNA-like molecules that do not encode for proteins and longer than 200 nucleotides. LncRNAs play important biological roles in normal cell physiology organism development. Therefore, deregulation of their activities is involved disease processes such as cancer. Lung cancer the leading cause cancer-related deaths due to late stage at diagnosis, distant metastasis, high rates therapeutic failure. emerging lung oncogenic or tumor-suppressive functions. highly stable circulation, presenting an opportunity use non-invasive early-stage diagnostic tools. Here, we summarize latest works providing vivo evidence available lncRNAs role development, therapy-induced resistance, potential biomarkers diagnosis prognosis, with a focus on Additionally, discuss current approaches target lncRNAs. The discussed here strongly suggests investigation addition protein-coding genes will provide holistic view molecular mechanisms initiation, progression, could open up new avenue treatment.

Language: Английский

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The pharmacological and biological importance of EZH2 signaling in lung cancer

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114313 - 114313

Published: Feb. 3, 2023

Up to 18% of cancer-related deaths worldwide are attributed lung tumor and global burden this type cancer is ascending. Different factors responsible for development such as smoking, environmental genetic mutations. EZH2 a vital protein with catalytic activity belongs PCR2 family. has been implicated in regulating gene expression by binding promoter targets. The importance discussed current manuscript. Activation significantly elevates the proliferation rate cancer. Furthermore, metastasis associated molecular mechanisms including EMT undergo activation enhancing progression. response therapy can be diminished due upregulation. Since increases progression, anti-cancer agents suppressing its reduce malignancy. In spite significant effort understanding modulatory function on other pathways, it appears that also regulated controlled described review. Therefore, translating findings clinic improve treatment management patients.

Language: Английский

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The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 248, P. 154657 - 154657

Published: July 1, 2023

Language: Английский

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