Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8373 - 8400

Published: Aug. 1, 2024

Despite all major advancements in drug discovery and development the pharmaceutical industry, cancer is still one of most arduous challenges for scientific community. The implications nanotechnology have certainly resolved issues related to conventional anticancer modalities; however, undesired recognition nanoparticles (NPs) by mononuclear phagocyte system (MPS), their poor stability biological fluids, premature release payload, low biocompatibility restricted clinical translation. In recent decades, chitosan (CS)-based nanodelivery systems (eg, polymeric NPs, micelles, liposomes, dendrimers, conjugates, solid lipid nanoparticles, etc.) attained promising from researchers improving pharmacokinetics pharmacodynamics chemotherapeutics. However, specialty this review mainly focus on critically discuss targeting potential various CS-based NPs treatment different types cancer. Based delivery mechanisms, we classified into stimuli-responsive, passive, or active nanosystems. Moreover, functionalization strategies grafting with polyethylene glycol (PEG), hydrophobic substitution, tethering stimuli-responsive linkers, conjugation ligands) adapted architecture CS-NPs target-specific chemotherapeutics also been considered. Nevertheless, based therapeutics hold great promise therapeutic outcomes while mitigating off-target effects chemotherapeutics, a long-term safety profile testing humans are warranted successful

Language: Английский

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Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(44), P. 9125 - 9178

Published: Jan. 1, 2022

Chondroitin sulfate (CS), a natural anionic mucopolysaccharide, belonging to the glycosaminoglycan family, has been in limelight for its unique properties diverse biomedical applications.

Language: Английский

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Lomefloxacin-loaded PLGA hollow nanospheres for healing MRSA-infected diabetic wound; optimization, in vitro and in vivo studies

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106050 - 106050

Published: Aug. 8, 2024

Language: Английский

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Hyaluronic Acid Based Functionalization of Nanodelivery Systems: A Promising Strategy for CD44-Receptors-Mediated Targeted Therapy of Lung Cancer

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106183 - 106183

Published: Sept. 11, 2024

Language: Английский

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Targeting inflammation with hyaluronic acid-based micro- and nanotechnology: A disease-oriented review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135923 - 135923

Published: Sept. 23, 2024

Language: Английский

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CD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 991 - 1020

Published: Jan. 1, 2025

Owing to its high prevalence, colossal potential of chemoresistance, metastasis, and relapse, breast cancer (BC) is the second leading cause cancer-related fatalities in women. Several treatments (eg, chemotherapy, surgery, radiations, hormonal therapy, etc.) are conventionally prescribed for treatment BC; however, these associated with serious systemic aftermaths. In this research, we aimed design a multiprong targeting strategy concurrent action against different phenotypes BC (MCF-7 SK-BR-3) tumor-associated macrophages (TAMs) relapse-free BC. Paclitaxel (PTX) tamoxifen (TMX) co-loaded chitosan (CS) nanoparticles (NPs) were prepared using ionic-gelation method optimized Design Expert® software by controlling material attributes. For selective through CD44-receptors that heavily expressed on cells TAMs, fabricated NPs (PTX-TMX-CS-NPs) functionalized hyaluronic acid (HA) as ligand. The HA-PTX-TMX-CS-NPs exhibited desired physicochemical properties (PS ~230 nm, PDI 0.30, zeta ~21.5 mV), smooth spherical morphology, encapsulation efficiency (PTX ~72% TMX ~97%), good colloidal stability, biphasic release kinetics. Moreover, lowest cell viability depicted MCF-7 (~25%), SK-BR-3 (~20%), RAW 264.7 induction apoptosis, cycle arrest, enhanced internalization, alleviation migration proved superior anticancer compared unfunctionalized other control medicines. HA-functionalization promising CD44-receptors-mediated TAMs mitigate progression, relapse

Language: Английский

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Polyelectrolyte Complex Dry Powder Formulations of Tobramycin with Hyaluronic Acid and Sodium Hyaluronate for Inhalation Therapy in Cystic Fibrosis-Associated Infections

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 169 - 169

Published: Feb. 8, 2025

Background/Objectives: Pulmonary delivered tobramycin (TOB) is a standard treatment for Pseudomonas aeruginosa lung infections, that, along with Staphylococcus aureus, one of the most common bacteria causing recurring infections in CF patients. However, only available formulation on market containing tobramycin, TOBI®, sold at price that makes access to difficult. Therefore, this work focuses development and characterization an ionic complex between polyelectrolyte, hyaluronic acid (HA) its salt, sodium hyaluronate (NaHA), TOB be formulated as inhalable dry powder. Methods: The solid state obtained by spray drying technique was physicochemically characterized infrared spectroscopy, thermal analysis X-ray diffraction, confirming interaction both complexes. Results: powder density, geometric size, morphology aerodynamic performance showed suitable properties formulations reach deep lung. Moisture uptake found low, HA-TOB remaining unchanged, while NaHA-TOB required significant protection against humidity. biopharmaceutical vitro experiments rapid dissolution which can have positively impact reducing side effects, drug release study demonstrated reversible polyelectrolyte–drug interaction. Microbiological P. S. aureus improved bacterial growth inhibition bactericidal efficacy, well better eradication biofilms when compared TOB. Conclusions: A simple polyelectrolyte-drug represents promising strategy antimicrobial pulmonary delivery cystic fibrosis (CF) infections.

Language: Английский

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Hyaluronic acid-functionalized nanomedicines for CD44-receptors-mediated targeted cancer therapy: A review of selective targetability and biodistribution to tumor microenvironment

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142486 - 142486

Published: March 1, 2025

Language: Английский

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Biogenic Amino Acid Cross-Linked Hyaluronic Acid Nanoparticles Containing Dexamethasone for the Treatment of Dry Eye Syndrome

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: March 27, 2025

Language: Английский

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In vitro and in vivo assessment of curcumin-quercetin loaded multi-layered 3D-nanofibroporous matrix prepared by solution blow-spinning for full-thickness burn wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132269 - 132269

Published: May 12, 2024

Language: Английский

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