Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Breast
cancer
is
one
of
the
main
causes
mortality
in
women
globally.
Early
and
accurate
diagnosis
represents
a
milestone
management.
Several
breast
diagnostic
agents
are
available.
Many
chemotherapeutic
conventional
dosage
forms
approved;
nevertheless,
they
lack
cell
specificity,
resulting
improper
treatment
undesirable
side
effects.
Recently,
nanotheranostics
has
emerged
as
new
paradigm
to
achieve
safe
effective
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2022,
Volume and Issue:
34(9), P. 1274 - 1335
Published: Dec. 21, 2022
Cancer
is
still
one
of
the
leading
causes
death
worldwide.
Nanotechnology,
particularly
nanoparticle-based
platforms,
at
edge
current
cancer
management
research.
Polymer-based
nanosystems
have
piqued
interest
researchers
owing
to
their
many
benefits
over
other
conventional
drug
delivery
systems.
Polymers
derived
from
both
natural
and
synthetic
sources
various
biomedical
applications
due
unique
qualities
like
porosity,
mechanical
strength,
biocompatibility,
biodegradability.
such
as
poly(lactic-co-glycolic
acid)
(PLGA),
polycaprolactone
(PCL),
polyethylene
glycol
(PEG)
been
approved
by
USFDA
are
being
researched
for
applications.
They
reported
be
potential
carriers
loading
used
in
theranostic
In
this
review,
we
primarily
focused
on
aforementioned
polymers
conjugates.
addition,
therapeutic
diagnostic
implications
polymer-based
briefly
reviewed.
Furthermore,
safety
developed
polymeric
formulations
crucial,
discussed
biocompatibility
detail.
This
article
also
discusses
recent
developments
block
co-polymer-based
treatment.
The
review
ends
with
challenges
clinical
translation
therapy.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(51), P. 48625 - 48649
Published: Dec. 13, 2023
Breast
cancer
(BC)
is
a
malignant
neoplasm
that
begins
in
the
breast
tissue.
After
skin
cancer,
BC
second
most
common
type
of
women.
At
end
2040,
number
newly
diagnosed
cases
projected
to
increase
by
over
40%,
reaching
approximately
3
million
worldwide
annually.
The
hormonal
and
chemotherapeutic
approaches
based
on
conventional
formulations
have
inappropriate
therapeutic
effects
suboptimal
pharmacokinetic
responses
with
nonspecific
targeting
actions.
To
overcome
such
issues,
use
nanomedicines,
including
liposomes,
nanoparticles,
micelles,
hybrid
etc.,
has
gained
wider
attention
treatment
BC.
Smaller
dimensional
nanomedicine
(especially
50–200
nm)
exhibited
improved
vivo
effectiveness,
as
better
tissue
penetration
more
effective
tumor
suppression
through
enhanced
retention
permeation,
well
active
drug.
Additionally,
nanotechnology,
which
further
extended
developed
theranostic
incorporating
diagnostic
imaging
agents
one
platform,
been
applied
Furthermore,
also
explored
for
gene
delivery
anticancer
therapeutics
Moreover,
nanocarriers'
size,
shape,
surface
charge,
chemical
compositions,
area
play
an
important
role
stability,
cellular
absorption,
cytotoxicity,
uptake,
toxicity.
clinical
translation
managing
remains
slow
process.
However,
few
are
being
used
clinically,
their
progress
current
challenges
addressed
this
Review.
Therefore,
Review
extensively
discusses
recent
advancements
its
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(48), P. 55201 - 55231
Published: Nov. 23, 2023
The
nanomaterial
and
related
toolkit
have
promising
applications
for
improving
human
health
well-being.
Nanobased
drug
delivery
systems
use
nanoscale
materials
as
carriers
to
deliver
therapeutic
agents
in
a
targeted
controlled
manner,
they
shown
potential
address
issues
associated
with
conventional
systems.
They
offer
benefits
treating
various
illnesses
by
encapsulating
or
conjugating
biological
agents,
chemotherapeutic
drugs,
immunotherapeutic
agents.
of
this
technology
are
vast;
however,
significant
challenges
exist
overcome
such
safety
issues,
toxicity,
efficacy,
insufficient
capacity.
This
article
discusses
the
latest
developments
systems,
including
release
mechanisms,
material
toolkits,
design
molecules,
parameters.
concluding
section
examines
limitations
provides
insights
into
future
possibilities.
Intelligent Pharmacy,
Journal Year:
2024,
Volume and Issue:
2(3), P. 415 - 426
Published: April 5, 2024
Breast
cancer
is
the
most
common
malignant
tumour
in
women
worldwide,
as
well
leading
cause
of
death
from
tumours.
All
across
world,
incidence
breast
steadily
rising.
Although
numerous
drugs
acting
through
various
mechanisms
action
are
available
market
conventional
formulations
for
treatment
cancer,
they
face
significant
challenges
terms
bioavailability,
dosing,
and
associated
adverse
effects,
which
severely
limit
their
therapeutic
efficacy.
Several
studies
have
shown
that
nanocarriers
can
significantly
improve
drug's
reducing
need
frequent
dosing
toxicity
linked
to
high
drug
doses.
The
current
review
provides
insight
into
with
oral
nanoparticulate
systems
overcome
problems
formulations.
This
focuses
on
topics,
such
an
in-depth
analysis
potential
anticancer
used
nanocarrier
technology
treat
successfully.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4744 - 4744
Published: April 26, 2024
Cannabidiol
(CBD)
is
a
non-psychoactive
compound
derived
from
Cannabis
sativa.
It
has
demonstrated
promising
effects
in
combating
inflammation
and
holds
potential
as
treatment
for
the
progression
of
chronic
inflammation.
However,
clinical
application
CBD
limited
due
to
its
poor
solubility
bioavailability.
This
study
introduces
an
effective
method
preparing
CBD-loaded
solid
lipid
nanoparticles
(CBD-SLNs)
using
combination
low-energy
hot
homogenization
ultrasonication.
We
enhanced
this
process
by
employing
statistical
optimization
with
response
surface
methodology
(RSM).
The
optimized
CBD-SLN
formulation
utilizes
glyceryl
monostearate
primary
component
nanocarrier.
screened
tool
managing
Stable,
uniformly
dispersed
spherical
size
123
nm,
charge
−32.1
mV,
encapsulation
efficiency
95.16%,
drug
loading
2.36%
were
obtained.
CBD-SLNs
exhibited
sustained
release
properties,
ensuring
prolonged
controlled
delivery,
which
could
potentially
amplify
therapeutic
effects.
Additionally,
we
observed
that
significantly
reduced
both
reactive
oxygen
nitrogen
species
proinflammatory
cytokines
chondrocyte
macrophage
cell
lines,
these
inhibitory
being
more
pronounced
than
those
free
CBD.
In
conclusion,
superiority
over
CBD,
highlighting
delivery
system
Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(8), P. 855 - 873
Published: May 15, 2024
Breast
cancer
presents
a
significant
global
health
challenge,
ranking
highest
incidence
rate
among
all
types
of
cancers.
Functionalised
nanocarriers
offer
promising
solution
for
precise
drug
delivery
by
actively
targeting
cells
through
specific
receptors,
notably
folate
receptors.
By
overcoming
the
limitations
passive
in
conventional
therapies,
this
approach
holds
potential
enhanced
treatment
efficacy
combination
therapy.
Encouraging
outcomes
from
studies
like
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
