Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Breast
cancer
is
one
of
the
main
causes
mortality
in
women
globally.
Early
and
accurate
diagnosis
represents
a
milestone
management.
Several
breast
diagnostic
agents
are
available.
Many
chemotherapeutic
conventional
dosage
forms
approved;
nevertheless,
they
lack
cell
specificity,
resulting
improper
treatment
undesirable
side
effects.
Recently,
nanotheranostics
has
emerged
as
new
paradigm
to
achieve
safe
effective
Therapeutic Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Jan. 29, 2025
Abemaciclib
(ABE)
is
an
anticancer
drug
that
suffers
from
low
bioavailability
and
multidrug
resistance.
This
study
aims
to
develop
ABE-loaded
solid
lipid
nanoparticles
(ABE-SLNs),
which
will
enhance
solubility
lead
increased
cellular
uptake
enhanced
cytotoxicity
when
delivering
tumor
cells.
Melt
emulsification
followed
by
ultrasonication
was
used
as
a
method
of
preparation
Quality-by-Design
(QbD)
utilized
optimize
ABE-SLNs.
The
optimized
ABE-SLNs
consist
Precirol-ATO5
Brij-58
surfactant.
particle
size,
PDI
value,
zeta
potential
the
formulation
were
170.4
±
0.49
nm,
0.25
0.014,
-26.4
0.1
mV,
respectively.
It
also
showed
sustained
release
behavior
high
entrapment
efficiency
79.96%.
exhibited
activity
in
MDA-MB-231
T47D
breast
cancer
cell
lines
compared
pure
ABE.
In
Caco-2
human
colonic
lines,
uptake.
use
QbD
achieve
ABE-SLNs,
coupled
with
cytotoxicity,
represents
novel
approach
could
set
new
standard
for
nanoparticle-based
delivery
systems.
Asia-Pacific Journal of Pharmacotherapy & Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 33 - 43
Published: March 24, 2025
Worldwide,
breast
cancer
remains
the
leading
cause
of
disease
and
mortality
for
women.
Because
its
aggressive
nature
resistance
to
conventional
medicines,
triple
negative
(TNBC)
is
very
challenging
treat.
Through
focused
tactics,
recent
advancements
in
nanocarrier
technology
have
demonstrated
promise
improving
medication
delivery,
optimizing
bioavailability,
raising
drug
concentrations
at
tumor
locations.
Nanoparticles
become
a
useful
tool
studying
imaging,
diagnosis,
targeting
cancer.
Their
advanced
physicochemical
properties
contribute
prolonged
circulation
bloodstream,
as
well
more
efficient
cells.
The
accuracy
with
which
nanoparticles
can
target
tumors
improved
by
both
passive
takes
advantage
characteristics
like
leaky
vasculature,
microenvironment,
or
direct
application
active
makes
use
receptor-specific
antibodies.
By
enhancing
their
ability
cells,
provide
an
over
formulations
that
they
lessen
cytotoxic
effects
anticancer
drugs.
Numerous
based
on
exist
different
phases
preclinical
clinical
development;
most
extensively
investigated
include
polymeric
micelles,
liposomes,
dendrimers,
carbon
nanotubes,
nanorods.
Polymeric
liposomes
been
popular
delivery
vehicles
therapy
during
last
ten
years.
Ongoing
studies
have,
however,
shown
number
these
carriers'
drawbacks.
Consequently,
there
has
interest
hybrid
nanoparticles,
combine
advantages
nanoparticles.
An
overview
developments
field
using
given
this
study.
It
also
stresses
need
early
identification
patient
outcomes
potential
nanocarriers
transform
BC
treatment.
Journal of Microencapsulation,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 31
Published: April 29, 2025
Solid
Lipid
Nanoparticles
(SLNs)
are
versatile
nano-carriers
for
wide
range
of
applications.
The
advantages
SLNs
include
ease
preparation,
low
toxicity,
high
active
compound
bioavailability,
flexibility
incorporating
hydrophilic
and
lipophilic
drugs,
feasibility
large-scale
production.
This
review
provides
an
overview
on
the
preparation
methods
SLNs,
micro
nanostructure
characteristics
different
factors
influencing
sustained
release
targeted
drug
delivery.
applications
in
agriculture
environment,
cosmetics,
wound
healing,
malarial
treatment,
gene
therapy
nano-vaccines,
cancer
therapy,
elaborated.
mechanisms
such
as
passive,
active,
co-delivery
discussed.
issues,
challenges
way
forward
with
ionisable
delivery
vaccines,
RAS-targeted
bioactive
compounds,
highlighted.
In
combination
multiple
compounds
potential
integration
nature/bio-based
solutions,
proven
to
be
effective,
practical
diverse
Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 3, 2024
Breast
cancer
is
one
of
the
main
causes
mortality
in
women
globally.
Early
and
accurate
diagnosis
represents
a
milestone
management.
Several
breast
diagnostic
agents
are
available.
Many
chemotherapeutic
conventional
dosage
forms
approved;
nevertheless,
they
lack
cell
specificity,
resulting
improper
treatment
undesirable
side
effects.
Recently,
nanotheranostics
has
emerged
as
new
paradigm
to
achieve
safe
effective
