Journal of Applied Genetics,
Journal Year:
2023,
Volume and Issue:
65(3), P. 511 - 518
Published: Dec. 29, 2023
Previous
studies
have
demonstrated
an
association
of
the
NC_000012.12:g.53962605A
>
G,
(rs2366152)
single-nucleotide
variant
(SNV)
situated
in
long
noncoding
homeobox
transcript
antisense
intergenic
RNA
(HOTAIR)
gene
with
HPV16-related
cervical
cancer
pathogenesis.
However,
little
is
known
about
role
rs2366152
progression
and
how
oral
birth
control
pills
use,
parity,
menopausal
status,
cigarette
smoking
influence
carcinogenesis.
HRM
analysis
was
used
to
determine
SNV
prevalence
patients
squamous
cell
carcinoma
(SCC)
(n
=
470)
group
499)
a
Polish
Caucasian
population.
Logistic
regression
analyses
were
adjusted
for
age,
using
pills,
smoking.
Our
genetic
revealed
that
G/A
vs.
A/A
(p
0.031,
p
0.002)
+
G/G
0.035,
0.003)
genotypes
significantly
related
grade
differentiation
G3
tumor
stage
III,
respectively.
Moreover,
risk
increased
among
who
smoked
cigarettes
pills.
We
conclude
may
promote
invasion
rapid
growth
SCC.
can
also
be
factor
cancerogenesis.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: March 9, 2023
Most
of
our
transcribed
RNAs
are
represented
by
non-coding
sequences.
Long
(lncRNAs)
transcripts
with
no
or
very
limited
protein
coding
ability
and
a
length
>200nt.
They
can
be
epigenetically
modified.
N6-methyladenosine
(m6A),
N1-methyladenosine
(m1A),
5-methylcytosine
(m5C),
7-methylguanosine
(m7G)
2’-O-methylation
(Nm)
some
the
lncRNAs
epigenetic
modifications.
The
modifications
RNA
controlled
three
classes
enzymes,
each
playing
role
in
specific
phase
modification.
These
enzymes
defined
as
“writers”,
“readers”
“erasers”.
m6A
m5C
most
studied
RNA.
alter
structure
properties,
thus
modulating
functions
interactions
lncRNAs.
aberrant
expression
several
is
linked
to
development
variety
cancers
signatures
m6A-
m5C-related
increasingly
recognized
potential
biomarkers
prognosis,
predictors
disease
stage
overall
survival.
In
present
manuscript,
up
date
literature
reviewed
focus
on
their
significance
cancer.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 234 - 234
Published: Jan. 13, 2025
The
complex
signaling
network
within
the
breast
tumor
microenvironment
is
crucial
for
its
growth,
metastasis,
angiogenesis,
therapy
escape,
stem
cell
maintenance,
and
immunomodulation.
An
array
of
secretory
factors
their
receptors
activate
downstream
cascades
regulating
cancer
progression
metastasis.
Among
various
pathways,
EGFR,
ER,
Notch,
Hedgehog
pathways
have
recently
been
identified
as
in
terms
proliferation,
survival,
differentiation,
maintenance
CSCs,
failure.
These
mediate
such
MAPK,
including
MEK/ERK
that
promote
common
pro-oncogenic
signaling,
whereas
dysregulation
PI3K/Akt,
Wnt/β-catenin,
JAK/STAT
activates
key
oncogenic
events
drug
resistance,
CSC
enrichment,
metabolic
reprogramming.
Additionally,
these
orchestrate
an
intricate
interplay
between
stromal
cells,
immune
cells.
Metabolic
reprogramming
adaptations
contribute
to
aggressive
are
unresponsive
therapy.
Herein,
recent
insights
into
novel
operating
TME
aid
advancement
emphasized
current
developments
practices
targeting
enhance
treatment
efficacy
reviewed.
Biomarkers in Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Jan. 27, 2025
Glioblastoma
multiforme
(GBM)
is
an
aggressive
brain
tumor.
This
meta-analysis
investigates
the
association
between
HOTAIR
expression
levels
and
GBM.
We
searched
literature
for
studies
on
in
GBM
patients.
A
of
nine
assessed
standardized
mean
difference
(SMD)
95%
confidence
intervals
(CIs)
using
a
random-effects
model.
Subgroup
analyses
were
performed
based
sample
source,
country,
study
design.
Additionally,
we
conducted
meta-regression
publication
bias
analyses.
The
found
significant
positive
elevated
(SMD
=
8.3,
CI
5.8-10.8,
p
0.00).
Considerable
heterogeneity
was
observed
(Q-value:
1174.2,
df
9,
I2
99.2%,
indicated
associations
tissue
samples
from
USA
China.
Meta-regression
revealed
that
design
country
contributed
to
heterogeneity,
with
no
detected.
analysis
confirms
link
GBM,
highlighting
as
potential
therapeutic
target
biomarker.
Further
research
necessary
clarify
biological
mechanisms
involved
this
association.
Cells,
Journal Year:
2025,
Volume and Issue:
14(5), P. 388 - 388
Published: March 6, 2025
Metabolic
reprogramming
plays
a
crucial
role
in
cancer
biology
and
the
mechanisms
underlying
its
regulation
represent
promising
study
area.
In
this
regard,
discovery
of
non-coding
RNAs
opened
new
regulatory
landscape,
which
is
early
stages
investigation.
Using
differential
expression
model
HOTAIR,
we
evaluated
level
metabolic
enzymes,
as
well
metabolites
produced
by
glycolysis
glutaminolysis.
Our
results
demonstrated
effect
HOTAIR
on
glutaminolysis
enzymes
colorectal
cells.
Specifically,
through
overexpression
inhibition
determined
influence
PFKFB4,
PGK1,
LDHA,
SLC1A5,
GLUD1,
GOT1,
had
direct
impact
lactate
glutamate
production.
These
findings
indicate
that
significant
producing
“oncometabolites”
essential
to
maintaining
bioenergetics
biomass
necessary
for
tumor
cell
survival
regulating
Epigenomics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 24
Published: March 5, 2025
Solid
tumors
are
significant
causes
of
global
mortality
and
morbidity.
Recent
research
has
primarily
concentrated
on
finding
pathology-specific
molecules
that
can
be
acquired
non-invasively
change
as
the
disease
progresses
or
in
response
to
treatment.
The
focus
moved
RNA
either
freely
circulating
body
fluids
bundled
microvesicles
exosomes
because
their
great
stability
challenging
environments,
ease
accessibility,
changes
level
therapy.
In
this
context,
there
many
non-coding
RNAs
used
for
purpose
liquid
biopsies.
Out
these,
microRNAs
have
been
extensively
studied.
However,
an
increase
interest
studying
long
RNAs,
piwi
interacting
circular
other
small
RNAs.
article,
overview
most
researched
solid
will
reviewed,
along
with
a
discussion
significance
these
early
diagnosis,
prognosis,
therapeutic
targets.
publications
analyzed
were
extracted
from
PubMed
database
between
2008
June
2024.
Jundishapur Journal of Natural Pharmaceutical Products,
Journal Year:
2025,
Volume and Issue:
20(2)
Published: March 30, 2025
Background:
Despite
advances
in
medical
science
the
field
of
cancer,
treatment
glioblastoma
(GBM)
remains
a
significant
challenge
due
to
its
high
degree
penetration
and
formation
resistant
cells.
Among
effective
herbal
compounds
cancer
treatment,
curcumin
is
known
be
one
most
effective.
Curcumin
has
potential
modulate
critical
pathways
involved
cell
proliferation,
apoptosis,
cycle
arrest,
oxidative
stress,
epigenetic
processes.
Objectives:
In
this
research,
we
investigated
effects
nanoparticles
(curcumin-NPs)
on
expression
DNMT3A,
SUZ12,
HOTAIR
genes,
MecP2
as
important
factors
line.
Methods:
NPs
were
synthesized
using
ultrasonic
methods,
their
toxic
1321N1
line
measured
48
hours
after
MTT
assay.
RT-qPCR
Western
blot
used
measure
levels
different
factors,
including
protein.
Results:
The
results
showed
50%
inhibitory
effect
at
IC50
concentration
(1.7μM)
curcumin-NPs
prepared
by
method
can
reduce
invasion,
growth,
migration
Also,
decrease
was
found
HOTAIR,
protein
curcumin-NPs,
which
statistically
(mean
±
SD,
n
=
2,
P
<
0.05).
Conclusions:
Our
study
demonstrated
that
affect
viability
proliferation
mediating
level
some
essential
regulators.
Egyptian Liver Journal,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 18, 2024
Abstract
Background
Pancreatic
adenocarcinoma,
recognized
for
its
aggressive
behavior
and
frequent
late-stage
diagnosis,
imposes
significant
challenges
in
early
detection
prognosis.
This
study
aimed
to
evaluate
the
diagnostic
prognostic
potential
by
measuring
expression
levels
of
long
non-coding
RNA
HOTAIR
glycolytic
enzyme
hexokinase
2
(HK2)
mRNA
both
tumorous
adjacent
non-tumorous
pancreatic
tissue
samples
(
n
=
25
each)
using
RT-qPCR.
Results
Both
lncRNA
HK2
significantly
increased
tissues
compared
P
0.001).
However,
their
stage
T2
T3
showed
no
statistically
difference
0.01).
positively
correlated
with
each
other
0.001;
r
0.95);
however,
associations
were
found
serum
tumor
markers
CA19-9
CEA
0.01;
005;
p
0.1,
0.2).
ROC
analysis
demonstrated
abilities
discriminate
between
(AUC
0.92
0.84,
respectively)
96%
88%
sensitivity,
72%
40%
specificity,
respectively,
at
optimal
cut-off
values
1.12
0.84
relative
units.
Patients
elevated
had
shorter
median
survival
(8
7
months,
respectively),
increasing
risk
adverse
outcomes
or
recurrence
4–4.8
times
(HR
4.08,
0.07;
HR
4.8,
0.01),
thus
emphasizing
cancer.
Conclusion
exhibit
tumors.
Elevated
correlate
strongly
outcomes,
underscoring
value.
