Impact of Low PM2.5 Exposure on Asthma Admission: Age-Specific Differences and Evidence from a Low-Pollution Environment in China DOI Creative Commons
Xiaolong Fan,

Chen Yang,

Jinsheng Chen

et al.

Aerosol and Air Quality Research, Journal Year: 2023, Volume and Issue: 24(2), P. 230195 - 230195

Published: Dec. 12, 2023

Many epidemiological studies focus on health research in areas with high concentration of PM2.5. To fill the gap, our study investigated acute effects low PM2.5 level (annual average below 35 μg m-³) asthma admissions Xiamen, China. Using a time-stratified case-crossover design, we examined association between and from January 2019 to November 2021. The results showed positive correlation cumulative incidence asthma, lag 0-7 days. Each 10 m-3 increased was associated 0.49% increase incidence. Stratified analysis revealed significant children aged 0-4 years (OR = 2.029, 95% CI 1.359-3.031) elderly population over 75 1.399, 1.092-1.793). Distributed models demonstrated hysteresis effect, lagged observed (lag0-5) (lag3-lag5). multi-pollutant model, considering NO2 O3, consistent results. These findings highlight age-specific susceptibility exposure its impact admissions, even at lower levels pollution. Further is needed inform environmental protection policies public interventions low-pollution environments.

Language: Английский

TRP Channels in Cancer: Therapeutic Opportunities and Research Strategies DOI Creative Commons
Jiahui Xu, Ziming Wang, Yuqing Niu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107412 - 107412

Published: Sept. 19, 2024

Language: Английский

Citations

4
Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases DOI Creative Commons
Wenxin Wang, Tao Sun

Molecules, Journal Year: 2023, Volume and Issue: 29(1), P. 181 - 181

Published: Dec. 28, 2023

Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective cation channel protein, which can be activated by various physical chemical stimuli. Recent studies have shown the strong pathogenetic associations of TRPV1 with neurodegenerative diseases (NDs), in particular Alzheimer’s disease (AD), Parkinson’s (PD) multiple sclerosis (MS) via regulating neuroinflammation. Therapeutic effects agonists antagonists on treatment AD PD animal models also are emerging. We here summarize current understanding TRPV1’s its as therapeutic means diseases, highlight future strategies using natural agonists. Developing new targets applying products becoming promising direction chronic disorders, especially diseases.

Language: Английский

Citations

8
Neuroimmune communication in allergic rhinitis DOI Creative Commons
Yiting Zhou,

Ru Chen,

Lili Kong

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 21, 2023

The prevalence rate of allergic rhinitis (AR) is high worldwide. inhalation allergens induces AR, which an immunoglobulin E-mediated and type 2 inflammation-driven disease. Recently, the role neuroimmune communication in AR pathogenesis has piqued interest scientific community. Various neuropeptides, such as substance P (SP), vasoactive intestinal peptide (VIP), calcitonin gene-related (CGRP), nerve growth factor (NGF), neuromedin U (NMU), released via “axon reflexes” or “central sensitization” exert regulatory effects on immune cells to elicit “neurogenic inflammation,” contributes nasal hyperresponsiveness (NHR) AR. Additionally, neuropeptides can be produced cells. frequent colocalization neuronal at certain anatomical regions promotes establishment cell units, nerve-mast cells, nerve-type innate lymphoid (ILC2s), nerve-eosinophils nerve-basophils units. Receptors expressed both neurons, TRPV1, TRPA1, Mas-related G protein-coupled receptor X2 (MRGPRX2) mediate pathogenesis. This review focused elucidating mechanisms underlying

Language: Английский

Citations

7
Development of a dry powder formulation for pulmonary delivery of azithromycin-loaded nanoparticles DOI Creative Commons
Asma Sani,

Khellida Loiane V. Ramos-Rocha,

Michelle Alvares Sarcinelli

et al.

Journal of Pharmacy & Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 27

Published: Oct. 14, 2024

The COVID-19 pandemic has raised concern regarding respiratory system diseases and oral inhalation stands out as an attractive non-invasive route of administration for pulmonary such chronic bronchitis, cystic fibrosis, community-acquired pneumonia. In this context, we encapsulated azithromycin in polycaprolactone nanoparticles functionalized with phospholipids rich dipalmitoylphosphatidylcholine further produced a fine powder formulation by spray drying monohydrated lactose. Nanoparticles obtained the emulsion/solvent diffusion-evaporation technique exhibited mean hydrodynamic diameter around 195–228 nm narrow monomodal size distribution (PdI < 0.2). Nanoparticle dispersions were spray-dried at different inlet temperatures, atomizing air-flow, aspirator air flow, feed rate, using lactose aid, resulting maximal process yield 63% encapsulation efficiency 83%. Excipients dry formulations characterized terms morphology, chemical structure, thermal analyses particle SEM, FTIR, DSC/TGA laser light diffraction. results indicated spherical particles 90% 4.06 µm or below, adequate delivery. Aerosolization performance NGI confirmed good aerodynamic properties. Microbiological assays showed that preserves AZM antimicrobial effect against Staphylococcus aureus Streptococcus pneumoniae strains, halos above 18 mm. addition, no formulation-related cytotoxicity was observed human cell lines BEAS-2B (lung epithelial), HUVEC (endothelial) HFF1 (fibroblasts). Overall, approach described here allows production AZM-PCL incorporated into inhalable microparticles, enabling more efficient therapy lung infections.

Language: Английский

Citations

2
Mechanism of electroacupuncture at acupoints of the lung meridian through PKA/PKC regulation of TRPV1 in chronic cough after lung surgery in guinea pigs DOI Open Access
Gao‐Xiang Wang, Jie Zhou,

You-Mou Chen

et al.

Journal of Thoracic Disease, Journal Year: 2023, Volume and Issue: 15(4), P. 1848 - 1860

Published: April 1, 2023

Acupuncture has achieved good results in the treatment of cough, asthma, chronic obstructive pulmonary disease (COPD) and other lung diseases, but mechanism associated with acupuncture cough induced by surgery is unknown. We investigated whether therapy could improve symptoms after through cyclic-AMp dependent protein kinase A (PKA)/cyclic-AMp C (PKC) regulation transient receptor potential vanilloid-1 (TRPV1) signaling pathway.The guinea pigs were divided into 5 groups: Sham operation Group (Sham), Model (Model), Electroacupuncture + (EA M), H89 (H89 M) Go6983 (Go6983 M). The effect was determined measuring (number coughs/cough incubation period) as outcome criterion. levels inflammatory cytokines bronchoalveolar lavage fluid (BALF) blood enzyme-linked immunosorbent assays (ELISA). Lung tissue stained hematoxylin eosin (H&E). expression p-PKA, p-PKC p-TRPV1 proteins measured Western blotting. mRNA TRPV1, Substance P (SP), calcitonin gene-related peptide (CGRP) neurokinin-1R (NK1R) real-time polymerase chain reaction (RT-PCR).Acupuncture significantly reduced frequency prolonged latency surgery. In addition, damage to tissue. decreased all groups, inhibited SP, CGRP NK1R treatment.Acupuncture ameliorated regulating TRPV1 pathway via PKA/PKC. Our showed that may be an effective surgery, also clarified mechanism, which provides a theoretical basis for clinical patients

Language: Английский

Citations

6
The Noninvasive Sonothermogenetics Used for Neuromodulation in M1 Region of Mice Brain by Overexpression of TRPV1 DOI
Lulu Wang,

Guanglei Chang,

Miaomiao Yang

et al.

Neuroscience, Journal Year: 2023, Volume and Issue: 527, P. 22 - 36

Published: July 21, 2023

Language: Английский

Citations

5
TRPV: An emerging target in glaucoma and optic nerve damage DOI
Xiaotong Zhang, Feng Wang, Ying Su

et al.

Experimental Eye Research, Journal Year: 2024, Volume and Issue: 239, P. 109784 - 109784

Published: Jan. 8, 2024

Language: Английский

Citations

1
The Extract from Quzhou Aurantii Fructus Attenuates Cough Variant Asthma through Inhibiting the TRPV1/Ca2+/NFAT/TSLP Pathway and Ferroptosis via TRPV1 Mediation in Ovalbumin-induced Mice DOI
Meizi Tian, Wenkang Huang, Jiahui Chen

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119038 - 119038

Published: Nov. 6, 2024

Language: Английский

Citations

1
Integrative network pharmacology and multi-omics to study the potential mechanism of Niuhuang Shangqing Pill on acute pharyngitis DOI
Yuhao Gu,

Manting Liu,

Nan Niu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119100 - 119100

Published: Nov. 13, 2024

Language: Английский

Citations

1
Multidisciplinary diagnosis and treatment model based on a retrospective cohort study: Pulmonary function and prognosis quality of life in severe COPD DOI

Linghua Liu,

Hui Ke

Technology and Health Care, Journal Year: 2023, Volume and Issue: 32(1), P. 313 - 326

Published: April 28, 2023

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory worsening airflow limitation. OBJECTIVE: To explore function rehabilitation, life quality and prognosis in patients with severe COPD. METHODS: Between February 2018 August 2021, 150 COPD cured our hospital were arbitrarily assigned into the control group (n= 75) study 75). The received routine treatment research multidisciplinary diagnosis treatment. body mass index, obstruction, dyspnea exercise (BODE), function, number of acute attacks, 6-minute walking distance (6MWD), Borg score compared. RESULTS: There was no remarkable difference BODE before (P> 0.05). During 2- 6-month following treatment, lower (P< In group, FEV1 percentage predicted value, forced expiratory volume one second (PPO-FEV1) second/forced vital capacity (FEV1/FVC) first higher there fewer attacks After 6MWD scores at 6-months after differences 0.05), however, symptom score, activity influence total CONCLUSION: application model can promote rehabilitation COPD, improve their prognosis, slow down development enhance quality.

Language: Английский

Citations

3