Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(5), P. 1866 - 1908
Published: July 7, 2024
Abstract
The
escalating
global
cancer
burden
underscores
the
urgent
need
for
more
effective
therapeutic
strategies.
Phytochemicals,
naturally
occurring
compounds
in
plants,
have
garnered
attention
their
potential
chemoprevention
and
chemotherapy.
Their
ability
to
modulate
molecular
mechanisms
influence
cell
signaling
pathways
offers
a
promising
avenue
management.
This
review
aims
synthesize
current
knowledge
on
phytochemicals’
chemopreventive
chemotherapeutic
potential,
focusing
of
action
impacts
involved
cancer.
A
systematic
literature
search
was
conducted
across
major
databases,
including
PubMed/Medline,
Web
Science,
Scopus,
Google
Scholar.
strategy
uses
Medical
Subject
Headings
(MeSH)
free‐text
terms
using
Boolean
operators
capture
relevant
studies.
Inclusion
criteria
targeted
original
research
reviews
effects
phytochemicals
cancer,
with
specific
focus
mechanisms.
flavonoids,
polyphenols,
terpenoids,
demonstrated
significant
anticancer
properties
by
inducing
cycle
arrest,
apoptosis,
autophagy.
They
critical
pathways,
such
as
cyclooxygenase‐2,
nuclear
factor
kappa
B,
various
growth
factor‐related
rectify
epigenetic
alterations,
contributing
effects.
Phytochemicals
represent
valuable
resource
developing
novel
prevention
treatment
strategies;
actions
underscore
combat.
Further
is
warranted
translate
these
findings
into
clinical
applications,
optimizing
phytochemical‐based
interventions
Journal of Cellular and Molecular Medicine,
Journal Year:
2023,
Volume and Issue:
28(1)
Published: Dec. 22, 2023
Abstract
Breast
cancer
is
the
most
prevalent
worldwide
and
its
incidence
increases
with
age,
posing
a
significant
threat
to
women's
health
globally.
Due
clinical
heterogeneity
of
breast
cancer,
majority
patients
develop
drug
resistance
metastasis
following
treatment.
Ferroptosis,
form
programmed
cell
death
dependent
on
iron,
characterized
by
accumulation
lipid
peroxides,
elevated
levels
iron
ions
peroxidation.
The
underlying
mechanisms
signalling
pathways
associated
ferroptosis
are
intricate
interconnected,
involving
various
proteins
enzymes
such
as
cystine/glutamate
antiporter,
glutathione
peroxidase
4,
inhibitor
1
dihydroorotate
dehydrogenase.
Consequently,
emerging
research
suggests
that
may
offer
novel
target
for
treatment;
however,
in
urgently
require
resolution.
Additionally,
certain
natural
compounds
have
been
reported
induce
ferroptosis,
thereby
interfering
cancer.
Therefore,
this
review
not
only
discusses
molecular
multiple
mediate
(including
metastasis,
invasion
proliferation)
but
also
elaborates
which
Furthermore,
summarizes
potential
compound
types
serve
inducers
future
tumour
cells,
providing
lead
development
ferroptosis‐inducing
agents.
Last,
proposes
synergy
combining
traditional
drugs
treatment
suggesting
directions
offering
new
insights.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(3), P. 1329 - 1344
Published: Jan. 9, 2024
Abstract
Cancer
is
a
highly
heterogeneous
disease
that
poses
serious
threat
to
human
health
worldwide.
Despite
significant
advances
in
the
diagnosis
and
treatment
of
cancer,
prognosis
survival
rate
cancer
remain
poor
due
late
diagnosis,
drug
resistance,
adverse
reactions.
Therefore,
it
very
necessary
study
development
mechanism
formulate
effective
therapeutic
interventions.
As
widely
available
bioactive
substances,
natural
products
have
shown
obvious
anticancer
potential,
especially
by
targeting
abnormal
epigenetic
changes.
The
main
active
part
garlic
organic
sulfur
compounds,
which
diallyl
trisulfide
(DATS)
content
highest,
accounting
for
more
than
40%
total
composition.
garlic‐derived
compounds
been
recognized
as
an
antioxidant
prevention
treatment.
However,
molecular
antitumor
effect
remains
unclear.
Recent
studies
identified
compound
DATS
plays
critical
roles
enhancing
CpG
demethylation
or
promoting
histone
acetylation
inhibitor.
Here,
we
review
progress
against
through
pathways.
The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
52(02), P. 565 - 581
Published: Jan. 1, 2024
L48H37
is
a
synthetic
curcumin
analog
that
has
anticancer
potentials.
Here,
we
further
explored
the
effect
of
on
oral
cancer
cells
and
its
mechanistic
acts.
Cell
cycle
distribution
was
assessed
using
flow
cytometric
analysis.
Apoptosis
elucidated
by
staining
with
PI/Annexin
V
activation
caspase
cascade.
Cellular
signaling
apoptotic
protein
profiling,
Western
blotting,
specific
inhibitors.
Our
findings
showed
significantly
reduced
cell
viability
SCC-9
HSC-3
cells,
resulting
in
sub-G1
phase
accumulation
increased
cells.
Apoptotic
profiling
revealed
cleaved
caspase-3,
downregulated
cellular
inhibitor
apoptosis
1
(cIAP1)
X-linked
(XIAP)
cIAP1
XIAP
both
were
also
demonstrated
blotting.
Meanwhile,
triggered
caspases
mitogen-activated
kinases
(MAPKs).
The
involvement
c-Jun
N-terminal
kinase
(JNK)
p38
MAPK
(p38)
L48H37-triggered
cascade
Collectively,
these
indicate
potent
activity
against
which
may
be
attributed
to
JNK/p38-mediated
apoptosis.
This
suggests
potential
benefit
for
treatment
cancer.
Meme sağlığı dergisi/Meme sağlığı dergisi,
Journal Year:
2024,
Volume and Issue:
20(2), P. 102 - 109
Published: March 27, 2024
Recent
research
suggests
curcumin
extracted
from
the
turmeric
plant
may
inhibit
proliferation
of
cancer
cells
by
controlling
expression
microRNAs
(miRNAs).
The
effect
phenolic
on
miR-638-5p
and
potential
target
gene
expressions
in
triple
negative
breast
(TNBC)
cell
line
MDA-MB-231
was
investigated
this
study.
Food Frontiers,
Journal Year:
2024,
Volume and Issue:
5(5), P. 1866 - 1908
Published: July 7, 2024
Abstract
The
escalating
global
cancer
burden
underscores
the
urgent
need
for
more
effective
therapeutic
strategies.
Phytochemicals,
naturally
occurring
compounds
in
plants,
have
garnered
attention
their
potential
chemoprevention
and
chemotherapy.
Their
ability
to
modulate
molecular
mechanisms
influence
cell
signaling
pathways
offers
a
promising
avenue
management.
This
review
aims
synthesize
current
knowledge
on
phytochemicals’
chemopreventive
chemotherapeutic
potential,
focusing
of
action
impacts
involved
cancer.
A
systematic
literature
search
was
conducted
across
major
databases,
including
PubMed/Medline,
Web
Science,
Scopus,
Google
Scholar.
strategy
uses
Medical
Subject
Headings
(MeSH)
free‐text
terms
using
Boolean
operators
capture
relevant
studies.
Inclusion
criteria
targeted
original
research
reviews
effects
phytochemicals
cancer,
with
specific
focus
mechanisms.
flavonoids,
polyphenols,
terpenoids,
demonstrated
significant
anticancer
properties
by
inducing
cycle
arrest,
apoptosis,
autophagy.
They
critical
pathways,
such
as
cyclooxygenase‐2,
nuclear
factor
kappa
B,
various
growth
factor‐related
rectify
epigenetic
alterations,
contributing
effects.
Phytochemicals
represent
valuable
resource
developing
novel
prevention
treatment
strategies;
actions
underscore
combat.
Further
is
warranted
translate
these
findings
into
clinical
applications,
optimizing
phytochemical‐based
interventions
