CAML Model for Computational Biology DOI

Parimal Pal Chaudhuri,

Adip Dutta,

Somshubhro Pal Choudhury

et al.

Published: Jan. 1, 2025

Language: Английский

Pharmaceutical applications of endophytic fungi: current successes and future prospects DOI

Ankita Arora,

P.L. Bharti, Gurleen Kaur Sodhi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 55 - 73

Published: Jan. 1, 2025

Language: Английский

Citations

0
Antitumor and immunomodulatory activities of diphyllin and its derivatives DOI
Yulin Ren, Judith C. Gallucci, Jianhua Yu

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118197 - 118197

Published: April 1, 2025

Language: Английский

Citations

0
GC-MS, LC-MS, and network pharmacology analysis to investigate the chemical profiles and potential pharmacological activities in flower buds and flowers of Lonicera japonica Thunb DOI Creative Commons
Kai Tong, Lingyun Dai, W. B. Rui

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320293 - e0320293

Published: April 23, 2025

Lonicera japonica Thunb. ( L. ) is an edible-medicinal herb. While the flower buds of are commonly utilized for medicinal purposes, flowers often overlooked. However, it has been discovered that contain higher levels certain active compounds compared to buds. Despite this finding, there have no reports on potential differences in pharmacological efficacy between these compounds. Utilizing results from GC-MS and LC-MS, a total 335 differential were identified, which 247 complied with Lipinski’s Rule Five concerning properties. Among these, 101 upregulated buds, while 146 flowers. Network pharmacology analysis revealed targeted 143 185 core targets, respectively, 116 being duplicates. The target proteins among duplicate targets primarily involved pathways related cancer, lipid atherosclerosis, hepatitis B, proteoglycans Alzheimer’s disease. Meanwhile, hub enriched distinct associated human T-cell leukemia virus 1 infection, focal adhesion, thyroid hormone signaling pathway, fluid shear stress atherosclerosis. Molecular docking indicated exhibited strong binding affinity targets. This study provides insights into components (flower buds) non-medicinal (flowers) raw materials predicting mechanisms action establishing basis more rational utilization

Language: Английский

Citations

0
Natural products target programmed cell death signaling mechanisms to treat colorectal cancer DOI Creative Commons
Ya Zheng, Na Feng,

C W Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 24, 2025

As a highly prevalent gastrointestinal malignant tumor, colorectal cancer poses serious challenge in terms of increasing morbidity and mortality late diagnosis due to the invisibility disease. Although existing therapies are diverse but limited efficacy, mechanism programmed cell death (PCD) has become focus research its central role maintaining body homeostasis regulating tumor progression. Multimodal pathways, such as apoptosis, autophagy, pyroptosis ferroptosis, have shown unique advantages inhibiting proliferation migration cells enhancing sensitivity chemotherapy by responding internal external environmental stimuli. In recent years, natural products risen prominence virtue their multi-target synergistic effects chemo-sensitizing properties, opened up new direction for treatment precisely PCD pathway. this paper, we searched PubMed, Web Science CNKI databases relevant studies last 10 years using keywords (Colorectal cancer) (programmed death) products. This work retrieved 59 (55 from past 5 4 years) reveal action targeting PCD, aiming provide theoretical support practical guidance optimization clinical therapeutic strategies development innovative drugs.

Language: Английский

Citations

0
CAML Model for Computational Biology DOI

Parimal Pal Chaudhuri,

Adip Dutta,

Somshubhro Pal Choudhury

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0