Vietnam Journal of Biotechnology,
Journal Year:
2024,
Volume and Issue:
22(2), P. 318 - 328
Published: June 30, 2024
Ageratum
conyzoides
L.
is
widely
used
for
the
treatment
of
skin
wound
in
some
communities
Asia,
Africa,
and
South
America,
including
Vietnam.
In
this
study,
we
demonstrated
that
70%
ethanol
extract
A.
leaves
collected
Bidoup
National
Park,
Nui
Ba,
Lam
Dong,
Vietnam
had
properties
would
be
advantageous
wounds.
Firstly,
found
contained
64.9±2.58
mgGAE/gE
polyphenols
79.33±1.03
mgQE/gE
flavonoids,
antioxidant
activity
with
IC50
131.74±2.67
µg/mL.
This
was
also
proven
to
have
antimicrobial
activities
against
pathogenic
bacteria,
S.
aureus,
P.
aeruginosa,
E.
faecalis,
coli.
We
could
inhibit
generation
nitric
oxide
LPS-activated
Raw
264.7
cells,
indicating
its
vitro
anti-inflammatory
activity.
And
finally,
first
time,
promote
proliferation
fibroblast
NIH-3T3
cell
line.
All
together,
these
findings
support
traditional
use
plant
treatment.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
279, P. 116483 - 116483
Published: May 23, 2024
Oxidative
stress
and
inflammation
play
a
fundamental
role
in
the
beginning
advancement
of
silicosis.
Hence,
questing
active
phytocompounds
(APCs)
with
anti-oxidative
anti-inflammatory
properties
such
as
diosgenin
(DG)
emodin
(ED)
can
be
therapeutic
intervention
targeting
silica-induced
pulmonary
fibrosis.
Hydrophobicity
low
bioavailability
are
barriers
that
restrict
efficacy
DG
ED
against
defects.
Encapsulating
these
APCs
polymeric
nanoparticles
overcome
this
limitation.
The
present
study
has
thus
explored
anti-fibrotic
effects
polylactic-co-glycolic
acid
(PLGA)
(NPs)
individually
loaded
(DGn)
or
(EDn)
combine
DG+ED
[(DG+ED)n]
respirable
silica
dust
(RSD)-induced
fibrosis
silicosis
rat
model.
Our
found
individual
combined
NPs
revealed
physiochemical
characteristics
appropriate
for
IV
administration
sustained-drug
release
purposes.
Physiological
evaluations
RSD-induced
rats
suggested
no
treatment
could
improve
body
weight.
Still,
they
reduced
lung
coefficient
by
maintaining
moisture.
Only
(DG+ED)n
significantly
cleared
free
silica.
All
interventions
were
to
attribute
increased
per
cent
cell
viability
BALF,
reduce
cytotoxicity
via
minimizing
LDH
levels,
balance
oxidant-antioxidant
status
silicotic
rats.
expression
inflammatory
cytokines
(TNF-α,
IL-1β,
IL-6,
MCP-1,
TGF-β1)
efficiently
down-regulated
compared
pure
(DG+ED)
treatment.
drug
treatments
declined,
8-HdG
HYP
productions
indicate
oxidative
DNA
damage
collagen
deposition
successfully
repaired.
Moreover,
histopathological
investigations
proposed
drugs
decrease
alveolitis
grades
However,
inhibited
In
conclusion,
RSD
induce
rats,
producing
reactive
oxygen
species
(ROS)-mediated
cells
leading
development.
NP
suppressed
formation
effectively
interrupting
fibrosis-silicosis
progression.
These
results
may
attributed
improved
through
their
nano-encapsulation-mediated
targeted
delivery.
Vietnam Journal of Biotechnology,
Journal Year:
2024,
Volume and Issue:
22(2), P. 318 - 328
Published: June 30, 2024
Ageratum
conyzoides
L.
is
widely
used
for
the
treatment
of
skin
wound
in
some
communities
Asia,
Africa,
and
South
America,
including
Vietnam.
In
this
study,
we
demonstrated
that
70%
ethanol
extract
A.
leaves
collected
Bidoup
National
Park,
Nui
Ba,
Lam
Dong,
Vietnam
had
properties
would
be
advantageous
wounds.
Firstly,
found
contained
64.9±2.58
mgGAE/gE
polyphenols
79.33±1.03
mgQE/gE
flavonoids,
antioxidant
activity
with
IC50
131.74±2.67
µg/mL.
This
was
also
proven
to
have
antimicrobial
activities
against
pathogenic
bacteria,
S.
aureus,
P.
aeruginosa,
E.
faecalis,
coli.
We
could
inhibit
generation
nitric
oxide
LPS-activated
Raw
264.7
cells,
indicating
its
vitro
anti-inflammatory
activity.
And
finally,
first
time,
promote
proliferation
fibroblast
NIH-3T3
cell
line.
All
together,
these
findings
support
traditional
use
plant
treatment.
