Phytochemical composition, in vitro cytotoxicity and in silico ADME/Tox analysis of the active compounds of Oxalis latifolia Kunth. extracts with promising anticancer potential DOI
Arumugam Vignesh,

Karuppasamy Dharani,

S. Selvakumar

et al.

3 Biotech, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

Language: Английский

Evaluation of antidiabetic and antioxidant effects of Polygonum cognatum Meisn. and phytochemical analysis of effective extracts DOI
Sefa Gözcü, Rüstem Anıl Uğan, Hilal Özbek

et al.

Biomedical Chromatography, Journal Year: 2023, Volume and Issue: 38(3)

Published: Dec. 18, 2023

Abstract Polygonum cognatum Meisn. (Polygonaceae) is used both as food and a folk medicine to treat diabetes. This study aimed evaluate the effect of extracts, along with isolated compounds, from P. aerial parts on In vitro studies were conducted using an α ‐glucosidase inhibitory assay, while in vivo antidiabetic carried out streptozotocin‐induced diabetic rats. Effective extracts subjected isolation studies, structures compounds elucidated by spectroscopic methods. The ethyl acetate n ‐butanol had highest experiments. They also decreased aspartate transaminase, alanine transaminase malondialdehyde levels, increasing glutathione superoxide dismutase activity From active 11 phenolic characterized. Among quercetin was found be most according studies. provided scientific evidence for traditional use treating findings suggest that well quercetin, have potential development agents.

Language: Английский

Citations

6
Exploring antioxidant activities and inhibitory effects against α‐amylase and α‐glucosidase of Elaeocarpus braceanus fruits: insights into mechanisms by molecular docking and molecular dynamics DOI
Hong Li, Yuanyue Zhang, Zhijia Liu

et al.

International Journal of Food Science & Technology, Journal Year: 2023, Volume and Issue: 59(1), P. 343 - 355

Published: Nov. 3, 2023

Summary The present work investigated the antioxidant activity and inhibitory effects towards α‐amylase α‐glucosidase of phenolic compounds in Elaeocarpus braceanus fruits clarified their possible mechanisms based on molecular docking dynamic analysis. A total 12 were identified quantified extracts E. using UHPLC‐ESI‐HRMS/MS. TPC TFC 229.18 ± 5.76 mg GAE/g 144.85 1.17 RE/g, respectively. In vitro analyses, exhibited good activities demonstrated strong α‐glucosidase. Molecular dynamics results showed that quercetin myricetin can stably form hydrogen bonds van der Waals forces with active amino acid residues α‐glucosidase, thereby inhibiting enzymatic activities. findings might provide a potential natural resource for improving oxidative stress damage controlling blood glucose diabetes.

Language: Английский

Citations

5
Antidiabetic and antioxidant activities of the hydroalcoholic extracts of Canthium coromandelicum (Burm.f.) Alston leaf in Streptozotocin-induced diabetic rats DOI
Singamoorthy Amalraj,

J. Krupa,

David Raj Chellappan

et al.

Process Biochemistry, Journal Year: 2023, Volume and Issue: 137, P. 85 - 98

Published: Dec. 29, 2023

Language: Английский

Citations

5
Marine brown algae (Sargassum wightii) derived 9-hydroxyhexadecanoic acid: A promising inhibitor of α-amylase and α-glucosidase with mechanistic insights from molecular docking and its non-target toxicity analysis DOI
Paramasivam Deepak, Arun Meyyazhagan,

Nathiya Thiyagarajulu

et al.

South African Journal of Botany, Journal Year: 2023, Volume and Issue: 161, P. 627 - 637

Published: Sept. 1, 2023

Language: Английский

Citations

4
Argan: Phytochemical profiling and evaluation of the antioxidant, hypoglycemic, and antibacterial properties of its fruit pulp extracts DOI Creative Commons
A. Mdaghri Alaoui, Nihad Sahri, Ismail Mahdi

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23612 - e23612

Published: Dec. 12, 2023

Herein, we isolated three triterpenoid saponins from the methanol extract of fruit pulp argan

Language: Английский

Citations

4
Diversely Functionalized Benzopyran Scaffolds as Potential Lead Candidates for Treating Alzheimer's Disease and Diabetes DOI

Fouzia Naz,

Faiza Seraj,

Muhammad Taha

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140317 - 140317

Published: Oct. 9, 2024

Language: Английский

Citations

1
Dietary natural products as inhibitors of α-amylase and α-glucosidase: an updated review of ligand-receptor correlations validated by docking studies DOI
Maricruz Rangel‐Galván, Yesenia Pacheco‐Hernández, Edmundo Lozoya‐Gloria

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 62, P. 105456 - 105456

Published: Nov. 13, 2024

Language: Английский

Citations

1
In Vitro Analysis of Camellia sinensis Leaf Extract Against Diabetes Mellitus DOI Open Access

B. Venudevan and P. Srimathi,

R. Priyadharshini,

Selvaraj Jayaraman

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Introduction: Diabetes mellitus (DM) poses a significant global health challenge, with its prevalence steadily increasing. Natural compounds derived from plants have garnered attention for their potential therapeutic effects in managing this metabolic disorder. Camellia sinensis, commonly known as tea, is rich bioactive exhibiting various pharmacological properties. This study investigates the anti-diabetic activity of C. sinensis leaf extract through vitro analysis. Materials and methods: Camella was prepared by grinding plant's into powder, mixing it distilled water, heating. The antidiabetic assessed α-Amylase α-Glucosidase inhibitory assays, employing varying concentrations plant extract. Molecular docking analysis utilized Autodock 1.5.6 software (The Scripps Research Institute, California, US) to predict ligand-receptor interactions, guiding subsequent experimental validation. Result: exhibited high phenolic content, suggesting hyperglycemia. Tannins may aid glucose absorption inhibit adipogenesis, making them promising non-insulin-dependent DM (NIDDM). Terpenoids, antioxidant activity, advanced glycation. Saponins steroids were absent. revealed residues like IR, IRS1, AS160 impact on α-Glucosidase, comparable metformin. Conclusion: findings highlight hyperglycemia associated DM. content aids regulation. Specifically, presence tannins suggests role modulating inhibiting which could be particularly beneficial individuals NIDDM. These provide valuable insights molecular mechanisms underlying efficacy against DM, paving way further research development novel interventions diabetes management.

Language: Английский

Citations

0
Diversely Functionalized Benzopyran Scaffolds as Potential Lead Candidates for Treating Alzheimer's Disease and Diabetes DOI

Fouzia Naz,

Faiza Seraj,

Khalid M. Khan

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Antioxidants from Rubus idaeus leaves: LC-MS/MS chemical profiling, in vitro antiglycation, α-glucosidase and α-amylase inhibitory activities DOI

El Asri Sara,

Ben Mrid Reda,

Zakia Zouaoui

et al.

International Journal of Environmental Health Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 13

Published: Sept. 18, 2024

The present study evaluated a range of biological activities

Language: Английский

Citations

0