PLoS ONE,
Journal Year:
2024,
Volume and Issue:
19(12), P. e0316432 - e0316432
Published: Dec. 30, 2024
Lung
adenocarcinoma
(LUAD)
is
the
most
common
histological
subtype
of
lung
cancer,
characterized
by
a
high
incidence
in
late
stages,
mortality
rate,
and
poor
prognosis.
Src
Homology
2
Domain
Containing
Protein
5
(SH2D5)
mammalian-specific,
uncharacterized
scaffolding
protein,
its
role
LUAD
remains
unclear.
In
present
study,
we
investigated
function
potential
mechanisms
SH2D5
progression
LUAD.
We
found
aberrant
expression
tissues
cells,
closely
associated
with
prognosis
patients.
Through
loss-of-function
gain-of-function
experiments,
revealed
that
overexpression
promotes
proliferation
migration
abilities
cells.
Gene
set
enrichment
analysis
(GSEA)
positively
regulates
epithelial-mesenchymal
transition
(EMT)
process
Additionally,
regulating
influenced
phosphorylation
levels
AKT,
rescue
experiments
AKT
pathway
activators/inhibitors
partially
reversed
tumor
EMT
processes
induced
SH2D5.
summary,
our
study
demonstrated
cells
through
signaling
pathway,
suggesting
may
serve
as
crucial
target
for
treatment
metastatic
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14815 - 14815
Published: Oct. 1, 2023
The
epithelial–mesenchymal
transition
(EMT)
is
a
cellular
reprogramming
process
that
occurs
during
embryonic
development
and
adult
tissue
homeostasis.
This
involves
epithelial
cells
acquiring
mesenchymal
phenotype.
Through
EMT,
cancer
acquire
properties
associated
with
more
aggressive
EMT
its
opposite,
mesenchymal–epithelial
(MET),
have
been
described
in
tumors
over
the
past
ten
years,
including
colorectal
(CRC).
When
activated,
expression
of
marker
E-cadherin
decreased
vimentin
raised.
As
result,
temporarily
take
on
phenotype,
becoming
motile
promoting
spread
tumor
cells.
Epithelial–mesenchymal
plasticity
(EMP)
has
become
hot
issue
CRC
because
strong
inducers
(such
as
transforming
growth
factor
β,
TGF-β)
can
initiate
regulate
metastasis,
microenvironment,
immune
system
resistance
CRC.
In
this
review,
we
into
account
significance
EMT-MET
impact
cells’
prognosis
analysis
connection
between
stem
(CCSCs)
will
help
to
further
clarify
current
meager
understandings
EMT.
Recent
advances
affecting
important
transcription
factors
CCSCs
are
highlighted.
We
come
conclusion
regulatory
network
for
complicated,
great
deal
crosstalk
alternate
paths.
More
thorough
research
required
effectively
connect
clinical
management
biomarkers
targeted
treatments
Genes,
Journal Year:
2023,
Volume and Issue:
14(12), P. 2225 - 2225
Published: Dec. 16, 2023
Colon
cancer
(CRC)
is
a
prevalent
malignancy
that
exhibits
distinct
differences
in
incidence,
prognosis,
and
treatment
responses
between
males
females.
These
disparities
have
long
been
attributed
to
hormonal
differences,
particularly
the
influence
of
oestrogen
signalling.
This
review
aims
provide
comprehensive
analysis
recent
advances
our
understanding
molecular
mechanisms
underlying
sex
colon
protective
role
membrane
nuclear
signalling
CRC
development,
progression,
therapeutic
interventions.
We
discuss
epidemiological
evidence
supporting
cancer,
followed
by
an
exploration
impact
through
various
genomic
nongenomic
pathways
involving
receptors.
Furthermore,
we
examine
interplay
receptors
other
pathways,
particular
Wnt/β-catenin
proliferative
pathway
hypoxia
shaping
biological
actions
cancer.
Lastly,
highlight
potential
implications
targeting
management
propose
future
research
directions
address
current
gaps
this
complex
phenomenon.
Pharmacognosy Magazine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Background
Epithelial-mesenchymal
transition
(EMT)
is
crucial
in
liver
cancer
progression.
Developing
novel
medicines
to
disrupt
the
progression
of
EMT
might
be
a
approach
managing
cancer.
Purpose
This
study
investigates
protective
role
Astragalus
polysaccharide
(APS),
bioactive
compound
derived
from
membranaceus,
modulating
HepG2
cells.
Methods
The
effects
APS
on
were
evaluated
by
assessing
cell
viability,
proliferation,
invasion,
migration,
cycle,
and
apoptosis
Furthermore,
involvement
NOD-like
receptor
protein
3
(NLRP3)
inflammasome
this
process
was
explored.
Results
Results:
treatment
significantly
inhibited
migration
cells
while
promoting
cycle
arrest
apoptosis.
Notably,
reduced
expression
NLRP3
components,
including
NLRP3,
apoptosis-associated
speck-like
protein,
caspase-1,
decreasing
levels
inflammatory
cytokines.
In
addition,
activator
Nigericin
dampened
effect
partially
rescuing
activity
NLRP3.
Specifically,
promoted
development
exacerbated
malignant
transformation
improved
APS.
Conclusion
Our
findings
demonstrated
function
which
inhibits
activation
protect
results
showed
that
targeting
application
appears
viable
tactic
for
preventing
Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(5), P. 644 - 644
Published: March 6, 2025
Osteosarcoma
(OS)
is
the
most
common
primary
malignant
bone
tumor,
predominantly
affecting
children,
adolescents,
and
young
adults.
Epithelial-mesenchymal
transition
(EMT),
a
process
in
which
epithelial
cells
lose
their
cell-cell
adhesion
gain
migratory
invasive
properties,
has
been
extensively
studied
various
carcinomas.
However,
its
role
mesenchymal
tumors
like
osteosarcoma
remains
less
explored.
EMT
increasingly
recognized
as
key
factor
progression
of
osteosarcoma,
contributing
to
tumor
invasion,
metastasis,
resistance
chemotherapy.
This
narrative
review
aims
provide
comprehensive
overview
molecular
mechanisms
driving
highlighting
involvement
signaling
pathways
such
TGF-β,
transcription
factors
Snail,
Twist,
Zeb,
microRNAs
modulating
EMT.
Furthermore,
we
discuss
how
correlates
with
poor
prognosis
therapy
patients,
emphasizing
potential
targeting
for
therapeutic
intervention.
Recent
advancements
understanding
have
opened
new
avenues
treatment,
including
inhibitors
combination
therapies
aimed
at
overcoming
drug
resistance.
By
integrating
biological
insights
clinical
implications,
this
underscores
importance
critical
target.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Colorectal
cancer
(CRC)
is
a
highly
heterogeneous
tumor,
with
significant
variation
in
malignant
cells,
posing
challenges
for
treatment
and
prognosis.
However,
this
heterogeneity
offers
opportunities
personalized
therapy.
Methods
The
consensus
non-negative
matrix
factorization
algorithm
was
employed
to
analyze
single-cell
transcriptomic
data
from
CRC,
which
helped
identify
cell
expression
programs
(MCEPs).
Subsequently,
crosstalk
network
linking
MCEPs
immune/stromal
trajectory
development
constructed
using
Monocle3
NicheNet.
Additionally,
bulk
RNA-seq
were
utilized
systematically
explore
the
relationships
between
MCEPs,
clinical
features,
genetic
mutations.
A
prognostic
model
then
established
through
Lasso
Cox
regression
analyses,
integrating
into
nomogram
risk
prediction.
Furthermore,
key
genes
associated
their
potential
therapeutic
targets
identified
protein-protein
interaction
networks,
followed
by
molecular
docking
predict
drug-binding
affinity.
Results
We
classified
CRC
transcriptional
states
eight
distinct
successfully
networks
these
immune
or
stromal
cells.
containing
15
developed,
demonstrating
an
AUC
greater
than
0.8
evaluation
over
1
10
years
when
combined
features.
drug
target
gene
TIMP1
identified,
several
targeted
drugs
discovered.
Conclusion
This
study
demonstrated
that
characterization
of
could
effectively
reveal
biological
features
tumors
like
exhibit
tumor
prognosis
assessment.
Our
research
provides
new
theoretical
practical
directions
Annals of Medicine,
Journal Year:
2025,
Volume and Issue:
57(1)
Published: March 31, 2025
Background:
After
glucagon
and
insulin,
amylin
is
the
third
most
significant
active
islet
hormone.
Amylin
insulin
act
synergistically
to
suppress
postprandial
blood
glucose
levels.
Research
has
shown
that
plays
a
vital
role
in
growth
progression
of
cancer;
however,
relationship
between
gastric
cancer
(GC)
unclear.
