Cited by Treatment-induced ripple effect: a systematic review exploring the abscopal phenomenon in Glioblastoma multiforme

Advances in dendritic cell vaccination therapy of cancer DOI

Sajad Najafi, Keywan Mortezaee

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114954 - 114954

Published: May 29, 2023

Traditionally, vaccines have helped eradication of several infectious diseases and also saved millions lives in the human history. Those prophylactic acted through inducing immune responses against a live attenuated, killed organism or antigenic subunits to protect recipient real infection caused by pathogenic microorganism. Nevertheless, development anticancer as valuable targets health has faced challenges requires further optimizations. Dendritic cells (DCs) are most potent antigen presenting (APCs) that play essential roles tumor immunotherapies induction CD8+ T cell immunity. Accordingly, various strategies been tested employ DCs therapeutic for exploiting their activity cells. Application whole purified/recombinant peptides common approaches pulsing DCs, which then injected back into patients. Although some hopeful results reported number DC animal clinical trials cancer patients, such still inefficient require optimization. Failure vaccination is postulated due immunosuppressive microenvironment (TME), overexpression checkpoint proteins, suboptimal avidity tumor-associated (TAA)-specific lymphocytes, lack appropriate adjuvants. In this review, we an overview current experiments evaluated efficacy well focusing on improve potential including combination therapy with inhibitors (ICIs).

Language: Английский

Citations

Modifying CAR-T cells with anti-checkpoints in cancer immunotherapy: A focus on anti PD-1/PD-L1 antibodies DOI

Sajad Najafi, Keywan Mortezaee

Life Sciences, Journal Year: 2023, Volume and Issue: 338, P. 122387 - 122387

Published: Dec. 26, 2023

Language: Английский

Citations

The significance of chemical transfection/transduction enhancers in promoting the viral vectors-assisted gene delivery approaches: A focus on potentials for inherited retinal diseases DOI