International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9692 - 9692
Published: Sept. 7, 2024
Doxorubicin
(DOX)
is
a
potent
chemotherapeutic
agent
with
well-documented
dose-dependent
cardiotoxicity.
Regular
exercise
recognized
for
its
cardioprotective
effects
against
DOX-induced
cardiac
inflammation,
although
the
precise
mechanisms
remain
incompletely
understood.
The
activation
of
inflammasomes
has
been
implicated
in
pathogenesis
and
treatment
cardiotoxicity,
nucleotide-binding
domain-like
receptor
protein
3
(NLRP3)
inflammasome
emerging
as
key
mediator
cardiovascular
inflammation.
This
study
aimed
to
investigate
role
modulating
NLRP3
protect
Male
Sprague–Dawley
rats
were
randomly
assigned
receive
10-day
course
DOX
or
saline
injections,
without
preceding
10-week
treadmill
running
regimen.
Cardiovascular
function
histological
changes
subsequently
evaluated.
cardiotoxicity
was
characterized
by
atrophy,
systolic
dysfunction,
hypotension,
alongside
inflammasome.
Our
findings
revealed
that
regular
preserved
mass
hypertrophic
indices
prevented
it
did
not
fully
preserve
blood
pressure.
These
results
underscore
significant
While
entirely
prevent
our
demonstrate
confers
protection
suppressing
heart,
underscoring
anti-inflammatory
role.
Further
research
should
explore
temporal
dynamics
interactions
among
exercise,
pyroptosis,
other
pathways
enhance
translational
applications
medicine.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1706 - 1706
Published: April 27, 2024
FAM46C
is
a
well-established
tumour
suppressor
with
role
that
not
completely
defined
or
universally
accepted.
Although
expression
down-modulated
in
several
tumours,
significant
mutations
the
gene
are
only
found
multiple
myeloma
(MM).
Consequently,
its
activity
has
primarily
been
studied
MM
context.
However,
emerging
evidence
suggests
involved
also
other
cancer
types,
namely
colorectal,
prostate
and
gastric
squamous
cell
hepatocellular
carcinoma,
where
was
to
be
significantly
reduced
tumoural
versus
non-tumoural
tissues
shown
possess
anti-proliferative
properties.
Accordingly,
recently
proposed
function
as
pan-cancer
prognostic
marker,
bringing
under
spotlight
attracting
growing
interest
from
scientific
community
pathways
modulated
by
mechanistic
activity.
Here,
we
will
provide
first
comprehensive
review
regarding
covering
(1)
intracellular
regulated
FAM46C,
MAPK/ERK,
PI3K/AKT,
β-catenin
TGF-β/SMAD
pathways;
(2)
models
mode
of
action,
specifically
poly(A)
polymerase,
trafficking
modulator
inhibitor
centriole
duplication
models,
focusing
on
connections
interdependencies;
(3)
regulation
different
environments
interferons,
IL-4,
TLR
engagement
transcriptional
modulators;
and,
lastly,
(4)
how
levels
associate
increased/decreased
sensitivity
anticancer
agents,
such
bortezomib,
dexamethasone,
lenalidomide,
pomalidomide,
doxorubicin,
melphalan,
SK1-I,
docetaxel
norcantharidin.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(4), P. 277 - 277
Published: April 5, 2025
Doxorubicin
(DOX)
is
used
for
the
treatment
of
various
malignancies,
including
leukemias,
lymphomas,
sarcomas,
and
bladder,
breast,
gynecological
cancers
in
adults,
adolescents,
children.
However,
DOX
causes
severe
side
effects
patients,
such
as
cardiotoxicity,
which
encompasses
heart
failure,
arrhythmia,
myocardial
infarction.
DOX-induced
cardiotoxicity
(DIC)
based
on
combination
nuclear-mediated
cardiomyocyte
death
mitochondrial-mediated
death.
Oxidative
stress,
altered
autophagy,
inflammation,
apoptosis/ferroptosis
represent
main
pathogenetic
mechanisms
responsible
DIC.
In
addition,
vitro
vivo
models
DIC
sirtuins
(SIRT),
especially,
SIRT
1
are
reduced,
this
event
contributes
to
cardiac
damage.
fact,
inhibits
reactive
oxygen
species
NF-kB
activation,
thus
improving
oxidative
stress
remodeling.
Therefore,
recovery
during
may
a
therapeutic
strategy
limit
progression.
Natural
products,
i.e.,
polyphenols,
well
nano
formulations
iron
chelators,
other
potential
compounds
experimented
with
At
present,
few
clinical
trials
available
confirm
efficacy
these
products
The
aim
review
description
pathophysiology
drug
targets
alleviate
Translational Research in Anatomy,
Journal Year:
2024,
Volume and Issue:
36, P. 100304 - 100304
Published: May 5, 2024
The
development
of
the
cardiovascular
system
is
a
highly
intricate
process
that
encompasses
various
types
cells
and
communication
pathways.
During
embryonic
development,
specific
differentiate
organize
to
form
complex
structures
heart
blood
vessels.
An
important
group
involved
in
this
called
cardiac
neural
crest
cells.
These
originate
from
dorsal
tube
migrate
circumpharyngeal
ridge,
pharyngeal
arches
3-6,
invade
developing
through
outflow
tract.
Once
they
reach
their
destination,
contribute
formation
system.
include
aortic
arch
arteries,
aorticopulmonary
septum,
valves,
conduction
system,
cardiomyocytes,
smooth
muscle
found
middle
layers
arteries.
Disruptions
migration,
proliferation,
or
differentiation
during
as
seen
conditions
such
DiGeorge
syndrome,
can
lead
variety
congenital
defects.
defects
encompass
wide
range
abnormalities,
including
Tetralogy
Fallot,
tract
persistent
truncus
arteriosus,
double
outlet
right
ventricle,
interrupted
arch,
ventricular
septal
defects,
abnormalities
well
function
semilunar
myocardium,
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 5, 2024
Introduction
Studies
on
the
use
of
direct
oral
anticoagulants
(DOACs)
for
preventing
venous
thromboembolism
(VTE)
in
hospitalized
cancer
patients
are
lacking.
Therefore,
we
conducted
a
multicenter
retrospective
cohort
study
to
evaluate
efficacy
and
safety
DOACs
versus
low-molecular-weight
heparin
(LMWH)
primary
prevention
VTE
patients.
Methods
Clinical
outcomes
included
thrombosis,
VTE,
other
all
bleeding,
major
nonmajor
all-cause
death.
A
1:1
rivaroxaban
LMWH
was
created
by
propensity
score
matching.
Results
total
2,385
were
this
study.
During
3-month
follow-up
period,
129
(5.4%)
thrombosis
events
occurred,
63
(2.7%)
which
VTEs
66
(2.8%)
events.
All
bleeding
occurred
163
(6.8%)
patients,
68
(2.9%)
had
95
(4.0%)
bleeding.
All-cause
deaths
113
(4.7%)
After
adjusting
various
confounders,
incidence
thromboses
significantly
lower
group
than
[OR
0.543,
95%
CI
(0.343–0.859),
p
=
0.009;
OR
0.461,
(0.241–0.883),
0.020].
There
no
significant
differences
or
Conclusion
In
oncology
receiving
thromboprophylaxis,
has
similar
as
does
not
increase
risk
Rivaroxaban
may
be
an
attractive
alternative
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9735 - 9735
Published: Sept. 9, 2024
Doxorubicin
(DOX),
a
commonly
used
anticancer
agent,
causes
cardiotoxicity
that
begins
with
the
first
dose
and
may
progress
to
heart
failure
years
after
treatment.
An
inflammatory
response
associated
neutrophil
recruitment
has
been
recognized
as
mechanism
of
DOX-induced
cardiotoxicity.
This
study
aimed
validate
mRNA
expression
previously
identified
biomarkers
cardiotoxicity,
PGLYRP1,
CAMP,
MMP9,
CEACAM8,
assay
their
protein
in
peripheral
blood
breast
cancer
patients.
Blood
samples
from
40
patients
treated
DOX-based
chemotherapy
were
collected
before
cycle
>
2
The
gene
PGLYRP1/Tag7,
CAMP/LL37,
MMP9/gelatinase
B,
CEACAM8/CD66b
determined
using
ELISA
reverse
transcription-quantitative
polymerase
chain
reaction
(RT-qPCR).
Receiver
operating
characteristic
(ROC)
curve
analysis
was
determine
diagnostic
value
each
candidate
biomarker.
Patients
(n
=
20)
had
significantly
elevated
levels
CEACAM8
at
baseline,
chemotherapy,
treatment
relative
without
20).
DOX
induced
higher
all
examined
both
groups
At
post
treatment,
but
MMP9
dropped
below
baseline.
There
good
correlation
between
target
proteins.
We
demonstrate
circulating
can
predict
DOX.
novel
finding
be
early
identification
risk
for
