Progress of Nanomaterials Based on Manganese Dioxide in the Field of Tumor Diagnosis and Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8883 - 8900

Published: Aug. 1, 2024

As a pivotal transition metal oxide, manganese dioxide (MnO

---

Calcium Fluoride/Manganese Dioxide Nanocomposite with Dual Enzyme-like Activities for Uric Acid Sensing: A Comparative Study of Enzyme and Nonenzyme Methods

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 16(1), P. 54 - 65

Published: Dec. 20, 2023

The debate over enzyme methods versus nonenzyme in the field of nanosensing has lasted for decades despite hundreds published studies on this topic. In study, we first present a comparative analysis these using reaction based CaF2/MnO2 nanocomposite (CM Nc) with dual–enzyme activity, presenting oxidase- and peroxidase-like activities. Uric acid (UA) is byproduct purine metabolism body, abnormal levels can cause many diseases; hence, tracking amount UA human serum crucial. method was established uricase CM Nc: produced H2O2 when catalyzed by uricase; then into reactive oxygen species (ROS) peroxidase activity Nc; ROS oxidized 3,3′,5,5′-tetramethylbenzidine (TMB), which blue TMB (oxTMB). built scavenging effect ROS, prevented catalytic capability Nc toward induced oxTMB fading. results further tests revealed good selectivity compared to fast response method. Additionally, both were effective determining concentration serum. two separate also independently verify each other, increasing accuracy detection accordance relatively independent principles. This research provided theoretical backing practical design multienzyme nanozyme catalysts, facilitate precise biochemical products.

Language: Английский

---

Construction of a colorimetric sensor array for the identification of phenolic compounds by the laccase-like activity of N-doped manganese oxide

Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125324 - 125324

Published: Nov. 4, 2023

Language: Английский

---

A novel dual-function biomimetic approach for high throughput organic dye biodegradation and hydrogen peroxide sensing using a nanosized artificial peroxidase with ultra-improved substrate affinity and superb catalytic efficiency

Process Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

---

A Dual-Mode Sensing System Based on Carbon Dots and Mno2 Nanosheets with Peroxidase-Like Activity for the Detection of Alkaline Phosphatase and its Inhibitors

Published: Jan. 1, 2025

Language: Английский

---

A Dual-Mode Sensing System Based on Carbon Dots and Mno2 Nanosheets with Peroxidase-Like Activity for the Detection of Alkaline Phosphatase and its Inhibitors

Published: Jan. 1, 2025

Language: Английский

---

Photothermal-Controlled Microneedle for Transdermal Delivery of Metal-Phenolic Nanozyme with Staged Multifunctions to Accelerate Healing of Infected Diabetic Wounds

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101554 - 101554

Published: Feb. 4, 2025

Conventional wound dressings for infected diabetic wounds (IDWs) typically target only the surface, often neglecting need multifunctional therapies that address deeper tissue layers, resulting in less effective treatment outcomes. Emerging research suggests a comprehensive approach to IDW therapy should involve transdermal delivery of therapeutic agents capable staged bacterial eradication, reactive oxygen species (ROS) scavenging, and angiogenesis. This study introduces novel metal-phenolic nanozyme, CuTA@MnO2 nanoflake, designed therapy. The nanozyme is synthesized by loading copper ions (Cu2+) onto manganese dioxide (MnO2) via in-situ polymerization, with tannic acid (TA) as linker, encapsulated hyaluronic (HA) solution form photothermally controlled microneedle system. In rat model, this system effectively delivered photothermal therapy, eliminating bacteria under 808 nm near-infrared light. heat-induced HA degradation released where MnO2 TA reduced ROS levels, providing antioxidant effects. Concurrently, Cu2+ promoted angiogenesis, significantly accelerating healing. Whole transcriptome RNA sequencing confirmed enhanced angiogenesis collagen remodeling, along inflammation. offers promising platform IDWs through oxidant promotion.

Language: Английский

---

Precision therapeutics for inflammatory bowel disease: advancing ROS-responsive nanoparticles for targeted and multifunctional drug delivery

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: 13(10), P. 3245 - 3269

Published: Jan. 1, 2025

This review discusses ROS-responsive nanoparticles in IBD therapy, highlighting challenges, solutions, and the “layered programmable delivery” strategy for enhanced drug delivery localized treatment.

Language: Английский

---

Dissolving Microneedles as In Situ Chemical Reaction Chambers: from Design Strategies to Versatile Biomedical Applications

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.

Language: Английский

---

Multifunctional nanozymatic biosensors: awareness, regulation and pathogenic bacteria detection - a review

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 127957 - 127957

Published: March 1, 2025

Language: Английский

---