Association study between intestinal flora and renal malignancy based on genome-wide association analysis data DOI Creative Commons

Jingzheng Gan,

Yuan Yuan, Xiong Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

Abstract Objective Gut microbiome (GM) plays an important role in a variety of diseases, and renal malignancies have been shown to be closely associated with GM. However, the GM pathogenesis has not fully explored. The aim this study was investigate potential causal association between intestinal flora possible mechanisms action. Methods We collected genome-wide (GWAS) data on applied Mendelian randomization (MR) analysis explore them. Results By MR analysis, we found that components malignancies, including enterobacteria certain orders, families, genera, may negative effects pathogenesis, while other genera positive associations malignancies. Conclusion This reveals identifies several genetic variants involved association. These findings are expected provide new insights into theoretical basis for development therapeutic strategies targeting future.

Language: Английский

Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy DOI Creative Commons

Shan Lu,

Chunling Wang,

Jingru Ma

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

The human microbiome has recently emerged as a focal point in cancer research, specifically anti-tumor immunity, immunotherapy, and chemotherapy. This review explores microbial-derived metabolites, emphasizing their crucial roles shaping fundamental aspects of treatment. Metabolites such short-chain fatty acids (SCFAs), Trimethylamine N-Oxide (TMAO), Tryptophan take the spotlight, underscoring diverse origins functions profound impact on host immune system. focus is SCFAs’ remarkable ability to modulate responses, reduce inflammation, enhance immunity within intricate tumor microenvironment (TME). critically evaluates TMAO, intricately tied dietary choices gut microbiota composition, assessing its implications for susceptibility, progression, immunosuppression. Additionally, involvement tryptophan other amino acid metabolites responses discussed, highlighting influence checkpoints, immunosuppression, immunotherapy effectiveness. examination extends dynamic interaction with chemotherapy, potential alter treatment protocols optimize outcomes patients. A comprehensive understanding role therapy attained by exploring impacts drug metabolism, therapeutic resistance development. In conclusion, this underscores pivotal contributions regulating chemotherapy outcomes. By illuminating interactions between these therapy, article enhances our biology, paving way development more effective options ongoing battle against cancer.

Language: Английский

Citations

1
Study of Microbiota Associated to Early Tumors Can Shed Light on Colon Carcinogenesis DOI Open Access
Anna Aspesi, Marta La Vecchia,

G. Sala

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13308 - 13308

Published: Dec. 11, 2024

An increasingly important role for gut microbiota in the initiation and progression of colorectal cancer (CRC) has been described. Even early stages transformation, i.e., adenomas, changes composition have observed, several bacterial species, such as pks+ Escherichia coli enterotoxigenic Bacteroides fragilis, proposed to drive colon tumorigenesis. In recent years, strategies developed study mucosa-associated (MAM), which is more closely associated with CRC development than lumen-associated (LAM) derived from fecal samples. This review summarizes state art about oncogenic actions bacteria compares different sampling collect intestinal (feces, biopsies, swabs, brushes, washing aspirates). particular, this article recapitulates current knowledge on MAM adenomas serrated polyps, since studying early-stage tumors can elucidate molecular mechanisms underpinning carcinogenesis.

Language: Английский

Citations

1
Hidden army within: Harnessing the microbiome to improve cancer treatment outcomes DOI
Ippokratis Messaritakis, G Vougiouklakis,

Asimina Koulouridi

et al.

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(28), P. 6159 - 6164

Published: Aug. 13, 2024

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment response. Dysbiosis, an imbalance the microbial community, impacts tumor initiation, progression, therapy outcomes. Specific bacterial species have been associated with either promoting or inhibiting growth, offering potential targets for therapeutic intervention. influences efficacy toxicity of conventional treatments cutting-edge immunotherapies, highlighting its target care. However, translating research into clinical practice requires addressing challenges such standardizing methodologies, validating biomarkers, ensuring ethical considerations. Here, we provide comprehensive overview microbiome's role need ongoing research, collaboration, innovation to harness full improving patient outcomes oncology. current editorial aims explore these insights emphasizes standardized validation interdisciplinary collaboration translate applications. Furthermore, it underscores considerations regulatory surrounding use microbiome-based therapies. Together, this article advocates realize microbiome-guided oncology care

Language: Английский

Citations

0
THE ROLE OF GUT MICROBIOTA IN IMMUNOMODULATION AND AUTOIMMUNE DISEASES: A COMPREHENSIVE REVIEW DOI Open Access
Olaa Moyad Ali

International Journal of Medical Science and Dental Health, Journal Year: 2023, Volume and Issue: 09(12), P. 47 - 61

Published: Dec. 24, 2023

The investigation into autoimmune conditions, particularly the intricate interplay between gut microbiome and immune response, has emerged as a critical domain of scholarly scrutiny. This review article provides comprehensive analysis prevailing views on role microbiota in regulation development diseases. We begin this study by explaining basic interactions microorganisms their relationship with system. then discuss dysbacteriosis its implications for dysfunction, thus understanding initiation reactions. Next, we delve section examining reviewing clinical research findings identifying associations differences microbial compositions various diseases such inflammatory bowel disease, rheumatoid arthritis, type 1 diabetes. In conclusion, addresses methodological challenges that currently impede progress field suggests approaches plans future may advance our played prevention, diagnosis, treatment emphasizes need to combine strategies improve patient prognosis cases

Language: Английский

Citations

1
Association study between intestinal flora and renal malignancy based on genome-wide association analysis data DOI Creative Commons

Jingzheng Gan,

Yuan Yuan, Xiong Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

Abstract Objective Gut microbiome (GM) plays an important role in a variety of diseases, and renal malignancies have been shown to be closely associated with GM. However, the GM pathogenesis has not fully explored. The aim this study was investigate potential causal association between intestinal flora possible mechanisms action. Methods We collected genome-wide (GWAS) data on applied Mendelian randomization (MR) analysis explore them. Results By MR analysis, we found that components malignancies, including enterobacteria certain orders, families, genera, may negative effects pathogenesis, while other genera positive associations malignancies. Conclusion This reveals identifies several genetic variants involved association. These findings are expected provide new insights into theoretical basis for development therapeutic strategies targeting future.

Language: Английский

Citations

0