Journal of Hepatocellular Carcinoma,
Journal Year:
2023,
Volume and Issue:
Volume 10, P. 2197 - 2209
Published: Dec. 1, 2023
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
serious
malignant
tumors
threatening
human
life
with
a
high
mortality
rate.
The
liver
regenerative
capacity
after
hepatectomy
in
early-stage
HCC
patients
influenced
by
various
factors,
including
surgical
methods
and
energy
metabolism.
This
study
aims
to
provide
prognostic
model
based
on
genes
related
regeneration
that
can
predict
prognosis
non-tumor
tissues
patients.A
total
584
from
were
collected
three
independent
databases.
Kaplan-Meier
survival
curves
used
identify
liver-regeneration
genes.
Subsequently,
indicator,
designated
as
Liver
Regeneration
score
(LR
score),
was
determined
using
single-sample
gene
set
enrichment
analysis
(ssGSEA).
Independent
cohorts
verify
relationship
between
LR
patients.
Furthermore,
regeneration-related
established
validate
key
identified
through
LASSO
Cox
regression
analysis.We
constructed
comprising
24
genes,
utilized
its
levels
tissues.
In
patients,
higher
scores
associated
improved
prognosis.
Higher
indicate
metabolism
revealed
Enrichment
analysis.
two
DHTKD1
(dehydrogenase
E1
transketolase
domain
containing
1)
PHYH
(phytanoyl-CoA
2-hydroxylase),
expression
these
correlated
better
also
changed
corresponding
progression
regeneration.In
summary,
our
has
introduced
novel
signature
for
providing
predictive
estimating
clinical
demonstrates
promise
reliable
indicator
predicting
overall
HCC.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: Feb. 17, 2025
As
cancer
incidence
and
mortality
rates
rise,
there
is
an
urgent
need
to
develop
effective
immunotherapy
strategies.
Circular
RNA
(circRNA),
a
newly
identified
type
of
non-coding
RNA,
abundant
within
cells
can
be
released
via
exosomes,
facilitating
communication
between
cells.
Studies
have
demonstrated
that
exosomal
circRNAs
alter
the
tumor
microenvironment
modulate
immune
responses
by
influencing
functions
T
cells,
natural
killer
(NK)
macrophages,
thereby
enabling
tumors
evade
system.
Moreover,
show
potential
as
diagnostic
biomarkers
therapeutic
targets
for
cancer.
This
review
summarizes
regulatory
roles
in
their
applications
progression
treatment,
highlighting
promise
improving
immunotherapy.
Future
research
should
concentrate
on
understanding
mechanisms
key
developing
targeted
methods.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7275 - 7275
Published: July 2, 2024
The
RNA
world
is
wide,
and
besides
mRNA,
there
a
variety
of
other
types,
such
as
non-coding
(nc)RNAs,
which
harbor
various
intracellular
regulatory
functions.
This
review
focuses
on
small
interfering
(si)RNA
micro
(mi)RNA,
form
complex
network
regulating
mRNA
translation
and,
consequently,
gene
expression.
In
fact,
these
RNAs
are
critically
involved
in
the
function
phenotype
all
cells
human
body,
including
malignant
cells.
cancer,
two
main
targets
for
therapy
dysregulated
cancer
dysfunctional
immune
To
exploit
potential
mi-
or
siRNA
therapeutics
therapy,
profound
understanding
mechanisms
following
targeted
intervention
needed
to
re-program
cell
functions
vivo.
first
part
less
well-known
RNAs,
miRNA,
presents
RNA-based
technologies.
second
part,
therapeutic
technologies
treating
discussed,
with
particular
attention
manipulating
tumor-associated
cells,
especially
myeloid
Frontiers in Genetics,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 3, 2025
Relationships
between
cellular
senescence
and
gastrointestinal
cancers
have
gained
prominence
in
recent
years.
The
currently
accepted
theory
suggests
that
cancer
occurrence
exhibit
"double-edged
sword"
effects.
Cellular
is
related
to
via
four
"meta-hallmarks"
i.e.,
genomic
instability,
epigenetic
alterations,
chronic
inflammation,
dysbiosis,
along
with
two
"antagonistic
hallmarks"
telomere
attrition
stem
cell
exhaustion.
These
relationships
are
characterized
by
both
agonistic
antagonistic
elements,
but
the
existence
of
an
intricate
dynamic
balance
remains
unknown.
Non-coding
RNAs
(ncRNAs)
vital
roles
post-transcriptional
regulation,
how
they
participate
be
fully
investigated.
In
this
article,
we
systematically
review
ncRNAs
(including
microRNAs
(miRNAs),
long
(lncRNAs),
circularRNAs
(circRNAs))
interactions
cancers.
Our
aim
elucidate
a
triangular
relationship
"ncRNAs-senescence-gastrointestinal
cancers"
which
considered
these
three
elements
as
equal
important
standing.
We
keen
identify
prognostic
or
therapeutic
targets
for
from,
aging-related
ncRNAs,
discover
novel
strategies
treat
manage
elderly.
seek
clarify
complex
where
"senescence-gastrointestinal
interactions.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 19, 2025
Abstract
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
solid
malignancies
in
world.
Due
to
limited
effectiveness
current
drug
treatments,
further
research
on
HCC
necessary.
PANoptosis
defined
as
an
inflammatory
RCD
whose
main
features
combine
pyroptosis,
apoptosis
and
necroptosis
which
cannot
be
explained
by
any
these
three
RCDs
alone.
In
HCC,
risk
stratification
based
PANoptosis-associated
lncRNAs
has
clinical
application
potential.
this
study,
we
explored
related
PANoptosis-related
(PRLs)
analyzing
significantly
differentially
expressed
genes
HCC.
HCC-associated
PRL
scores
were
established
WGCNA,
LASSO
analysis
multivariate
Cox
assessment.
Subsequently,
verified
prognostic
ability
score
for
patients,
basis
a
assessment
model
its
reliability.
The
relationship
between
immune
infiltration
well
sensitivity
was
analyzed
evaluate
reference
value
model.
Western
blot
PCR
reliability
bioinformatics
results.
observed
suppression
progression
invasiveness
following
selected
knockdown
validated
our
Our
results
provide
new
evidence
role
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(3), P. 1737 - 1737
Published: Feb. 1, 2024
The
advent
of
immune
checkpoint
inhibitors
(ICIs)
has
represented
a
breakthrough
in
the
treatment
many
cancers,
although
high
number
patients
fail
to
respond
ICIs,
which
is
partially
due
ability
tumor
cells
evade
system
surveillance.
Non-coding
microRNAs
(miRNAs)
have
been
shown
modulate
evasion
cells,
and
there
thus
growing
interest
elucidating
whether
these
miRNAs
could
be
targetable
or
proposed
as
novel
biomarkers
for
prognosis
response
ICIs.
We
therefore
performed
an
extensive
literature
analysis
evaluate
clinical
utility
with
confirmed
direct
relationship
As
result
this
systematic
review,
we
stratified
miRNA
landscape
into
(i)
whose
levels
directly
(ii)
expression
modulated
by
(iii)
that
elicit
toxic
effects
participate
immune-related
adverse
events
(irAEs)
caused
Cancers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 766 - 766
Published: Feb. 13, 2024
The
incidence
of
hepatocellular
carcinoma
(HCC)
is
increasing,
and
40%
patients
are
diagnosed
at
advanced
stages.
Over
the
past
5
years,
number
clinically
available
treatments
has
dramatically
increased
for
HCC,
making
patient
management
particularly
complex.
Immune
checkpoint
inhibitors
(ICIs)
have
improved
overall
survival
patients,
showing
a
durable
treatment
benefit
over
time
different
response
pattern
with
respect
to
tyrosine
kinase
(TKIs).
Although
there
in
responder
cases,
sizeable
group
primary
progressors
or
ineligible
immunotherapy.
Indeed,
nonviral
etiologies,
such
as
nonalcoholic
steatohepatitis
(NASH),
alterations
specific
driver
genes
might
be
less
responsive
Therefore,
improving
comprehension
mechanisms
drug
resistance
identifying
biomarkers
that
informative
best
approach
required
actions
improve
survival.
Abundant
evidence
indicates
noncoding
RNAs
(ncRNAs)
pivotal
players
cancer.
Molecular
through
which
ncRNAs
exert
their
effects
cancer
progression
been
widely
investigated.
Nevertheless,
no
studies
summarizing
synergistic
effect
between
ncRNA-based
strategies
TKIs
ICIs
preclinical
setting.
This
review
aims
provide
up-to-date
information
regarding
possible
use
therapeutic
targets
association
molecular-targeted
agents
immunotherapies
predictive
tools
selection
optimized
options
HCCs.
