Association between systemic sclerosis and risk of cerebrovascular and cardiovascular disease: a meta-analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 18, 2024

Abstract We aimed to evaluate the association between systemic sclerosis (SSc) and major cerebrovascular/cardiovascular risks through a systematic approach. Databases were systematically searched from their inception October 10, 2023 for studies comparing event rates patients with SSc controls. The primary outcome was stroke risk in SSc. Secondary outcomes included of myocardial infarction (MI), cardiovascular disease (CVD), peripheral vascular (PVD), venous thromboembolism (VTE). Seventeen 6,642,297 participants included. associated significantly increased (HR, 1.64; 95% confidence interval [CI], 1.35–2.01), CVD 2.12; CI, 1.36–3.3), MI 2.15; 1.23–3.77), VTE 2.75; 1.77–4.28), PVD 5.23; 4.25–6.45). Subgroup analysis revealed non-Asian group 1.55; 1.26–1.9), while Asian displayed higher but not statistically significant 1.86; 0.97–3.55). study found that is events. These findings highlight importance vasculopathy suggest need enhanced clinical monitoring preventive measures this high-risk population.

Language: Английский

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Residual Traditional Risk in Non-Traditional Atherosclerotic Diseases

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 535 - 535

Published: Jan. 10, 2025

Individuals with chronic inflammatory and immune disorders are at an increased risk of atherosclerotic events premature cardiovascular (CV) disease. Despite extensive literature exploring the relationship between "non-traditional" conditions CV risk, many aspects remain unresolved, including underlying mechanisms promoting "non-traditional risk", development innovative comprehensive assessment tool, recommendations for tailored interventions. This review aims to evaluate available evidence on key risk-enhancer conditions, a focus assessing managing factors. We conducted 412 original articles, narrative systematic reviews, meta-analyses addressing associated conditions. The analysis examined these relationships identified strategies mitigating elevated risk. A major challenge highlighted is difficulty in quantifying contribution individual factors disease-specific elements While supports benefits statins beyond lipid lowering, such as pleiotropic endothelial effects, current guidelines lack specific use or other therapies targeting non-traditional Additionally, absence validated scores that incorporate hinders accurate evaluation management. growing prevalence conditions" underscores need improved awareness thorough understanding all contributing factors, elements, crucial prediction disease (CVD) represents essential foundation informed decision-making primary secondary prevention. advocate future research developing innovative, tools recognizing this promising avenue translational clinical outcome research.

Language: Английский

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Aberrant lipid profiles and lymphocyte counts in systemic sclerosis population, reassessing predictive value for concurrent cardiovascular diseases

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

To investigate alterations in blood lipid profiles and T cell subsets among systemic sclerosis (SSc) patients, to assess their potential utility predicting cardiovascular disease (CVD) risk. 105 SSc patients 80 age- sex-matched healthy controls (HCs) were enrolled. Flow cytometry was employed quantify subsets. Multivariate logistic regression analysis investigated the association between profile, subsets, occurrence, CVD Additionally, a prediction model developed predictive value of In low-density lipoprotein cholesterol (LDL-C) (OR = 3.212, 95%CI 1.132-9.113, p= 0.028), ESR 1.218, 1.086-1.367, 0.001), CRP 2.156, 95% CI 1.393-3.338, p helper (Th)cells 1.004, 1.001-1.008, 0.034) positively correlated with risk SSc. Further studies found that absolute increases Th cells associated (OR=1.002, 95%CI=1.001-1.005, =0.011) independent predictors When exceeded 866.53 cells/μL, greatly increased (p<0.001). Altered dysregulated expression significant elevation specifically noted SSc-CVD suggesting may serve as biomarker for thereby aiding early diagnosis. The underlying mechanism this requires further investigation.

Language: Английский

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Efficacy and safety of platelet-rich plasma therapy in systemic sclerosis and localized scleroderma; a systematic review

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Feb. 27, 2025

Language: Английский

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A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathways

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Systemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology characterized by the development frequently progressive cutaneous and internal organ fibrosis accompanied severe vascular alterations. The pathogenesis SSc highly complex and, despite extensive investigation, has not been fully elucidated. Numerous studies have suggested that etiologic factors cause multiple alterations in genetically receptive hosts, leading to progression. These events may be functionally pathologically interconnected include: 1) Structural functional microvascular endothelial cell abnormalities; 2) Severe oxidative stress high reactive oxygen species (3); Frequently visceral fibrosis; 4) Transdifferentiation various types into activated myofibroblasts, cells ultimately responsible for fibrotic process; 5) Establishment chronic inflammatory process affected tissues; 6) Release cytokines, chemokines, growth from cells; 7) Abnormalities humoral cellular immunity with production specific autoantibodies; 8) Epigenetic including changes non-coding RNAs. manifest different levels intensity organs display remarkable individual variability, resulting wide heterogeneity extent severity clinical manifestations. Here, we will review some recent related pathogenesis.

Language: Английский

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The role of hypoxic microenvironment in autoimmune diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs). Central to this process is hypoxia-inducible factor-1 (HIF-1), which orchestrates wide array cellular responses under low conditions. This review delves into multifaceted roles microenvironment modulating immune cell function, particularly highlighting its impact on activation, metabolic reprogramming, angiogenesis. Specific focus given mechanisms hypoxia contributes development exacerbation such rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), dermatomyositis (DM). In these conditions, not only disrupts tolerance but also enhances inflammatory promotes tissue damage. discusses emerging therapeutic strategies aimed at targeting pathways, including application HIF-1α inhibitors, mTOR other modulators response. By providing comprehensive overview interplay between dysfunction AIDs, offers new perspectives underlying highlights potential avenues for intervention.

Language: Английский

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Theoretical Studies of DNA Microarray Present Potential Molecular and Cellular Interconnectivity of Signaling Pathways in Immune System Dysregulation

Genes, Journal Year: 2024, Volume and Issue: 15(4), P. 393 - 393

Published: March 22, 2024

Autoimmunity is defined as the inability to regulate immunological activities in body, especially response external triggers, leading attack of tissues and organs host. Outcomes include onset autoimmune diseases whose effects are primarily due dysregulated immune responses. In past years, there have been cases that show an increased susceptibility other disorders patients who already experiencing same type disease. Research this field has started analyzing potential molecular cellular causes interconnectedness, bearing mind possibility advancing drugs therapies for treatment autoimmunity. With that, study aimed determine correlation four diseases, which 1 diabetes (T1D), psoriasis (PSR), systemic sclerosis (SSc), lupus erythematosus (SLE), by identifying highly preserved co-expressed genes among datasets using WGCNA. Functional annotation was then employed characterize these sets based on their relationship a whole elucidate biological processes, components, functions pathways they involved in. Lastly, drug repurposing analysis performed screen candidate repositioning could abnormal expression diseases. A total thirteen modules were obtained from analysis, majority associated with transcriptional, post-transcriptional, post-translational modification processes. Also, evaluation KEGG suggested possible role TH17 differentiation simultaneous Furthermore, clomiphene top regulating overexpressed hub genes; meanwhile, prilocaine under-expressed genes. This geared towards utilizing transcriptomics approaches assessment microarray data, different use traditional genomic analyses. Such research design investigating correlations may be first its kind.

Language: Английский

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Retinal Vascular Abnormalities and Clinical Parameters in Systemic Sclerosis

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(10), P. 2738 - 2738

Published: May 7, 2024

Background: Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. Ocular manifestations in these patients are increasingly recognized, suggesting potential correlations between systemic vascular abnormalities ocular microvascular changes. Advancements molecular immunology imaging technology using coherence tomography (OCT) have unveiled intricate pathways underlying possible pathogenesis. Understanding the interplay retinal parameters could provide insights into mechanisms biomarkers. Purpose: The aim of this study was to investigate abnormalities, detected with optical angiography (OCT-A), find severity findings OCT-A parameters. Methods: A group 32 were compared 9 healthy controls. Ganglion cell thickness (GCC), retina fovea parafovea, nerve fiber layer (RNFL) cup/disc area ratio investigated OCT. Vessel density (VD) superficial (SCP) deep capillary plexus (DCP) whole macular ETDRS grid, size foveal avascular zone (FAZ) vessel radial peripapillary (RPCP) evaluated OCT-A. Modified Rodnan skin score (mRSS), capillaroscopy duration used stage severity. Results: There statistically significant reduction VD DCP, SCP DCP grid patient controls (p < 0.001). presented enlargement FAZ 0.005). No correlation OCT scores found. Conclusions: represent non-invasive tool detect damage sclerosis.

Language: Английский

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Vascular, Soft Tissue, and Musculoskeletal Imaging in Systemic Sclerosis

Rheumatic Disease Clinics of North America, Journal Year: 2024, Volume and Issue: 50(4), P. 661 - 681

Published: Sept. 16, 2024

Language: Английский

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Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis?

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7486 - 7504

Published: July 15, 2024

Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular injury, extracellular matrix deposition, autoimmunity, inflammation, and fibrosis. The clinical complexity high heterogeneity of the disease make discovery potential therapeutic targets difficult. However, recent progress in comprehension its pathogenesis encouraging. Growth Arrest-Specific 6 (Gas6) Tyro3, Axl, MerTK (TAM) receptors are involved multiple biological processes, including modulation immune response, phagocytosis, apoptosis, fibrosis, cancer development, autoimmune disorders. In present manuscript, we review current evidence regarding SSc role Gas6/TAM system several human diseases, suggesting likely contribution highlighting areas where further research necessary to fully comprehend TAM this condition. Indeed, understanding involvement SSc, which currently unknown, could provide valuable insights for novel targets.

Language: Английский

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