EFFECTS OF MELATONIN AS ADJUVANT THERAPY IN TREATMENT OF NEONATAL SEPSIS DOI Creative Commons

Aisha Yazdani,

Bushra Adeel,

Syeda Shireen Gul

et al.

Published: Dec. 25, 2024

Background: Neonatal sepsis is a critical concern, causing significant morbidity and mortality, especially in preterm low-birth-weight infants. Traditional treatments, including antibiotics supportive care, often fall short reducing high mortality rates, emphasizing the need for effective adjunct therapies. Melatonin, known its antioxidant anti-inflammatory properties, may offer therapeutic benefits by modulating immune responses mitigating oxidative stress neonatal conditions. Objective: This study evaluates effectiveness of melatonin as an therapy sepsis, focusing on improvements clinical laboratory outcomes. Methods: In this randomized controlled trial conducted at Department Neonatology Children Hospital, PIMS, Islamabad from September 1, 2023, to February 28, 2024, 60 neonates diagnosed with were divided into two groups. The experimental group (Group A) received 20 mg enteral addition standard while control B) care alone. Key metrics such scores, C-reactive protein (CRP) levels, complete blood counts assessed baseline 48 hours post-treatment. Results: Significant observed group, scores decreasing average 12.2 ± 3.1 6.1 1.8, CRP levels 12.5 mg/ml 6.5 mg/ml, total leukocyte dropping 12,500 cells/µL 9,800 cells/µL. showed lesser across these parameters. Conclusion: Melatonin shows potential treatment effectively inflammation enhancing Further research needed substantiate findings integrate broader practices.

Language: Английский

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Luiz Gustavo de Almeida Chuffa

et al.

Life, Journal Year: 2024, Volume and Issue: 14(1), P. 88 - 88

Published: Jan. 5, 2024

Cardiovascular disease is the cause of physical infirmity and thousands deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms energy production metabolic processing. Additionally, inflammation accumulation non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces initiation progression atherosclerotic lesions, which are often basis coronary artery disease. The current review critically analyzes published data related experimental use melatonin forestall pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions reducing LDL oxidation triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, proliferation invasion arterial smooth muscle cells into lesioned area, restricting ingrowth blood vessels from vasa vasorum, solidifying plaque cap reduce chance its rupture. Diabetic hyperglycemia, aggravates also inhibited by supplementation animals. potential value non-toxic as a possible inhibitor pathology humans should be seriously considered performing clinical trials using this multifunctional molecule.

Language: Английский

Citations

10
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy DOI Creative Commons
Junyan Wang,

Xiangyi Pu,

Haowen Zhuang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. This study highlights the potential Astragaloside IV(AS) treatment septic and provides reference for developing cardioprotective drugs targeting DUSP1-PHB2-related mitochondria-ER interaction. Dual specificity phosphatase-1 (DUSP1)/Prohibitin 2 cardiomyocyte-specific knockout mice (DUSP1/PHB2CKO) /DUSP1 transgenic (DUSP1/PHB2TG) were used to generate LPS-induced sepsis models. The pathological mechanism by which AS-IV improves heart was detected using cardiac ultrasound, fluorescence staining, transmission electron microscopy, western blotting. After siRNA cardiomyocytes DUSP-1/PHB2, changes mitochondrial function morphology determined qPCR, blotting, ELISA, laser confocal targeted therapeutic effects further examined. SCM leads dysfunction. However, IV (AS) normalizes homeostasis ER function. Notably, protective effect blocked DUSP1/Prohibitin but remained unaffected DUSP1 (DUSP1/PHB2TG). AS DUSP1-PHB2 related

Language: Английский

Citations

6
Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter DOI Creative Commons

Daniel P. Cardinali,

Daniel E. Vigo

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 9, 2024

Language: Английский

Citations

4
Sepsis-induced cardiac dysfunction: mitochondria and energy metabolism DOI Creative Commons

Xueting Yu,

Jie Gao, Chunxiang Zhang

et al.

Intensive Care Medicine Experimental, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 18, 2025

Abstract Sepsis is a life-threatening multi-organ dysfunction syndrome caused by dysregulated host response to infection, posing significant global healthcare challenge. Sepsis-induced myocardial (SIMD) common complication of sepsis, significantly increasing mortality due its high energy demands and low compensatory reserves. The substantial mitochondrial damage rather than cell apoptosis in SIMD suggests disrupted cardiac metabolism as crucial pathophysiological mechanism. Therefore, we systematically reviewed the mechanisms underlying SIMD, including alterations substrates, excitation–contraction coupling processes, dysfunction, autophagy biogenesis, summarizing potential therapeutic targets within them.

Language: Английский

Citations

0
Melatonin-Mediated Protection against Sepsis-Induced Organ Dysfunction DOI
Hilal Üstündağ, Songül Doğanay

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Sepsis-induced organ dysfunction represents a critical challenge in intensive care medicine, characterized by complex pathophysiological mechanisms that can lead to multiple failure and death. This review examines the fundamental underlying sepsis-induced explores therapeutic potential of melatonin, multifaceted molecule with potent antioxidant anti-inflammatory properties. We analyzed pathways involved damage during sepsis, including inflammatory cascades, oxidative stress, mitochondrial dysfunction, endothelial injury. Special attention is given melatonin’s protective effects on various systems, cardiac, pulmonary, renal, hepatic, central nervous system function sepsis. Recent evidence suggests ability modulate these pathways, combined its excellent safety profile, makes it promising agent sepsis management. Understanding applications may provide new strategies for improving outcomes septic patients.

Language: Английский

Citations

0
Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy DOI
Eman Casper, Lamia El Wakeel, Nagwa A. Sabri

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122611 - 122611

Published: April 3, 2024

Language: Английский

Citations

3
Revealing the polarity decrease of cardiomyocyte in the septic cardiomyopathy by a lipid droplets-targeting fluorescent probe with NIR emission DOI
Xiao Zhang,

Xingyue Li,

Wenting Xu

et al.

Talanta, Journal Year: 2024, Volume and Issue: 278, P. 126452 - 126452

Published: June 22, 2024

Language: Английский

Citations

3
Bioactive extract of Morchella esculenta ameliorates cyclophosphamide-induced mitochondrial dysfunction and cardiotoxicity by modulating KEAP1/NRF2 and pro-inflammatory genes expression DOI
Sneha Das,

Thekkuttuparambil Ananthanarayanan Ajith,

K. K. Janardhanan

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 191, P. 114847 - 114847

Published: July 2, 2024

Language: Английский

Citations

2
A focus on c-Jun-N-terminal kinase signaling in sepsis-associated multiple organ dysfunction: Mechanisms and therapeutic strategies DOI

Riya Gagnani,

Mugdha Srivastava, Manisha Suri

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113552 - 113552

Published: Nov. 15, 2024

Language: Английский

Citations

2
Melatonin: A biomolecule for mitigating postharvest chilling injury in fruits and vegetables DOI Open Access
Hansika Sati, Priyanka Kataria, Ajay V. Chinchkar

et al.

Crop Science, Journal Year: 2023, Volume and Issue: 63(6), P. 3175 - 3197

Published: Oct. 14, 2023

Abstract The best strategy to extend the shelf life of fresh horticultural produce is keep it at a low temperature. However, storing fruits and vegetables temperature lower than their recommended storage above freezing point for prolonged time leads development chilling injury (CI). Melatonin (MT) being versatile biological signal has been reported possess antioxidant properties that aid in mediating stress response extending postharvest crops. Among CI‐induced mechanisms, MT substantially reduces oxidative by elevating reactive oxygen species scavenging triggering phenol accumulation association with 2, 2‐diphenyl‐1 picryl hydrazyl activity. Besides, increases intracellular energy maintaining proper ratio unsaturated saturated fatty acid improving cellular fluidity. Additionally, regulates arginine metabolism γ‐aminobutyric synthesis. Furthermore, encodes mitogen‐activated protein kinases, calcium‐dependent kinases cascade acclimate cold activating C‐repeat binding factors helps quality. This review reports recent progress MT‐induced physiological, biochemical, molecular mechanisms enhancing tolerance, which can elevate marketability earnings from

Language: Английский

Citations

6