Endometriosis and autoimmunity

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103752 - 103752

Published: Jan. 1, 2025

Language: Английский

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Induction of the Inflammasome Pathway by Tyrosine Kinase Inhibitors Provides an Actionable Therapeutic Target for Hepatocellular Carcinoma

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1491 - 1491

Published: April 13, 2024

During the last decade, tyrosine kinase inhibitors (TKIs) sorafenib and regorafenib have been standard systemic treatments for advanced hepatocellular carcinoma (HCC). Previous data associated with inflammasome activation. However, role of in signaling has not described liver cancer patients. For this purpose, we analyzed inflammasome-related transcriptomic changes a murine HCC model. Our confirmed activation after both TKI treatments, sharing similar pattern increased gene expression. According to human database results, transcriptional increase genes is poorer prognosis male patients, suggesting sex-dependent therapy. In biopsies its surrounding tissue, detected durable increases or treatment Further supporting involvement action, inhibition (MCC950) enhanced anticancer activity experimental models, while no direct vitro effect was observed cell lines. Moreover, activated THP-1 macrophages released IL-1β administration, 3D Hep3B spheres displayed tumor growth addition, pointing microenvironment as key player action. summary, our results unveil pathway an actionable target therapy associate signature tissue administration. Therefore, targeting activation, principally could help overcome resistance enhance efficacy HCC.

Language: Английский

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Recent advances in research on common targets of neurological and sex hormonal influences on asthma

Clinical and Translational Allergy, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 1, 2025

Abstract Background Asthma is currently one of the most common respiratory diseases, severely affecting lives patients. With in‐depth study role nervous system and sex hormones on development asthma, it has been found that are related to each other in pathway asthma. Objective To investigate effects Methods In this review, we searched for a large number relevant literature elucidate unique mechanisms asthma development, summarized several targets pathways Conclusion We summarize important action provide new directions ideas treatment, discuss current therapeutic limitations future possibilities. Finally, article predicts applications therapy.

Language: Английский

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Menopause triggers microglia-associated neuroinflammation in Parkinson’s disease

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149649 - 149649

Published: April 1, 2025

Language: Английский

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Effect of estradiol after bacterial infection on the Wnt/β-catenin pathway in bovine endometrium epithelial cells and organoids

Theriogenology, Journal Year: 2024, Volume and Issue: 219, P. 75 - 85

Published: Feb. 22, 2024

Language: Английский

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sAstrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 205, P. 106785 - 106785

Published: Jan. 9, 2025

Reports indicate that depression is a common mental health issue following traumatic brain injury (TBI). Our prior research suggests Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)-related neuroinflammation, modulated by glial cells such as astrocytes, likely to play crucial role in the progression of anxiety and cognitive dysfunction. However, there limited understanding potential astrocytic NLRP3 treating under mild TBI condition. This study aimed determine whether knockout (KO) could mitigate depressive-like behaviors explore variations between genders post-mild TBI. Mild was induced mice using Feeney's weight-drop method. Behavioral assessments included neurological severity scores (NSS), social interaction test (SI), tail suspension (TST), forced swimming (FST). Pathological changes were evaluated through immunofluorescence local field (LFP) recordings at various time points post-injury. findings indicated astrocyte-specific KO decreased cleaved caspase-1 colocalized with pathogenic astrocytes increased Postsynaptic density 95 (PSD95) intensity, significantly alleviated TBI-induced depression-like behaviors. It also led upregulation protective apoptosis-associated factors, including caspase-3 Additionally, deletion resulting improved θ γ power θ-γ phase coupling (SI). Notably, conditions, exhibited greater neuroprotective effects female compared males. Astrocyte demonstrated mechanism subjected TBI, possibly attributed inhibition pyroptosis signaling pathway astrocytes.

Language: Английский

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The key players of inflammasomes and pyroptosis in sepsis-induced pathogenesis and organ dysfunction

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 19, 2025

Pyroptosis is an inflammatory form of cell death involving caspase-1 or caspase-4/5/11, initiated by inflammasomes cytoplasmic endotoxins as part the immune defense. It specifically characterized Gasdermin-mediated pore formation leading to lysis, pyroptosis also entails release pro-inflammatory cytokines. As a natural mechanism system, it activates in response harmful stimuli eliminate threats and facilitate tissue repair. However, excessive can lead detrimental outcomes, such infectious shock, multiple organ dysfunction syndrome (MODS), increased susceptibility secondary infections. Sepsis, unchecked infection, remains cause MODS among critically ill patients. The pathogenesis sepsis complex multifaceted, innate inflammation that kills infected cells releases Recent research has increasingly explored link between sepsis, focusing on its mechanisms, roles, potential therapeutic targets. There been significant advancement understanding pyroptosis, highlighting vital role development sepsis. This review delves into molecular pathophysiological roles with particular emphasis impact specific organs heart, lungs, liver, kidney brain, aiming identify new diagnostic markers targets for management.

Language: Английский

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The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3866 - 3866

Published: March 30, 2024

For much of human evolution, the average lifespan was <40 years, due in part to disease, infant mortality, predators, food insecurity, and, for females, complications childbirth. Thus, many females did not reach age menopause (45–50 years age) and it is mainly past several hundred that has been extended >75 primarily public health advances, medical interventions, antibiotics, nutrition. Therefore, underlying biological mechanisms responsible disease risk following must have evolved during complex processes leading Homo sapiens serve functions pre-menopausal state. Furthermore, as a primary function survival species effective reproduction, likely most advantages having such post-menopausal risks relate reproduction ability address environmental stresses. This opinion/perspective will be discussed context how could enhance with improved offspring, perhaps why are preserved. Not all exhibit this set diseases, those who do develop diseases conditions. The state operate unified complex, but independent variables, potential some overlap. there would heterogeneity if factors essential reproductive also concept sets reversible epigenetic changes associated puberty, pregnancy, lactation offered explain observations regarding distribution conditions their roles reproduction. While involvement an system dynamic “modification-demodification-remodification” paradigm contributing hypothesis at point, validation lead better understanding commonalities may future interventions control after menopause.

Language: Английский

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Hormone and reproductive factors and risk of systemic lupus erythematosus: a Mendelian randomized study

Immunologic Research, Journal Year: 2024, Volume and Issue: 72(4), P. 665 - 674

Published: April 6, 2024

Language: Английский

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Exosome Therapy: A Novel Approach for Enhancing Estrogen Levels in Perimenopause

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7075 - 7075

Published: June 27, 2024

Perimenopause significantly impacts women's health globally, often managed with hormone replacement therapy (HRT) despite the associated risks. This study explores a novel alternative exosome therapy, aimed at stimulating estrogen production in ovarian tissues, thus offering potential non-hormonal treatment for perimenopausal symptoms. Employing ex vivo methodologies, cortex specimens from women were treated exosomes derived human umbilical cord mesenchymal stem cells and cultured under specific conditions (patent number: PCT/US2022/073467). The produced cyclic guanosine monophosphate (cGMP) conditions, ensuring high safety standards. Estrogen levels quantified using enzyme-linked immunosorbent assay (ELISA), gene expression changes follicle-stimulating (FSH) receptors assessed via quantitative polymerase chain reaction (PCR). Immunohistochemistry (IHC) was utilized to evaluate cellular proliferation apoptotic markers. results indicated significant increase receptor-alpha (Erα) tissues compared controls. Additionally, decrease markers an observed. These findings suggest that can effectively enhance modulate receptor sensitivity tissues. approach could serve as safer HRT, aligning body's natural regulatory mechanisms potentially more effective option managing

Language: Английский

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