European Journal of Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
The
aim
of
this
paper
is
enlarging
the
potential
use
ZIF‐8
MOF
as
drug
delivery
system
(DDS)
for
antimicrobial
molecules,
in
particular
sulfathiazole,
to
be
employed
treatment
Sub‐Acute
Ruminal
Acidosis
(SARA)
dairy
cows.
We
therefore
optimized
(from
milligrams
grams)
synthesis
methodology
MOF,
moving
from
organic
solvents
aqueous
solution,
deeply
characterizing
prepared
material
with
X‐ray
diffraction
(XRD),
surface
area
analyses
(BET),
electron
microscopy
(SEM),
and
thermogravimetric
(TGA).
Once
proved
that
also
reproducible,
we
tested
stability
at
physiological
acid
pH,
controlling
over
time
by
checking
their
crystallinity
XRD.
then
sulfathiazole
entrapment
method
obtain
best
material,
effective
loading
UV‐Vis
spectroscopy.
Afterwards,
checked
vs
physical
mixture
means
XRD,
SEM
ATR‐MIR
Finally
pH‐responsive
release
dialyzing
sulfathiazole@ZIF‐8
UV
spectroscopy
on
dialysis
confirming
strong
pH‐dependence
sulfathiazole.
Compounds,
Journal Year:
2025,
Volume and Issue:
5(1), P. 1 - 1
Published: Jan. 2, 2025
Metal–organic
frameworks
(MOFs)
are
also
known
as
porous
coordination
polymers.
This
kind
of
material
is
constructed
with
inorganic
nodes
(metal
ions
or
clusters)
organic
linkers
and
has
emerged
a
promising
class
materials
several
unique
properties.
Well-known
applications
MOFs
include
their
use
gas
storage
in
separation,
catalysis,
carbon
dioxide
capture,
sensing,
slender
film
gadgets,
photodynamic
therapy,
malignancy
biomarkers,
treatment,
biomedical
imaging.
Over
the
past
15
years,
an
increasing
amount
research
been
directed
to
due
advanced
fuel
cells,
supercapacitors,
catalytic
conversions,
drug
delivery
systems.
Various
synthesis
methods
have
proposed
achieve
nanometric
size
increased
surface
area,
controlled
topology,
chemical
activity
for
industrial
use.
In
this
context,
pharmaceutical
industry
watching
accelerated
development
these
great
attention.
Thus,
objective
work
study
synthesis,
characterization,
toxicity
potential
technological
excipients
carriers.
highlights
not
only
systems
(DDSs)
but
diagnostics
therapies,
such
therapy
targeted
tumors.
Bibliometric
analyses
showed
growing
interest
topic,
emphasizing
its
contemporary
relevance.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 28, 2025
This
study
explored
the
novel
mechanism
of
Astragaloside
IV
(As)
in
treating
sepsis
and
its
application
through
a
biomimetic
nano-delivery
system
(As@ZM).
Sepsis,
condition
organ
dysfunction
caused
by
an
abnormal
host
response
to
infection,
poses
significant
threat
global
health
due
high
mortality
rate.
Our
findings
revealed
new
for
As
sepsis,
which
involved
reduction
neutrophil
extracellular
traps
(NETs)
release,
potentially
related
binding
with
IκBα
inhibit
activation
NF-κB
pathway.
treated
neutrophils
also
improved
immune
microenvironment
crosstalk
endothelial
cells
lung
epithelial
cells.
However,
stability
bioavailability
limited
clinical
application.
To
address
this
issue,
we
had
developed
ZIF-8-based
that
achieved
targeted
delivery
membrane
coating,
significantly
enhancing
therapeutic
efficacy
As.
The
innovative
design
As@ZM
offered
strategy
treatment,
potential
improve
outcomes.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 24, 2025
Ovarian
cancer
(OC)
is
the
most
lethal
malignancy
in
female
reproductive
system,
and
chemotherapy
drug
resistance
main
cause
of
treatment
failure.
The
Mitogen-Activated
Protein
Kinases
(MAPK)
pathway
plays
a
pivotal
role
regulating
cell
proliferation,
migration,
invasive
capacity
response
to
extracellular
stimuli.
This
review
focuses
on
mechanisms
therapeutic
strategies
related
JNK/p38
MAPK
signaling
OC
resistance.
dual
chemoresistance.
examines
its
mediating
by
exploring
action
pathway,
particularly
involvement
several
key
biological
processes,
including
apoptosis,
autophagy,
DNA
damage
response,
tumor
microenvironment
(TME),
efflux.
Additionally,
investigates
timing
activation
this
crosstalk
with
other
pathways
such
as
PI3K/AKT
NF-κB.
Targeting
has
shown
promise
reversing
chemoresistance,
inhibitors
natural
compounds
demonstrating
potential
preclinical
studies.
Regulating
may
transform
what
was
once
terminal
obstacle
into
manageable
challenge
for
patients
resistance,
ultimately
improving
survival
quality
life.
