ZIF‐8 as Potential Vector for Enhanced Target Delivery of Sulfathiazole for the Treatment of Bovine Ruminal Acidosis DOI Creative Commons
Nicola di Nicola, Valentina Paolucci, Valeria Daniele

et al.

European Journal of Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The aim of this paper is enlarging the potential use ZIF‐8 MOF as drug delivery system (DDS) for antimicrobial molecules, in particular sulfathiazole, to be employed treatment Sub‐Acute Ruminal Acidosis (SARA) dairy cows. We therefore optimized (from milligrams grams) synthesis methodology MOF, moving from organic solvents aqueous solution, deeply characterizing prepared material with X‐ray diffraction (XRD), surface area analyses (BET), electron microscopy (SEM), and thermogravimetric (TGA). Once proved that also reproducible, we tested stability at physiological acid pH, controlling over time by checking their crystallinity XRD. then sulfathiazole entrapment method obtain best material, effective loading UV‐Vis spectroscopy. Afterwards, checked vs physical mixture means XRD, SEM ATR‐MIR Finally pH‐responsive release dialyzing sulfathiazole@ZIF‐8 UV spectroscopy on dialysis confirming strong pH‐dependence sulfathiazole.

Language: Английский

Biotin-decorated celastrol-loaded ZIF-8 nanoparticles induce ferroptosis for colorectal cancer therapy DOI Creative Commons
Jie Chen, Yan Liu, Yanting You

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 239, P. 112814 - 112814

Published: Feb. 29, 2024

Celastrol (CEL) has garnered significant interest for its anti-tumour properties and potential colorectal cancer (CRC) treatment. However, clinical use is constrained by limited bioavailability toxicity. Herein, a biotin-decorated CEL nano-drug delivery system using zeolitic imidazolate framework (ZIF-8) as carrier was synthesized, named CEL@ZIF-8@BIO. It exhibited excellent water solubility, efficient loading of CEL, high release rate in acidic environments. In vitro experiments demonstrated that CEL@ZIF-8@BIO inhibited proliferation, induced cell cycle arrest G0/G1 phase, increased ROS production reduced mitochondrial membrane CRC cells. RNA-Seq analysis indicated the anticancer mechanism may be linked to ferroptosis increase Fe2 + levels, oxidative stress, lipid peroxidation, dysfunction Furthermore, these effects could reversed inhibitor. vivo research revealed significantly growth tumours reduce toxicity associated with Taken together, shows great promise therapy due improved efficacy

Language: Английский

Citations

2
Celastrol-Loaded Hyaluronic Acid/Cancer Cell Membrane Lipid Nanoparticles for Targeted Hepatocellular Carcinoma Prevention DOI Creative Commons
Peng He,

Manshu Zou,

Chanjuan Zhang

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1819 - 1819

Published: Nov. 4, 2024

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and its prevention treatment face severe challenges. It crucial to improve targeting drugs on tumor cells tissues. Celastrol (CeT), as an active ingredient traditional Chinese medicine, possesses strong antitumor effects, especially in triggering apoptosis HCC. However, due toxicity lack targeting, application greatly limited. HMCLPs, a nano-biomimetic platform carrying CeT with controllable drug release, enhanced immunocompatibility, were developed for first time, which can be used By utilizing homologous cell membranes hyaluronic acid (HA), HMCLPs precisely target regions release controlled manner. Both vitro vivo studies have demonstrated that loaded significantly increased accumulation reactive oxygen species (ROS), induced mitochondrial damage, triggered HCC cells, resulting effective minimal adverse reaction. The development nanocarrier system delivery offers promising therapeutic strategy This innovative approach improves targeted bioavailability CeT, dramatically induces exerts powerful effects while minimizing systemic toxicity. present study highlights potential combining nanocarriers natural compounds such enhance efficacy reduce

Language: Английский

Citations

2
Druggability, molecular targets, and nanocarrier delivery of natural triterpenoid celastrol against chronic diseases DOI Creative Commons

Chi Lui Chan,

Yilu Sun,

Xiaowen Mao

et al.

Acta Materia Medica, Journal Year: 2024, Volume and Issue: 3(4)

Published: Jan. 1, 2024

Celastrol is an active compound from the root of Tripterygium wilfordii Hook F that shows great potential in treatment inflammation, cancer, neurodegeneration, diabetes, and obesity. However, clinical application celastrol has been hindered by its low bioavailability severe systemic toxicity. The aim this review was to discuss druggability, molecular targets, nanocarrier delivery natural triterpenoid, celastrol, against chronic diseases. We sequentially investigated physicochemical properties using online tools (pkCSM SwissADME), reviewed recent studies on mechanisms underlying therapeutic effects examined nanoparticle-mediated systems for safe effective celastrol. cancer-related targets pathways involved were further predicted through network pharmacologic analysis. This provides insights into activities as well useful information selection drug system various

Language: Английский

Citations

2
Thermal and self‐curing kinetics of single pack epoxy adhesive with zeolitic imidazolate framework‐8 DOI
Xiaofei Shi,

Caimian Zhang,

Wenji Zheng

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Single pack epoxy adhesives, known for their simple operation process, combined with good reactivity at moderate temperatures and excellent storage stability, have gained extensive attention. An appropriate accelerator is crucial enhancing performance. This study demonstrates that the zinc zeolitic imidazolate framework ZIF‐8 (Zn(2‐methylimidazole) 2 ) can effectively serve as an effective epoxy‐anhydride system, evidenced by complete exothermic curing curve obtained via differential scanning calorimetry (DSC) tests of (A‐128) anhydride (THPA) adhesive sample ZIF‐8. The optimal addition amount (0.9%) was determined assessing glass transition temperature ( T g cured resin varying weight fractions. Furthermore, ideal conditions—gel 388.4 K, 416.7 post‐treatment 441.9 K—were established analyzing heating curves different circumstances. system exhibited superior stability compared to commercial accelerators like PN‐23 or DMP‐30. attributed steric hindrance coordination bonds ZIF‐8, indicated a large pre‐exponential factor A 1 = 5.58 × 10 8 low‐value reaction rate constant k 0.3461 −3 s −1 ). In addition, kinetic parameters, autocatalytic equation model been derived through isothermal kinetics analysis.

Language: Английский

Citations

1
ZIF‐8 as Potential Vector for Enhanced Target Delivery of Sulfathiazole for the Treatment of Bovine Ruminal Acidosis DOI Creative Commons
Nicola di Nicola, Valentina Paolucci, Valeria Daniele

et al.

European Journal of Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract The aim of this paper is enlarging the potential use ZIF‐8 MOF as drug delivery system (DDS) for antimicrobial molecules, in particular sulfathiazole, to be employed treatment Sub‐Acute Ruminal Acidosis (SARA) dairy cows. We therefore optimized (from milligrams grams) synthesis methodology MOF, moving from organic solvents aqueous solution, deeply characterizing prepared material with X‐ray diffraction (XRD), surface area analyses (BET), electron microscopy (SEM), and thermogravimetric (TGA). Once proved that also reproducible, we tested stability at physiological acid pH, controlling over time by checking their crystallinity XRD. then sulfathiazole entrapment method obtain best material, effective loading UV‐Vis spectroscopy. Afterwards, checked vs physical mixture means XRD, SEM ATR‐MIR Finally pH‐responsive release dialyzing sulfathiazole@ZIF‐8 UV spectroscopy on dialysis confirming strong pH‐dependence sulfathiazole.

Language: Английский

Citations

0